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(2-nitro-5-phenoxyphenyl)methanol is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 946130-80-9 Structure
  • Basic information

    1. Product Name: (2-nitro-5-phenoxyphenyl)methanol
    2. Synonyms: (2-nitro-5-phenoxyphenyl)methanol
    3. CAS NO:946130-80-9
    4. Molecular Formula:
    5. Molecular Weight: 245.235
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 946130-80-9.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: (2-nitro-5-phenoxyphenyl)methanol(CAS DataBase Reference)
    10. NIST Chemistry Reference: (2-nitro-5-phenoxyphenyl)methanol(946130-80-9)
    11. EPA Substance Registry System: (2-nitro-5-phenoxyphenyl)methanol(946130-80-9)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 946130-80-9(Hazardous Substances Data)

946130-80-9 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 946130-80-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,4,6,1,3 and 0 respectively; the second part has 2 digits, 8 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 946130-80:
(8*9)+(7*4)+(6*6)+(5*1)+(4*3)+(3*0)+(2*8)+(1*0)=169
169 % 10 = 9
So 946130-80-9 is a valid CAS Registry Number.

946130-80-9Relevant articles and documents

4-Substituted 2-amino-3,4-dihydroquinazolines with a 3-hairpin turn side chain as novel inhibitors of BACE-1

Chen, Grace Shiahuy,Chern, Ji-Wang,Hsieh, Chen-En,Hung, Pei-Yun,Jagtap, Ajit Dhananjay,Kondekar, Nagendra B.,Yang, Chia-Ron

, (2020/01/11)

Herein, we report the identification, design, and synthesis of a series of 4-substituted 2-amino-3,4-dihydroquinazolines with hairpin turn side chains as novel inhibitors of BACE-1. The dihydroquinazoline derivatives were rationally designed by modifying the amide group and relocating the α -hydrophobic substituent on the hairpin turn side chain of lead compound 2 to the C4-position on the 3,4-dihydroquinazoline scaffold to facilitate interactions with the S1, S2 and S1′ subsites of BACE-1. Among these derivatives, two compounds exhibited potent BACE-1 inhibitory activity: 4-methyl-substituted (22a, BACE-1 CFA IC50 = 0.38 μM; BACE-1 WCA IC50 = 0.14 μM) and 4-cyclohexylmethyl-substituted (22b, BACE-1 CFA IC50 = 0.49 μM; BACE-1 WCA IC50 = 0.14 μM) 2-amino-3,4-dihydroquinazoline, each bearing a side chain of N-cyclohexyl-N-((1-methyl-1H-pyrazol-4-yl)methyl amide. The results suggest that the structural modifications maintain the hairpin turn topology similar to that of compound 2 and provide an additional interaction with the S2 subsite.

2-AMINO-QUINOLINE DERIVATIVES USEFUL AS INHIBITORS OF BETA-SECRETASE (BACE)

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Page/Page column 39, (2008/12/07)

The present invention is directed to 2-amino-quinoline derivatives, pharmaceutical compositions containing them and their use in the treatment of Alzheimer's disease (AD) and related disorders. The compounds of the invention are inhibitors of β-secretase, also known as β-site cleaving enzyme and BACE, BACE1, Asp2 and memapsin2.

2-AMINO-3,4-DIHYDRO-QUINOLINE DERIVATIVES USEFUL AS INHIBITORS OF BETA-SECRETASE (BACE)

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Page/Page column 30, (2010/11/28)

The present invention is directed to 2-amino-3,4-dihydro-quinoline derivatives, pharmaceutical compositions containing them and their use in the treatment of Alzheimer's disease (AD) and related disorders. The compounds of the invention are inhibitors of β-secretase, also known as β-site cleaving enzyme and BACE, BACE1, Asp2 and memapsin2.

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