28491-52-3

Basic information

• Product Name: 5-amino-1,2-dihydropyrazol-3-one
• Synonyms: 5-amino-1,2-dihydropyrazol-3-one;3-Amino-1,2-dihydropyrazol-5-one;3-Amino-3-pyrazolin-5-one;5-Amino-3-hydroxy-1H-pyrazole;5-AMino-1H-pyrazol-3(2H)-one;3H-Pyrazol-3-one,5-amino-1,2-dihydro-;5-Amino-1H-pyrazol-3(2H)
• CAS NO: 28491-52-3
• Molecular Formula: C₃H₅N₃O
• Molecular Weight: 99.09
• Mol File: 28491-52-3.mol

Chemical Properties

• Melting Point: 204℃
• Boiling Point: 479.5 °C at 760 mmHg
• Flash Point: 243.8 °C
• Appearance: /
• Density: 1.301
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 8.31±0.70(Predicted)
• CAS DataBase Reference: 5-amino-1,2-dihydropyrazol-3-one(CAS DataBase Reference)
• NIST Chemistry Reference: 5-amino-1,2-dihydropyrazol-3-one(28491-52-3)
• EPA Substance Registry System: 5-amino-1,2-dihydropyrazol-3-one(28491-52-3)

Safety Data

• Hazardous Substances Data: 28491-52-3(Hazardous Substances Data)

Usage

Uses

As of now, the specific applications or uses of 5-amino-1,2-dihydropyrazol-3-one are not widely discussed in scientific literature. However, given its chemical structure and the properties of similar compounds, it is possible that it could be used in various chemical synthesis processes or as an intermediate in the production of other compounds. Further research and development would be required to explore and confirm its potential applications in different industries.

Upstream product

• 140-87-4 Cyanoacetohydrazide 
• 124-41-4 sodium methylate 
• 141-52-6 sodium ethanolate 
• 39632-87-6 ethyl 3-amino-3-ethoxypropenoate 
• 37832-55-6 5-oxo-2,5-dihydro-1H-pyrazole-3-carboxylic acid 

Downstream Products

• 52565-83-0 5-amino-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid ethyl ester 
• 109652-79-1 4-phenethylidene-5-phenethylidenamino-2,4-dihydro-pyrazol-3-one 
• 28491-58-9 6-hydroxy-4-methyl-3-oxo-2,3-dihydro-pyrazolo<3,4-b>pyridine 
• 88101-46-6 7-hydroxy-5-methyl-2-oxo-1,2-dihydro-pyrazolo<1,5-a>pyrimidine 
• 103512-65-8 4,4'-bis-(4-methoxy-benzylidene)-2,2'-diphenyl-2,4,2',4'-tetrahydro-5,5'-imino-bis-pyrazol-3-one 
• 28491-67-0 4,6-dimethyl-3-oxo-2,3-dihydro-1H-pyrazolo<3,4-b>pyridine 
• 26911-66-0 2-oxo-5,7-dimethyl-1,2-dihydro-pyrazolo<1,5-a>pyrimidine 
• 861022-36-8 5-amino-2H-pyrazole-3,4-dione-4-oxime 
• 28491-63-6 6-methyl-3-oxo-2,3-dihydropyrazolo<3,4-b>pyridine 
• 28491-56-7 5-methyl-2-oxo-1,2-dihydropyrazolo<1,5-a>pyrimidine 
• 73673-38-8 6-hydroxy-4-(p-nitrophenyl)-3-oxo-2,3-dihydropyrazolo<3,4-b>pyridine 
• 2942-43-0 3-oxo-2,3-dihydropyrazolo<3,4-b>pyridine 

Relevant articles and documents

Method for preparing 5-amino-1,2-dihydropyrazole-3-one from orotic acid

The invention discloses a method for preparing 5-amino-1,2-dihydropyrazole-3-one from orotic acid, belonging to the field of drug intermediate synthesis. The method comprises the following steps: reacting orotic acid serving as a raw material with hydrazine hydrate to generate 5-oxygen-2,5-dihydropyrazole-3-carboxylic acid; reacting 5-oxygen-2,5-dihydropyrazole-3-carboxylic acid with diphenylphosphoryl azide by taking triethylamine as alkali to cause Curtis rearrangement, and carrying out hydrolysis, so as to generate 5-amino-1,2-dihydropyrazole-3-one. According the method, the cheap and easily available natural substances are taken as the raw materials, no strong base is utilized, and by-products are safe; meanwhile, the process selection is reasonable, the facility requirement is low, the operation is simple, the yield is high, the total yield can reach 83%, and the production is easily enlarged; the method is applicable to the large-scale production of 5-amino-1,2-dihydropyrazole-3-one.