934188-81-5

Basic information

• Product Name: 5-(2,4-DIFLUOROPHENYL)-3-ISOXAZOLEMETHANOL
• Synonyms: 5-(2,4-DIFLUOROPHENYL)-3-ISOXAZOLEMETHANOL;[5-(2,4-Difluorophenyl)isoxazol-3-yl]methanol
• CAS NO: 934188-81-5
• Molecular Formula: C₁₀H₇F₂NO₂
• Molecular Weight: 211.17
• Mol File: 934188-81-5.mol

Chemical Properties

• Boiling Point: 340.4±37.0 °C(Predicted)
• Appearance: /
• Density: 1.380±0.06 g/cm3(Predicted)
• PKA: 12.94±0.10(Predicted)
• CAS DataBase Reference: 5-(2,4-DIFLUOROPHENYL)-3-ISOXAZOLEMETHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(2,4-DIFLUOROPHENYL)-3-ISOXAZOLEMETHANOL(934188-81-5)
• EPA Substance Registry System: 5-(2,4-DIFLUOROPHENYL)-3-ISOXAZOLEMETHANOL(934188-81-5)

Safety Data

• Hazardous Substances Data: 934188-81-5(Hazardous Substances Data)

Upstream product

• 1105191-49-8 C₁₁H₇F₂NO₃ 
• 1119299-61-4 C₁₁H₈F₂O₄ 
• 364-83-0 2',4'-difluoroacetophenone 
• 934188-80-4 ethyl 5-(2,4-difluorophenyl)isoxazole-3-carboxylate 

Downstream Products

• 934188-82-6 [5-(2,4-difluorophenyl)-3-isoxazolyl]methyl acetate 

Relevant articles and documents

Design, synthesis and bioactivities of novel isoxazole-containing pyrazole oxime derivatives

In this study, in order to find novel biologically active pyrazole oxime derivatives, twenty-eight new pyrazole oxime compounds containing a substituted isoxazole ring were synthesized and evaluated for their acaricidaland insecticidal activities. Bioassays exhibited that some target compounds indicated good acaricidal and insecticidal activities against Tetranychus cinnabarinus, Aphis medicaginis, Mythimna separata, and Nilaparvata lugens. Especially, compounds 9c, 9h, 9u, and 9v showed 100.00%, 90.56%, 90.78%, and 90.62% insecticidal activities against A. medicaginis at the concentration of 20 μg/mL, respectively, compounds 9k and 9u had 70.86% and 100.00% insecticidal activities against M. separata at 20 μg/mL, respectively.

NITROGEN-CONTAINING HETEROCYCLIC COMPOUND AND PHARMACEUTICAL APPLICATION THEREOF

It is intended to provide a compound represented by the general formula (I): (I) (wherein all the symbols are as defined in the description) which has a p38 MAP kinase inhibitory activity, a salt thereof, an N-oxide thereof, a solvate thereof, or a prodrug thereof. The compound of the invention is useful for preventing or treating a disease in which the abnormal production of a cytokine such as an inflammatory cytokine or a chemokine or overreaction to them is considered to be involved in the cause and aggravation of pathological conditions, in other words, an inflammatory disease, a respiratory disease, a cardiovascular disease, a central nervous system disease or the like, which is a cytokine-mediated disease.