925434-55-5

Basic information

• Product Name: N-[2-[3-(1-Piperazinylmethyl)imidazo[2,1-b]thiazol-6-yl]phenyl]-2-quinoxalinecarboxamide
• Synonyms: N-[2-[3-(1-Piperazinylmethyl)imidazo[2,1-b]thiazol-6-yl]phenyl]-2-quinoxalinecarboxamide;N-(2-(3-(piperazin-1-ylmethyl)imidazo[2,1-b]thiazol-6-yl)phenyl)quinoxaline-2-carboxamide;2-QuinoxalinecarboxaMide, N-[2-[3-(1-piperazinylMethyl)iMidazo[2,1-b]thiazol-6-yl]phenyl]-;SRT1720 free base/ STR1720 HCl salt;Quinoxaline-2-carboxylic acid [2-(3-piperazin-1-ylmethyl-imidazo[2,1-b]thiazol-6-yl)-phenyl]-amide
• CAS NO: 925434-55-5
• Molecular Formula: C25H23N7OS
• Molecular Weight: 469.571
• Mol File: 925434-55-5.mol

Chemical Properties

• Melting Point: 221℃
• Appearance: /
• Density: 1.46
• Storage Temp.: -20C
• PKA: 11.19±0.70(Predicted)
• CAS DataBase Reference: N-[2-[3-(1-Piperazinylmethyl)imidazo[2,1-b]thiazol-6-yl]phenyl]-2-quinoxalinecarboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-[2-[3-(1-Piperazinylmethyl)imidazo[2,1-b]thiazol-6-yl]phenyl]-2-quinoxalinecarboxamide(925434-55-5)
• EPA Substance Registry System: N-[2-[3-(1-Piperazinylmethyl)imidazo[2,1-b]thiazol-6-yl]phenyl]-2-quinoxalinecarboxamide(925434-55-5)

Safety Data

• Hazardous Substances Data: 925434-55-5(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
N-[2-[3-(1-Piperazinylmethyl)imidazo[2,1-b]thiazol-6-yl]phenyl]-2-quinoxalinecarboxamide is used as a potential therapeutic agent for type 2 diabetes due to its ability to offer therapeutic benefits in several murine and rodent models.
Used in Research Applications:
N-[2-[3-(1-Piperazinylmethyl)imidazo[2,1-b]thiazol-6-yl]phenyl]-2-quinoxalinecarboxamide is used as a research tool to study the role of SIRT3 in cellular processes, as well as its effects on p53 Lys382 acetylation and p300 HAT activity.

Upstream product

• 6851-99-6 2-bromo-1-(2-nitrophenyl)ethanone 
• 1093403-37-2 C₁₃H₁₁N₃O₅S₂ 
• 912770-13-9 6-(2-nitro-phenyl)-imidazo[2,1-b]thiazole-3-carboxylic acid 
• 925437-84-9 6-(2-nitrophenyl)-imidazo[2,1-b]thiazole-3-carboxylic acid ethyl ester 
• 925437-85-0 (6-(2-nitrophenyl)imidazo[2,1-b]thiazol-3-yl)methanol 
• 54745-92-5 quinoxaline-2-carboxylic acid chloride 
• 925437-87-2 4-[6-(2-aminophenyl)imidazo[2,1-b]thiazol-3-ylmethyl]piperazine-1-carboxylic acid tert-butyl ester 
• 1093403-41-8 C₂HF₃O₂*C₂₅H₂₃N₇OS 
• 925436-46-0 C₃₀H₃₁N₇O₃S 

Relevant articles and documents

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A series of imidazo[1,2-b]thiazole derivatives is shown to activate the NAD+-dependent deacetylase SIRT1, a potential new therapeutic target to treat various metabolic disorders. This series of compounds was derived from a high throughput scree

SIRTUIN MODULATING IMIDAZOTHIAZOLE COMPOUNDS

Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.