928-70-1

Basic information

• Product Name: POTASSIUM ISOAMYLXANTHATE
• Synonyms: carbonicacid,dithio-,o-isopentylester,potassiumsalt;Carbonodithioicacid,O-(3-methylbutyl)ester,potassiumsalt;potassiumisopentylxanthate;potassiumisopentylxanthogenate;potassiumo-isoamylxanthate;POTASSIUM ISOAMYLXANTHATE;potassium isopentyl dithiocarbonate;Potassium O-(2-methylbutyl) dithiocarbonate
• CAS NO: 928-70-1
• Molecular Formula: C₆H₁₁OS₂*K
• Molecular Weight: 202.38
• EINECS: 213-180-2
• Product Categories: Beneficiation Reagent
• Mol File: 928-70-1.mol

Chemical Properties

• Boiling Point: 553.11°C (rough estimate)
• Flash Point: 65.3°C
• Appearance: /
• Density: 1.2513 (rough estimate)
• Vapor Pressure: 1.01mmHg at 25°C
• Refractive Index: 1.6000 (estimate)
• PKA: 1.51[at 20 ℃]
• Water Solubility: 350g/L at 20℃
• CAS DataBase Reference: POTASSIUM ISOAMYLXANTHATE(CAS DataBase Reference)
• NIST Chemistry Reference: POTASSIUM ISOAMYLXANTHATE(928-70-1)
• EPA Substance Registry System: POTASSIUM ISOAMYLXANTHATE(928-70-1)

Safety Data

• Hazardous Substances Data: 928-70-1(Hazardous Substances Data)

Usage

Flammability and Explosibility

Highlyflammable

InChI:InChI=1/C6H12OS2/c1-5(2)3-4-7-6(8)9/h5H,3-4H2,1-2H3,(H,8,9)

Upstream product

• 75-15-0 carbon disulfide 
• 123-51-3 i-Amyl alcohol 

Downstream Products

• 93097-84-8 di-O-isoamyl-S,S-phthaloyl dixanthate (symmetrical) 
• 1861-54-7 O-(3-Methyl-butyl)-S-(4-brom-phenacyl)-dithiocarbonat 
• 1861-74-1 O-(3-Metyl-butyl)-S-(4-chlor-phenacyl)-dithiocarbonat 
• 75-15-0 carbon disulfide 
• 123-51-3 i-Amyl alcohol 

Relevant articles and documents

Versatile coordination environment and interplay of metal assisted secondary interactions in the organization of supramolecular motifs in new Hg(II)/PhHg(II) dithiolates

New mercury(II) complexes of the form [PhHg(L)] (L = L1 (1), L2 (2), L3′ (3), L4 = (4)); [Hg(L)2] (L = L5 (5), L4 (7) and [Hg 2(L6)4] (6) have been synthesized and characterized by micro analysis and X-ray crystallography. Both 1 and 2 are linear; complex 2 revealed intramolecular Hga?O bonding interactions. Complex 3 possesses T-shaped geometry in a linear polymeric chain motif. Although serendipitously formed, 3 is the first example of a metal trithioxanthate complex. 4 is a typical dimer and in 5, a helical chain motif is generated via Hga?S contacts. 6 is a dinuclear complex with distorted square pyramidal geometry. 7 is mononuclear with a tetrahedrally coordinated mercury(II) ion. All complexes are luminescent in solution and solid state. In 2 the nature of Hga?O interactions have been assessed by DFT calculations and the electronic transitions in 3 have been corroborated by TDDFT calculations.

Xanthates and trithiocarbonates strongly inhibit carbonic anhydrases and show antiglaucoma effects in vivo

Dithiocarbamates (DTCs) were recently discovered as carbonic anhydrase (CA, EC 4.2.1.1) inhibitors. A series of xanthates and a trithiocarbonate, structurally related to the DTCs, were prepared by reaction of alcohols/thiols with carbon disulfide in the presence of bases. These compounds were tested for the inhibition of four human (h) isoforms, hCA I, II, IX, and XII, involved in pathologies such as glaucoma (CA II and XII) or cancer (CA IX). Several low nanomolar xanthate/trithiocarbonate inhibitors targeting these CAs were detected. A docking study of some xanthates within the CA II active site showed that these compounds bind in a similar manner with the dithiocarbamates, coordinating monodentately to the Zn(II) ion from the enzyme active site. Several xanthates showed potent intraocular pressure lowering activity in two animal models of glaucoma via the topical administration. Xanthates and thioxanthates represent two novel, promising classes of CA inhibitors.