946130-80-9

Basic information

• Product Name: (2-nitro-5-phenoxyphenyl)methanol
• Synonyms: (2-nitro-5-phenoxyphenyl)methanol
• CAS NO: 946130-80-9
• Molecular Weight: 245.235
• Mol File: 946130-80-9.mol

Chemical Properties

• CAS DataBase Reference: (2-nitro-5-phenoxyphenyl)methanol(CAS DataBase Reference)
• NIST Chemistry Reference: (2-nitro-5-phenoxyphenyl)methanol(946130-80-9)
• EPA Substance Registry System: (2-nitro-5-phenoxyphenyl)methanol(946130-80-9)

Safety Data

• Hazardous Substances Data: 946130-80-9(Hazardous Substances Data)

Upstream product

• 548798-25-0 2-nitro-5-phenoxybenzaldehyde 
• 108-95-2 phenol 
• 395-81-3 5-fluoro-2-nitrobenzaldehyde 

Downstream Products

• 946130-81-0 2-chloromethyl-1-nitro-4-phenoxy-benzene 

Relevant articles and documents

4-Substituted 2-amino-3,4-dihydroquinazolines with a 3-hairpin turn side chain as novel inhibitors of BACE-1

Herein, we report the identification, design, and synthesis of a series of 4-substituted 2-amino-3,4-dihydroquinazolines with hairpin turn side chains as novel inhibitors of BACE-1. The dihydroquinazoline derivatives were rationally designed by modifying the amide group and relocating the α -hydrophobic substituent on the hairpin turn side chain of lead compound 2 to the C4-position on the 3,4-dihydroquinazoline scaffold to facilitate interactions with the S1, S2 and S1′ subsites of BACE-1. Among these derivatives, two compounds exhibited potent BACE-1 inhibitory activity: 4-methyl-substituted (22a, BACE-1 CFA IC50 = 0.38 μM; BACE-1 WCA IC50 = 0.14 μM) and 4-cyclohexylmethyl-substituted (22b, BACE-1 CFA IC50 = 0.49 μM; BACE-1 WCA IC50 = 0.14 μM) 2-amino-3,4-dihydroquinazoline, each bearing a side chain of N-cyclohexyl-N-((1-methyl-1H-pyrazol-4-yl)methyl amide. The results suggest that the structural modifications maintain the hairpin turn topology similar to that of compound 2 and provide an additional interaction with the S2 subsite.

2-AMINO-QUINOLINE DERIVATIVES USEFUL AS INHIBITORS OF BETA-SECRETASE (BACE)

The present invention is directed to 2-amino-quinoline derivatives, pharmaceutical compositions containing them and their use in the treatment of Alzheimer's disease (AD) and related disorders. The compounds of the invention are inhibitors of β-secretase, also known as β-site cleaving enzyme and BACE, BACE1, Asp2 and memapsin2.

2-AMINO-3,4-DIHYDRO-QUINOLINE DERIVATIVES USEFUL AS INHIBITORS OF BETA-SECRETASE (BACE)

The present invention is directed to 2-amino-3,4-dihydro-quinoline derivatives, pharmaceutical compositions containing them and their use in the treatment of Alzheimer's disease (AD) and related disorders. The compounds of the invention are inhibitors of β-secretase, also known as β-site cleaving enzyme and BACE, BACE1, Asp2 and memapsin2.