91-39-4

Basic information

• Product Name: 2-Nitro 4' Chloro Diphenyl Ether
• Synonyms: 2-Nitro 4' Chloro Diphenyl Ether;4-Chloro-2-nitro-1-phenoxybenzene
• CAS NO: 91-39-4
• Molecular Formula: C₁₂H₈ClNO₃
• Molecular Weight: 249.64982
• Mol File: 91-39-4.mol
• Article Data: 7

Chemical Properties

• Melting Point: 36-37℃
• Boiling Point: 334.5 °C at 760 mmHg
• Flash Point: 156.1 °C
• Appearance: /
• Density: 1.358
• Vapor Pressure: 0.000247mmHg at 25°C
• Refractive Index: 1.614
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-Nitro 4' Chloro Diphenyl Ether(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Nitro 4' Chloro Diphenyl Ether(91-39-4)
• EPA Substance Registry System: 2-Nitro 4' Chloro Diphenyl Ether(91-39-4)

Safety Data

• Hazardous Substances Data: 91-39-4(Hazardous Substances Data)

Usage

Chemical Properties

2-Nitro 4' Chloro Diphenyl Ether is yellow solid

Uses

2-Nitro-4-chloro-diphenyl Ether is used in the synthesis of TR inhibitors.

InChI:InChI=1/C12H8ClNO3/c13-9-6-7-12(11(8-9)14(15)16)17-10-4-2-1-3-5-10/h1-8H

Upstream product

• 139-02-6 sodium phenoxide 
• 89-61-2 2,5-dichloronitrobenzene 
• 108-95-2 phenol 
• 41513-04-6 2-chloro-5-bromonitrobenzene 

Downstream Products

• 51230-49-0 2-chlorodibenzofuran 
• 195073-79-1 (3-Bromo-propyl)-(5-chloro-2-phenoxy-phenyl)-amine 
• 195073-74-6 3-Bromo-N-(5-chloro-2-phenoxy-phenyl)-propionamide 
• 56966-65-5 (4-bromo-phenyl)-(4-chloro-2-nitro-phenyl)-ether 
• 93-67-4 5-chloro-2-phenoxyaniline 
• 85385-33-7 5-chloro-2-phenoxyphenylisocyanate 

Relevant articles and documents

Synthesis method of 5-chlorine-2-phenoxyaniline and Beta molecular sieve used in synthesis method

The invention discloses a synthesis method of 5-chlorine-2-phenoxyaniline. The synthesis method comprises the following steps: 1) heating 2, 5-dichloronitrobenzene to be melted in a solvent-free state, adding a condensation phase transfer catalyst into the melted 2, 5-dichloronitrobenzene, then adding sodium hydroxide and phenol into the mixture and performing a reaction at the temperature of 60-130 DEG C for 3-5h; 2) cooling a reaction product, adding a solvent, hydrazine hydrate and a Beta molecular sieve reduction catalyst into the reaction product, heating the mixture to backflow and performing a reduction reaction; 3) after a backflow reaction in step 2) is ended, performing filtration to obtain the Beta molecular sieve reduction catalyst and filtrate, distilling the filtrate to obtain alcohol in the solvent, cooling to 15-20 DEG C, stirring the mixture for 3-5h, performing separation by crystallization and performing filtration, so as to obtain the 5-chlorine-2-phenoxyaniline asa filter cake. The 5-chlorine-2-phenoxyaniline is synthesized by adopting the method disclosed by the invention, the technical advantages of having no wastes and saving energy are achieved.

ANTI-VIRAL COMPOUNDS

Compounds effective in inhibiting replication of Hepatitis C virus ( HCV ) or other viruses are disclosed. This invention is also directed to compositions comprising such compounds, coformulation or co-administration of such compounds with other anti-viral or therapeutic agents, processes and intermediates for the syntheses of such compounds, and methods of using such compounds for the treatment of HCV or other viral infections.

New spermine and spermidine derivatives as potent inhibitors of trypanosoma cruzi trypanothione reductase

Several spermine and spermidine derivatives containing 2-amino diphenylsulfide substituents were prepared and tested for their inhibiting effects on Trypanosoma cruzi trypanothione reductase. IC50 values were assessed between 0.3 and 3 μM. Compound 32 (K(i) = 0.4 μM) is the most potent TR inhibitor described so far.