93-67-4

Basic information

• Product Name: 5-Chloro-2-phenoxyaniline
• Synonyms: 2-AMINO-4-CHLOROPHENYL PHENYL ETHER;TIMTEC-BB SBB003358;5-chloro-2-phenoxybenzenamine;4-Chlor-2-aminodiphenylether;5-chloro-2-phenoxyphenylamine;Azoic DC 26(base);C.I.37070(base);C.I.Azoic Diazo Component 26(base)
• CAS NO: 93-67-4
• Molecular Formula: C₁₂H₁₀ClNO
• Molecular Weight: 219.67
• EINECS: 202-266-5
• Product Categories: Biphenyl & Diphenyl ether;Amines;Building Blocks;C12;Chemical Synthesis;Nitrogen Compounds;Organic Building Blocks;API Intermediate
• Mol File: 93-67-4.mol

Chemical Properties

• Melting Point: 41-44 °C(lit.)
• Boiling Point: 192°C/12mmHg(lit.)
• Flash Point: >230 °F
• Appearance: /
• Density: 1.26 g/cm³
• Vapor Pressure: 0.000239mmHg at 25°C
• Refractive Index: 1.627
• Storage Temp.: Store below +30°C.
• PKA: 3.08±0.10(Predicted)
• CAS DataBase Reference: 5-Chloro-2-phenoxyaniline(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Chloro-2-phenoxyaniline(93-67-4)
• EPA Substance Registry System: 5-Chloro-2-phenoxyaniline(93-67-4)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 2
• HazardClass: IRRITANT
• Hazardous Substances Data: 93-67-4(Hazardous Substances Data)

Usage

Uses

Used in Dye Production Industry:
5-Chloro-2-phenoxyaniline is used as an intermediate for the production of acid dyes, specifically for synthesizing dyes such as acid red 249, acid red 149, and acid blue 128. Its role in dye production is crucial for creating a range of vibrant colors in various applications.

Preparation

2,5-Dichloronitrobenzene and sodium condensation of phenol and 1-Chloro-4-(2-nitrophenoxy)benzene?reduction.

InChI:InChI=1/C12H10ClNO/c13-9-6-7-12(11(14)8-9)15-10-4-2-1-3-5-10/h1-8H,14H2

Upstream product

• 91-39-4 4-chloro-2-nitro-1-phenoxybenzene 
• 108-95-2 phenol 
• 139-02-6 sodium phenoxide 
• 89-61-2 2,5-dichloronitrobenzene 

Downstream Products

• 51230-49-0 2-chlorodibenzofuran 
• 862659-61-8 benzoic acid-(5-chloro-2-phenoxy-anilide) 
• 112071-11-1 5-chloro-2-phenoxy-benzenediazonium; chloride 
• 54585-19-2 4-bromo-5'-chloro-2'-phenoxybutyranilide 
• 37940-93-5 5-Chlor-2-phenoxitrifluormethansulfonanilid 
• 195073-74-6 3-Bromo-N-(5-chloro-2-phenoxy-phenyl)-propionamide 
• 152581-20-9 N-(5-chloro-2-phenoxyphenyl)acetamide 
• 932698-46-9 N-(5-chloro-2-phenoxyphenyl)-N-(2,5-dimethoxybenzyl)amine 
• 932698-45-8 N-(5-chloro-2-phenoxyphenyl)-N-(3,5-dimethoxybenzyl)amine 
• 195073-79-1 (3-Bromo-propyl)-(5-chloro-2-phenoxy-phenyl)-amine 

Relevant articles and documents

Synthesis method of 5-chlorine-2-phenoxyaniline and Beta molecular sieve used in synthesis method

The invention discloses a synthesis method of 5-chlorine-2-phenoxyaniline. The synthesis method comprises the following steps: 1) heating 2, 5-dichloronitrobenzene to be melted in a solvent-free state, adding a condensation phase transfer catalyst into the melted 2, 5-dichloronitrobenzene, then adding sodium hydroxide and phenol into the mixture and performing a reaction at the temperature of 60-130 DEG C for 3-5h; 2) cooling a reaction product, adding a solvent, hydrazine hydrate and a Beta molecular sieve reduction catalyst into the reaction product, heating the mixture to backflow and performing a reduction reaction; 3) after a backflow reaction in step 2) is ended, performing filtration to obtain the Beta molecular sieve reduction catalyst and filtrate, distilling the filtrate to obtain alcohol in the solvent, cooling to 15-20 DEG C, stirring the mixture for 3-5h, performing separation by crystallization and performing filtration, so as to obtain the 5-chlorine-2-phenoxyaniline asa filter cake. The 5-chlorine-2-phenoxyaniline is synthesized by adopting the method disclosed by the invention, the technical advantages of having no wastes and saving energy are achieved.

A 2 - amino - 4 - chlorodisilanes diphenyl ether (by machine translation)

The invention discloses a 2 - amino - 4 - chlorodisilanes ether of preparation method, comprises the following steps: the 2 - nitro - 4 - chlorodisilanes ether, six water of ferric chloride and active carbon dispersed in ethanol, then adding alkali to adjust the pH to 7 - 9, under the heating condition [...] drip water reduction reaction, the reaction after the end of the, through after-processed to obtain the 2 - amino - 4 - chlorodisilanes ether. The preparation method of mild reaction conditions, easy-to-control, the reaction apparatus is simple, the catalyst and the solvent can be recycled repeatedly, friendly to the environment, the product quality is stable, the purity is good, high yield, facilitates large scale production. (by machine translation)

ANTI-VIRAL COMPOUNDS

Compounds effective in inhibiting replication of Hepatitis C virus ( HCV ) or other viruses are disclosed. This invention is also directed to compositions comprising such compounds, coformulation or co-administration of such compounds with other anti-viral or therapeutic agents, processes and intermediates for the syntheses of such compounds, and methods of using such compounds for the treatment of HCV or other viral infections.

Synthesis and evaluation of antipsychotic activity of 11-(4-aryl-1- piperazinyl)-dibenz [b, f][1,4] oxazepines and their 8-chloro analogues

Atypical drugs reduce positive and negative symptoms of schizophrenia, without inducing EPS, but they exert other undesirable side effects. We have gone for synthesis of novel derivatives of Loxapine which are devoid of catalepsy and have decreased metabolic demethylation which is the prominent factor for bioavailability of the drug. While doing so we have also been successful in retaining the antipsychotic activity of the drug. Condensation of 8,11-dichlorodibenzoxazepine and 11-chlorodibenzoxazepine with 1-aryl piperazines was carried to give 8-chloro-11-(4-aryl-1-piperazinyl)-dibenz[b,f] [1,4]oxazepines and 11-(4-aryl-1-piperazinyl)-dibenz[b,f][1,4]oxazepines respectively. These derivatives were found as active as Clozapine.

New spermine and spermidine derivatives as potent inhibitors of trypanosoma cruzi trypanothione reductase

Several spermine and spermidine derivatives containing 2-amino diphenylsulfide substituents were prepared and tested for their inhibiting effects on Trypanosoma cruzi trypanothione reductase. IC50 values were assessed between 0.3 and 3 μM. Compound 32 (K(i) = 0.4 μM) is the most potent TR inhibitor described so far.

2-, 3-, 5-, 8-, 10- AND/OR 11-SUBSTITUTED DIBENZOXAZEPINE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND METHODS FOR TREATING PAIN

The present invention provides substituted dibenzoxazepine compounds of Formula I: STR1 which are useful as analgesic agents for the treatment of pain, pharmaceutical compositions comprising a therapeutically-effective amount of a compound of Formula I in combination with a pharmaceutically-acceptable carrier, and a method for eliminating or ameliorating pain in an animal comprising administering a therapeutically-effective amount of a compound of Formula I to the animal.