- Direct transformation from arylamines to aryl naphthalene-1,8-diamino boronamides: A metal-free sandmeyer-type process
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A direct metal-free transformation from arylamines to aryl naphthalene-1,8-diamino boronamides, a type of masked boronic acid, has been developed based on Sandmeyer-type reactions. A nonsymmetrical diboron reagent, B(pin)-B(dan), was utilized as the boryl
- Ding, Siyi,Ma, Qiang,Zhu, Min,Ren, Huaping,Tian, Shaopeng,Zhao, Yuzhen,Miao, Zongcheng
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- IMIDAZOPYRIDAZINE DERIVATIVES AS MODULATORS OF THE GABAA RECEPTOR ACTIVITY.
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The present invention relates to imidazopyridazine derivatives. More particularly, it relates to 4-(biphenyl-3-yl)-7H-imidazo[4,5-c]pyridazine derivatives of formula (I) and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R and R6 are as defined in the description. The imidazopyridazine derivatives of the present invention modulate the activity of the GABAA receptor. They are useful in the treatment of a number of conditions, including pain.
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Page/Page column 72
(2016/01/01)
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- Chemical Compounds
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The present invention relates to imidazopyridazine derivatives. More particularly, it relates to 4-(biphenyl-3-yl)-7H-imidazo[4,5-c]pyridazine derivatives of formula (I): and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4 and R5 are as defined in the description. The imidazopyridazine derivatives of the present invention modulate the activity of the GABAA receptor. They are useful in the treatment of a number of conditions, including pain.
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Paragraph 0626; 0627
(2014/06/25)
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- Boron-masking strategy for the selective synthesis of oligoarenes via iterative Suzuki-Miyaura coupling
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The iterative synthesis of oligoarenes via an organoborane-based cross-coupling reaction (i.e., the Suzuki-Miyaura coupling) has been achieved by using a series of "masked" haloarylboronic acids as building blocks whose ordinarily reactive boronyl groups are temporarily protected by a new masking group derived from 1,8-diaminonaphthalene. Copyright
- Noguchi, Hiroyoshi,Hojo, Kosho,Suginome, Michinori
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p. 758 - 759
(2007/10/03)
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