- Antimicrobial Evaluation of New Quinoxaline Derivatives Synthesized by Selective Coupling with Alkyl Halides and Amino Acids Esters
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Alkylation of quinoxaline scaffold 1 in the presence of K2CO3 preferred N-alkylation than O-alkylation. Quinoxaline hydrazide 6 was successfully coupled with various amino acids, esters, and amines via azide-coupling method. New heterocyclic compounds containing quinoxaline linked to 1,3,4-oxadiazolethione or pyrazole were obtained from cyclization of 6 with CS2 and acetylacetone, respectively. A series of hydrazide Schiff's bases were formed from hydrazide 6 by condensation with a set of aldehydes and ketones. NMR spectroscopy and mass spectrometry were used for structure elucidation of new compounds. The antimicrobial activity of the synthesized compounds was investigated toward two wild-type bacterial strains (Staphylococcus aureus and Escherichia coli) and two fungal species (Alternaria brassicicola and Fusarium oxysporum). Four compounds displayed a significant activity toward S.?aureus. The ester 4 showed higher activity than the standard drugs, which make it a promising lead compound.
- Boraei, Ahmed T. A.,El Tamany, El Sayed H.,Ali, Ibrahim A. I.,Gebriel, Sara M.
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p. 2881 - 2888
(2017/09/26)
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- Investigation of the reaction of N-acetylindoxyl with substituted anilines. Synthesis of derivatives of indolo[3,2-b]quinolines
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1-Acetyl-2,3-dihydrospiro[indolo-3, 2′-(1′,2′,3′, 4′-tetrahydroquinazolin-4′-one) was obtained from the reaction with anthranilamide, and 3-(2′-acetylaminophenyl)quinoxalin-2-one from the reaction with o-phenylenediamine, along with the normal products of the condensation of N-acetylindoxyl with substituted anilines. Derivatives of indolo[3,2-b]quinoline were synthesized from the obtained condensation products.
- Tugusheva,Ryabova,Solov'eva,Anisimova,Granik
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p. 885 - 893
(2007/10/03)
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- REACTION OF o-PHENYLENEDIAMINE WITH ISATINS
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It is shown that the reaction of o-phenylenediamine with isatins in the general case leads to mixtures of indoloquinoxalines, 3-(2'-aminophenyl)-2(1H)-quinoxalinones, and spiro.Spiro2H-benzimidazole-2,3'-in
- Ivashchenko, A. V.,Drushlyak, A. G.,Titov, V. V.
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p. 537 - 542
(2007/10/02)
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- Reaction of N-Acylisatins with Diamines
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The reaction of N-acylisatins with aromatic and heterocyclic 1,2-diamines results in opening of the N-C2 bond and leads to the 2-o-acetamidophenylquinoxaline derivatives (6) and (7).With ethylenediamine and 1,3-diaminopropane, compounds (9a) and (9b) resp
- Joshi, B. S.,Likhate, M. A.,Viswanathan, N.
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p. 114 - 116
(2007/10/02)
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