- Transfer hydrogenation of aldehydes and ketones catalyzed using an aminophosphinite POCNHpincer complex of Ni(ii)
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The aminophosphinite pincer complex (POCNH)NiBr was found to effectively catalyze the transfer hydrogenation of aldehydes and ketones with 2-propanol and KOtBu as a base, presenting a rare example of bifunctional nickel transfer hydrogenation catalysts. The transfer hydrogenation of aldehydes and ketones was found to be selective, tolerating a wide range of other functional groups, including those prone to reduction, such as esters, amides, alkenes, pyridines, and nitriles. The reactions were suggested to proceedviathe metal-ligand cooperative mechanism with an intermediacy of an amido (POCN)NiIIspecies.
- ?ztop?u, ?zgür,Hayrapetyan, Davit,Khalimon, Andrey Y.,Lyssenko, Konstantin A.,Segizbayev, Medet,Shakhman, Dinmukhamed
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p. 11950 - 11957
(2020/09/21)
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- NOVEL COMPOUNDS
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Compounds of formula (I) described herein are inhibitors of the phosphodiesterase 4 (PDE4) enzyme and muscarinic M3 receptor antagonists and are useful for the prevention and/or treatment of diseases of the respiratory tract characterized by airway obstru
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Page/Page column
(2014/06/23)
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- 4-amino-thieno[3,2-c] pyridine-7-carboxylic acid derivatives
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The present invention relates to compounds of the formula medicaments containing them and the use of these compounds as pharmaceutically active agents. The compounds exhibit activity as Raf kinase inhibitors and therefore may be useful for the treatment of diseases mediated by said kinases, especially as anticancer agents.
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Page/Page column 39
(2010/11/26)
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- Thiourea-catalyzed transfer hydrogenation of aldimines
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The present letter reports on the thiourea-catalyzed transfer hydrogenation of imines through hydrogen-bonding activation with Hantzsch 1,4-dihydropyridine as the hydrogen source. A variety of aromatic as well as aliphatic aldimines can be reduced to give
- Zhang, Zhiguo,Schreiner, Peter R.
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p. 1455 - 1457
(2008/03/11)
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- Method of topically treating inflammation
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This invention describes a method of treating inflammation in warmblooded animals by topically administering an effective amount of benzylamine and its derivatives.
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