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2-(3-Chloropropoxy)-1-methoxy-4-nitrobenzene is an organic compound characterized by its chemical formula C10H12ClNO4. It features a benzene ring with a nitro and methoxy group at the para position, and a chloropropoxy group at the ortho position. 2-(3-Chloropropoxy)-1-methoxy-4-nitrobenzene is recognized for its role as an intermediate in the synthesis of various drugs and pesticides, predominantly in the pharmaceutical and agrochemical industries.

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  • 92878-95-0 Structure
  • Basic information

    1. Product Name: 2-(3-CHLOROPROPOXY)-1-METHOXY-4-NITROBENZENE
    2. Synonyms: 2-(3-CHLOROPROPOXY)-1-METHOXY-4-NITROBENZENE
    3. CAS NO:92878-95-0
    4. Molecular Formula: C10H12ClNO4
    5. Molecular Weight: 245.66
    6. EINECS: 1312995-182-4
    7. Product Categories: N/A
    8. Mol File: 92878-95-0.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 388.3 °C at 760 mmHg
    3. Flash Point: 188.6 °C
    4. Appearance: /
    5. Density: 1.268 g/cm3
    6. Refractive Index: N/A
    7. Storage Temp.: 2-8°C
    8. Solubility: N/A
    9. CAS DataBase Reference: 2-(3-CHLOROPROPOXY)-1-METHOXY-4-NITROBENZENE(CAS DataBase Reference)
    10. NIST Chemistry Reference: 2-(3-CHLOROPROPOXY)-1-METHOXY-4-NITROBENZENE(92878-95-0)
    11. EPA Substance Registry System: 2-(3-CHLOROPROPOXY)-1-METHOXY-4-NITROBENZENE(92878-95-0)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 92878-95-0(Hazardous Substances Data)

92878-95-0 Usage

Uses

Used in Pharmaceutical Industry:
2-(3-Chloropropoxy)-1-methoxy-4-nitrobenzene is used as a chemical intermediate for the synthesis of pharmaceuticals. It plays a crucial role in the development of new drugs, contributing to the advancement of medicinal chemistry.
Used in Agrochemical Industry:
In the agrochemical sector, 2-(3-Chloropropoxy)-1-methoxy-4-nitrobenzene is utilized as an intermediate in the production of pesticides. Its involvement in the synthesis process helps in creating effective pest control solutions for agricultural applications.
Given its potential hazards, 2-(3-Chloropropoxy)-1-methoxy-4-nitrobenzene should be handled with care due to its toxic nature, which may pose risks to human health and the environment.

Check Digit Verification of cas no

The CAS Registry Mumber 92878-95-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,2,8,7 and 8 respectively; the second part has 2 digits, 9 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 92878-95:
(7*9)+(6*2)+(5*8)+(4*7)+(3*8)+(2*9)+(1*5)=190
190 % 10 = 0
So 92878-95-0 is a valid CAS Registry Number.

92878-95-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-(3-Chloropropoxy)-1-methoxy-4-nitrobenzene

1.2 Other means of identification

Product number -
Other names 2-(3-CHLOROPROPOXY)-1-METHOXY-4-NITROBENZENE

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:92878-95-0 SDS

92878-95-0Relevant articles and documents

Method for preparing bosutinib intermediate

-

Paragraph 0079-0080, (2020/09/20)

The invention provides a method for preparing a bosutinib intermediate. The method comprises the following steps: A, adding SM-1, 1-bromo-3-chloropropane and an acid-binding agent into a reaction solvent, controlling the temperature until the reaction is

HISTONE METHYLTRANSFERASE INHIBITORS

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Page/Page column 106, (2018/07/29)

The present disclosure provides certain angular tricyclic compounds that are histone methyltransi erases G9a and/or GLP inhibitors and are therefore useful for the treatment of diseases treatable by inhibition of G9a and/or GLP such as cancers and hemoglobinpathies (e.g., beta- thalassemia and sickle cell disease). Also provided are pharmaceutical compositions containing such compounds and processes for preparing such compounds.

Identification of highly potent BTK and JAK3 dual inhibitors with improved activity for the treatment of B-cell lymphoma

Ge, Yang,Wang, Changyuan,Song, Shijie,Huang, Jiaxin,Liu, Zhihao,Li, Yongming,Meng, Qiang,Zhang, Jianbin,Yao, Jihong,Liu, Kexin,Ma, Xiaodong,Sun, Xiuli

, p. 1847 - 1857 (2017/12/04)

The BTK and JAK3 receptor tyrosine kinases are two validated and therapeutically amenable targets in the treatment of B-cell lymphomas. Here we report the identification of several classes of pyrimidine derivatives as potent BTK and JAK3 dual inhibitors.

PYRIMIDINE-2,4-DIAMINE DERIVATIVES AND THEIR USE AS JAK2 KINASE INHIBITORS

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Page/Page column 19, (2008/12/08)

Pyrimidine-2,4-diamines derivatives having activity as JAK2 kinase inhibitors are disclosed, as well as pharmaceutical compositions and methods for using the same in the treatment of cancer and other JAK2 kinase-associated conditions.

Process for preparation of 4-amino-3-quinolinecarbonitriles

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Page/Page column 7, (2010/02/10)

This invention discloses a process for the preparation of a 4-amino-3-quinolinecarbonitrile comprising combining an amine compound with a cyanoacetic acid and an acid catalyst to yield a cyanoacetamide; condensing the cyanoacetamide with an optionally up to tetra-substituted aniline in an alcoholic solvent and a trialkylorthoformate to yield a 3-amino-2-cyanoacrylamide; combining the 3-amino-2-cyanoacrylamide with phosphorus oxychloride in acetonitrile, butyronitrile, toluene or xylene, optionally in the presence of a catalyst to yield a 4-amino-3-quinolinecarbonitrile and also discloses a process for the preparation of a 7-amino-thieno[3,2-b]pyridine-6-carbonitrile comprising combining a disubstituted 3-amino thiophene with a cyanoacetamide and trialkylorthoformate in an alcoholic solvent to obtain a 3-amino-2-cyanoacrylamide; and combining the 3-amino-2-cyanoacrylamide with phosphorus oxychloride and acetonitrile, butyronitrile, toluene or xylene, optionally in the presence of a catalyst to yield a 7-amino-thieno[3,2-b]pyridine-6-carbonitrile and also discloses a process for the preparation of a 4-amino-3-quinolinecarbonitrile by combining an amine compound with a cyanoacetic acid and a peptide coupling reagent to obtain a suspension; filtering the suspension to yield a cyanoacetamide; condensing the cyanoacetamide with an optionally up to tetra-substituted aniline, an alcoholic solvent, and triethylorthoformate to yield a 3-amino-2-cyanoacrylamide; and combining the 3-amino-2-cyanoacrylamide with phosphorus oxychloride to yield a 4-amino-3-quinolinecarbonitrile.

PHOTOINDUCED INTRAMOLECULAR SUBSTITUTION-III PHOTOCYCLIZATION OF ω-ANILINOALKYL m-NITROPHENYL ETHERS

Mutai, Kiyoshi,Kobayashi, Keiji,Yokoyama, Kenji

, p. 1755 - 1760 (2007/10/02)

Irradiation of 1-(m-nitrophenoxy)-ω-anilinoalkanes, m-O2NC6H4O(CH2)nNHPh (n = 2 and 3) and their 1-(2-methoxy-5-nitrophenoxy) analogs induced intramolecular cyclization in which a hydrogen or methoxyl

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