950-81-2Relevant articles and documents
Cycloaddition Reaction of in Situ Formed Azaoxyallyl Cations with Aldehydes: An Approach to Oxazolidin-4-ones
Zhang, Kaifan,Yang, Chi,Yao, Hequan,Lin, Aijun
supporting information, p. 4618 - 4621 (2016/09/28)
A novel [3 + 2] cycloaddition reaction between in situ formed azaoxyallyl cations and aldehydes has been developed. This concise method allows the rapid formation of a number of oxazolidin-4-ones in high yields with good functional group tolerance at room temperature. Further transformation and late-stage modifications of drug molecules could also be achieved in good yields, highlighting the potential utility of the reaction.
Synthesis, antiviral, cytotoxicity and antitumor evaluations of A4 type of porphyrin derivatives
Fadda, Ahmed A.,El-Mekawy, Rasha E.,El-Shafei, Ahmed I.
, p. 753 - 768 (2015/10/29)
This manuscript describes the synthesis of a new series of porphyrin structures 4a-4m, 7, 9, 12 and 14. These structures were investigated against two types of viruses such as HIV-1 and HSV-1. Also they were screened for their antitumor activity. Among all tested compounds, it was found that compound 4b showed a high activity against HIV-1 and HSV-1 and against four different tumor cell lines. Most of the tested compounds showed a moderate degree of a potent antimicrobial activity. The structure of these compounds was confirmed on the basis of their analytical and spectral data such as UV-vis, IR, 13C NMR, 1H NMR spectroscopy and mass spectral data.
Synthesis, antiviral, cytotoxicity and antitumor evaluations of A4 type of porphyrin derivatives
Fadda, Ahmed A.,El-Mekawy, Rasha E.,El-Shafei, Ahmed I.
, p. 753 - 768 (2016/01/09)
This manuscript describes the synthesis of a new series of porphyrin structures 4a-4m, 7, 9, 12 and 14. These structures were investigated against two types of viruses such as HIV-1 and HSV-1. Also they were screened for their antitumor activity. Among all tested compounds, it was found that compound 4b showed a high activity against HIV-1 and HSV-1 and against four different tumor cell lines. Most of the tested compounds showed a moderate degree of a potent antimicrobial activity. The structure of these compounds was confirmed on the basis of their analytical and spectral data such as UV-vis, IR, 13C NMR, 1H NMR spectroscopy and mass spectral data.
Synthesis of Some Antipyryl Methines. I. Asymmetrical Antipyryl Methines
Kokkinos, Konst.,Markopoulos, Chr.
, p. 543 - 553 (2007/10/02)
A new series of asymmetrical antipyryl dimethine cyanines 2-7 was synthesized, starting with antipyrine aldehyde 1 and methylcarbenium salts, and the color change of the dyes was investigated as a function of the carbene moiety.
