919101-04-5Relevant articles and documents
Amphoteric amino aldehydes enable rapid assembly of unprotected amino alcohols
Hili, Ryan,Yudin, Andrei K.
supporting information; experimental part, p. 4188 - 4191 (2009/03/11)
(Chemical Equation Presented) Apples and oranges: The term "amphoteric" is derived from the Greek "amphoteros", which literally means "both of two". Amphoteric amino aldehydes are counterintuitive molecules in that they contain both electrophilic and nucl
AZIRIDINE ALDEHYDES, AZIRIDINE-CONJUGATED AMMO DERIVATIVES, AZIRIDINE-CONJUGATED BIOMOLECULES AND PROCESSES FOR THEIR PREPARATION
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Page/Page column 69; 70, (2008/12/05)
The present invention relates to unprotected amino aldehydes and applications for same. More particularly, the present invention relates to novel aziridine aldehydes and processes for preparing these novel compounds. The invention also relates to aziridine-conjugated amino derivatives, and processes for preparing the same. Pentacyclic compounds may be prepared using the aziridine aldehydes of the present invention, and the invention relates to these compounds and the processes by which they are made. The invention also relates to aziridine-conjugated bioactive molecules, such as amino acids and peptides, and processes for preparing such compounds.
Readily available unprotected amino aldehydes
Hili, Ryan,Yudin, Andrei K.
, p. 14772 - 14773 (2008/02/05)
We report a new class of bench-stable compounds that contain seemingly incompatible functional groups: an aldehyde and an unprotected secondary amine. The thermodynamic driving force to undergo condensation between these two functionalities is offset by a