(αMe)Hyv: Chemo-enzymatic synthesis, and preparation and preferred conformation of model depsipeptides
By a chemo-enzymatic approach we performed a large-scale, stereoselective synthesis of the Cα-methylated α-hydroxy acid L-(αMe)Hyv. We also prepared model depsipeptides based on this sterically demanding residue in combination with the α-amino
Two asymmetric syntheses of AMG 221, an inhibitor of 11β- hydroxysteroid dehydrogenase type 1
(Chemical Equation Presented) Two asymmetric syntheses of AMG 221 (2), an inhibitor of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) discovered in our laboratories, are reported. One of the syntheses utilizes chiral trimethylsilyl cyanohydrin 12 as s
Caille, Seb,Cui, Sheng,Hwang, Tsang-Lin,Wang, Xiang,Faul, Margaret M.
experimental part
p. 3833 - 3842
(2009/11/30)
Enzyme-catalyzed synthesis of (R)-ketone-cyanohydrins and their hydrolysis to (R)-α-hydroxy-α-methyl-carboxylic acids
(R)-Ketone-cyanohydrins (R)-2 are obtained with high enantioselectivity from aliphatic ketones 1 and HCN in organic solvents using (R)-oxynitrilase ( EC 4.1.2.10) as catalyst. Acid catalyzed hydrolysis of the cyanohydrins (R)-2 affords the corresponding (R)-α-hydroxy-α-methyl-carboxylic acids (R)-3 without measurable racemization.
Effenberger,Horsch,Weingart,Ziegler,Kuhner
p. 2605 - 2608
(2007/10/02)
More Articles about upstream products of 92735-50-7