6284-40-8 Usage
Description
Meglumine, also known as N-Methyl-D-glucamine, is an organic compound derived from the natural sugar glucose. It is a quaternary ammonium compound with amine and hydroxyl groups, which gives it unique properties and makes it suitable for various applications across different industries.
Uses
Used in Pharmaceutical Industry:
Meglumine is used as an excipient in pharmaceuticals for its ability to improve the solubility and stability of certain drugs. It enhances the bioavailability and effectiveness of medications, making it a valuable component in drug formulations.
Used in Cosmetics Industry:
In the cosmetics industry, Meglumine is used as an excipient for its emulsifying and stabilizing properties. It helps to create a uniform texture and maintain the stability of cosmetic products, ensuring their quality and performance.
Used in X-ray Contrast Media:
Meglumine is used as an excipient in X-ray contrast media, such as diatrizoate meglumine and iodipamide meglumine. It helps to improve the solubility and distribution of iodinated organic compounds, which are essential for enhancing the visibility of internal structures during X-ray imaging.
Used in Ion-exchange Resins:
Meglumine is employed in ion-exchange resins to selectively chelate boron ions. This application is crucial in various industrial processes, including water treatment and nuclear power plant operations, where the removal or control of specific ions is necessary.
Used in Synthesis of Surface Active Agents, Pharmaceuticals, and Dyes:
Meglumine is also utilized in the synthesis of various compounds, such as surface-active agents, pharmaceuticals, and dyes. Its unique chemical properties make it a versatile building block for the development of new and improved products in these industries.
Used in Anti-inflammatory Applications:
Meglumine has anti-inflammatory properties, which can be beneficial in the treatment of various inflammatory conditions. Its ability to reduce inflammation and alleviate pain makes it a valuable component in pharmaceutical formulations for managing inflammation-related disorders.
Production Methods
Meglumine is prepared by the imination of glucose and monomethylamine,
in an alcoholic solution, followed by catalytic
hydrogenation.
Pharmaceutical Applications
Meglumine is an organic base used as a pH-adjusting agent and
solubilizing agent, primarily in the preparation of soluble salts of
iodinated organic acids used as X-ray contrast media.
Safety
Meglumine is widely used in parenteral pharmaceutical formulations
and is generally regarded as a nontoxic material at the levels
usually employed as an excipient.
LD50 (mouse, IP): 1.68 g/kg
storage
Meglumine does not polymerize or dehydrate unless heated above
150°C for prolonged periods.
The bulk material should be stored in a well-closed container in a
cool, dry place. Meglumine should not be stored in aluminum
containers since it reacts to evolve hydrogen gas; it discolors if
stored in containers made from copper or copper alloys. Stainless
steel containers are recommended.
Purification Methods
Crystallise N-methyl-D(-)-glucamine from MeOH. Its solubility in H2O is 10%. [Karrer & Herkenrath Helv Chim Acta 20 83 1957 also for other N-alkyl derivatives, Beilstein 4 IV 1914.]
Incompatibilities
Incompatible with aluminum, copper, mineral acids, and oxidizing
materials. Differential scanning calorimetry studies suggest meglumine
is incompatible with glipizide.
Regulatory Status
Included in the FDA Inactive Ingredients Database (injections; oral
tablets). Included in parenteral medicines licensed in the UK.
Check Digit Verification of cas no
The CAS Registry Mumber 6284-40-8 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,2,8 and 4 respectively; the second part has 2 digits, 4 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 6284-40:
(6*6)+(5*2)+(4*8)+(3*4)+(2*4)+(1*0)=98
98 % 10 = 8
So 6284-40-8 is a valid CAS Registry Number.
InChI:InChI=1/C7H17NO5/c1-8-2-4(10)6(12)7(13)5(11)3-9/h4-13H,2-3H2,1H3/p+1/t4-,5-,6+,7-/m1/s1
6284-40-8Relevant articles and documents
Method for synthesizing meglumine through catalytic hydrogenation by taking ammonia borane as hydrogen source
-
Paragraph 0020-0022; 0025, (2018/10/19)
The invention discloses a method for synthesizing meglumine through catalytic hydrogenation by taking ammonia borane as a hydrogen source, and belongs to the technical field of chemical drug synthesis. The method comprises the step that on the basis that glucose-methylamine schiff base is synthesized by taking glucose and methylamine as raw materials, and by taking ammonia borane as the hydrogen source for performing catalytic hydrogenation, the meglumine is synthesized. Compared with a method in the past, the method has the advantages of being mild in catalytic hydrogenation reaction, safe and high yield.
Mixed Sugar Compositions
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Paragraph 0207, (2014/09/29)
Novel mixtures of sugar amides or sugar amines are disclosed that have improved thermal properties over the individual components. New feedstocks based on both the surfactant tail as well as the sugar head group allow for improved physical properties of sugar amide surfactant mixtures and thus improved formulatability. Furthermore, new sources of unique methyl esters from both bioengineering and or co-metathesis of fats and oils provide novel and improved sugar amide surfactant mixtures.
Composition and Tablet Comprising Raltegravir
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, (2012/12/14)
The present invention relates to a composition and tablet comprising raltegravir and to a process for the preparation of such tablet.