846023-54-9

Usage

Uses

Used in Pharmaceutical Research:
1-[3-(2-Methoxy-5-nitrophenoxy)propyl]-4-Methylpiperazine is used as a ligand in pharmaceutical research for the study of serotonin receptors. Its structural similarity to serotonin allows it to interact with these receptors, providing insights into their function and the development of new drugs targeting them.
Used in the Treatment of Central Nervous System Disorders:
In the medical field, 1-[3-(2-Methoxy-5-nitrophenoxy)propyl]-4-Methylpiperazine is considered for its potential therapeutic applications in treating a range of central nervous system disorders. Its interaction with serotonin receptors suggests it may be effective in managing conditions such as depression, anxiety, and psychosis.
Used in Drug Discovery:
1-[3-(2-Methoxy-5-nitrophenoxy)propyl]-4-Methylpiperazine's structure and functional properties position it as a valuable tool in drug discovery. Researchers utilize 1-[3-(2-Methoxy-5-nitrophenoxy)propyl]-4-Methylpiperazine to identify new leads and develop novel medications aimed at addressing mental health conditions, potentially leading to more effective treatments with fewer side effects.
Used in the Development of New Medications for Mental Health Conditions:
Given its potential pharmacological applications, 1-[3-(2-Methoxy-5-nitrophenoxy)propyl]-4-Methylpiperazine is employed in the development of new medications specifically for mental health conditions. Its role in modulating serotonin receptor activity could lead to advancements in treating disorders where serotonin dysregulation is implicated.

InChI:InChI=1/C15H23N3O4/c1-16-7-9-17(10-8-16)6-3-11-22-15-12-13(18(19)20)4-5-14(15)21-2/h4-5,12H,3,6-11H2,1-2H3

Upstream product

• 636-93-1 5-nitroguaiacol 
• 109-01-3 1-methyl-piperazine 
• 92878-95-0 1-(2-methoxy-5-nitrophenoxy)-3-chloropropane 

Downstream Products

• 846023-56-1 2-cyano-N-(2,4-dichloro-5-methoxyphenyl)-3-{4-methoxy-3-[3-(4-methylpiperazin-1-yl)-propoxy]-phenylamino}-acrylamide 
• 380843-75-4 bosutinib 
• 846023-55-0 4-methoxy-3-[3-(4-methylpiperazin-1-yl)propoxy]phenylamine 

Relevant academic research and scientific papers

Method for preparing bosutinib intermediate

The invention provides a method for preparing a bosutinib intermediate. The method comprises the following steps: A, adding SM-1, 1-bromo-3-chloropropane and an acid-binding agent into a reaction solvent, controlling the temperature until the reaction is

A robust, streamlined approach to bosutinib monohydrate

This article describes a systematic approach used to streamline the process for the isolation of bosutinib monohydrate, a promiscuous solvate former. A thorough understanding of the complex solid form landscape was garnered, and this knowledge was used to

PYRIMIDINE-2,4-DIAMINE DERIVATIVES AND THEIR USE AS JAK2 KINASE INHIBITORS

Pyrimidine-2,4-diamines derivatives having activity as JAK2 kinase inhibitors are disclosed, as well as pharmaceutical compositions and methods for using the same in the treatment of cancer and other JAK2 kinase-associated conditions.

Process for preparation of 4-amino-3-quinolinecarbonitriles

This invention discloses a process for the preparation of a 4-amino-3-quinolinecarbonitrile comprising combining an amine compound with a cyanoacetic acid and an acid catalyst to yield a cyanoacetamide; condensing the cyanoacetamide with an optionally up to tetra-substituted aniline in an alcoholic solvent and a trialkylorthoformate to yield a 3-amino-2-cyanoacrylamide; combining the 3-amino-2-cyanoacrylamide with phosphorus oxychloride in acetonitrile, butyronitrile, toluene or xylene, optionally in the presence of a catalyst to yield a 4-amino-3-quinolinecarbonitrile and also discloses a process for the preparation of a 7-amino-thieno[3,2-b]pyridine-6-carbonitrile comprising combining a disubstituted 3-amino thiophene with a cyanoacetamide and trialkylorthoformate in an alcoholic solvent to obtain a 3-amino-2-cyanoacrylamide; and combining the 3-amino-2-cyanoacrylamide with phosphorus oxychloride and acetonitrile, butyronitrile, toluene or xylene, optionally in the presence of a catalyst to yield a 7-amino-thieno[3,2-b]pyridine-6-carbonitrile and also discloses a process for the preparation of a 4-amino-3-quinolinecarbonitrile by combining an amine compound with a cyanoacetic acid and a peptide coupling reagent to obtain a suspension; filtering the suspension to yield a cyanoacetamide; condensing the cyanoacetamide with an optionally up to tetra-substituted aniline, an alcoholic solvent, and triethylorthoformate to yield a 3-amino-2-cyanoacrylamide; and combining the 3-amino-2-cyanoacrylamide with phosphorus oxychloride to yield a 4-amino-3-quinolinecarbonitrile.