92943-93-6Relevant articles and documents
PROCEDURE FOR OBTAINING GADOTERATE MEGLUMINE FROM HIGH-PURITY TETRAXETAN (DOTA) AND ITS USE IN THE PREPARATION OF INJECTABLE GALENICAL FORMULATIONS
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Page/Page column 10, (2021/12/31)
The present invention refers to a process for obtaining gadoterate meglumine from high purity tetraxetan (DOTA) which does not require the use of organic solvents and optimizes the conditions of the synthetic process. The tetraxetan from which the gadoterate meglumine is obtained by a synthetic process that includes a purification step in which at least one electrodialysis is performed. This procedure makes it possible to obtain a tetraxetan and a gadoterate meglumine with minimal amounts of impurities.