952138-19-1

Basic information

• Product Name: 4-Chloro-7-Methoxy-1,6-naphthyridine
• Synonyms: 4-Chloro-7-Methoxy-1,6-naphthyridine;4-Chloro-7-Methoxy-1,6-na...
• CAS NO: 952138-19-1
• Molecular Formula: C₉H₇ClN₂O
• Molecular Weight: 194.61768
• EINECS: 200-589-5
• Mol File: 952138-19-1.mol

Chemical Properties

• Boiling Point: 303.4±37.0 °C(Predicted)
• Appearance: /
• Density: 1.333±0.06 g/cm3(Predicted)
• PKA: 3.35±0.30(Predicted)
• CAS DataBase Reference: 4-Chloro-7-Methoxy-1,6-naphthyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Chloro-7-Methoxy-1,6-naphthyridine(952138-19-1)
• EPA Substance Registry System: 4-Chloro-7-Methoxy-1,6-naphthyridine(952138-19-1)

Safety Data

• Hazardous Substances Data: 952138-19-1(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
4-Chloro-7-Methoxy-1,6-naphthyridine is used as an intermediate in the synthesis of various pharmaceuticals for its potential biological activity. It contributes to the development of new drugs with specific therapeutic properties.
Used in Agrochemical Industry:
In the agrochemical industry, 4-Chloro-7-Methoxy-1,6-naphthyridine is used as a precursor in the production of agrochemicals, such as pesticides and herbicides, to enhance their effectiveness in controlling pests and weeds.
Used in Organic Chemistry Research:
4-Chloro-7-Methoxy-1,6-naphthyridine is utilized as a building block in organic chemistry reactions to create new compounds with specific properties. It aids researchers in exploring novel chemical structures and their potential applications in various fields.
Used in Chemical Synthesis:
4-Chloro-7-Methoxy-1,6-naphthyridine is employed as a key component in the synthesis of complex organic molecules, enabling the development of innovative materials and compounds with unique characteristics for various applications.

Upstream product

• 20265-39-8 4-amino-2-methoxypyridine 
• 215364-85-5 3-bromo-2-chloro-pyridin-4-ylamine 
• 952138-17-9 8-bromo-7-methoxy-1,4-dihydro-1,6-naphthyridin-4-one 
• 952138-18-0 7-methoxy-1,4-dihydro-1,6-naphthyridin-4-one 
• 952138-16-8 5-[[(3-bromo-2-methoxypyridin-4-yl)amino]methylidene]-2,2-dimethyl-1,3-dioxane-4,6-dione 
• 215364-86-6 3-bromo-2-methoxypyridin-4-ylamine 
• 14432-12-3 4-Amino-2-chloropyridine 

Downstream Products

• 952138-20-4 tert-butyl 2-[2-methoxy-4-(7-methoxy-1,6-naphthyridin-4-yloxy)phenyl]acetate 
• 952138-15-7 2-[2-methoxy-4-(7-methoxy-1,6-naphthyridin-4-yloxy)phenyl]acetic acid 

Relevant articles and documents

PYRIDO-AZAHETERECYDIC COMPOUND AND PREPARATION METHOD AND USE THEREOF

The present invention discloses a pyrido-azacyclic compound represented by formula I, an isomer thereof, a pharmaceutically acceptable salt or a pharmaceutically acceptable solvate thereof, a preparation process thereof and a composition comprising the compound, and a use thereof as a multi-target protein kinase inhibitor in the preparation of a medicament for the treatment of diseases that are associated with protein kinase, especially c-Met, such as cancer and the like. The compound represented by formula I has potent inhibitory activity on tumor cells with overexpression of c-Met kinase, can effectively target c-Met-mediated signaling pathway, and can be used in the treatment of diseases such as cancer and the like that is caused by the overexpression of c-Met kinase.

Aurora Kinase Modulators and Method of Use

The present invention relates to chemical compounds having a general formula I wherein A1-8, D′, L1, L2, R1, R6-8 and n are defined herein, and synthetic intermediates, which are capable of modulating various protein kinase receptor enzymes and, thereby, influencing various disease states and conditions related to the activities of such kinases. For example, the compounds are capable of modulating Aurora kinase thereby influencing the process of cell cycle and cell proliferation to treat cancer and cancer-related diseases. The invention also includes pharmaceutical compositions, including the compounds, and methods of treating disease states related to the activity of Aurora kinase.

AURORA KINASE MODULATORS AND METHOD OF USE

The present invention relates to chemical compounds having a general formula I {INSERT STRUCTURE HERE} wherein A1-8, D,, L1, L2, R1, R6-8 and n are defined herein, and synthetic intermediates, which are capable of modulating various protein kinase receptor enzymes and, thereby, influencing various disease states and conditions related to the activities of such kinases. For example, the compounds are capable of modulating Aurora kinase thereby influencing the process of cell cycle and cell proliferation to treat cancer and cancer-related diseases. The invention also includes pharmaceutical compositions, including the compounds, and methods of treating disease states related to the activity of Aurora kinase.

FUSED HETEROCYCLIC DERIVATIVES AND METHODS OF USE

Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

NAPHTHYRIDINE DERIVATIVES AS ANTI-CANCER AGENTS

The invention concerns naphthyridine derivatives of Formula (I): or a pharmaceutically-acceptable salt thereof, wherein each of X1, p, R1, G1, G2, q, R2, R3, R4, R5, Ring A, r and R6 has any of the meanings defined hereinbefore in the description; pharmaceutical compositions containing them and their use in the treatment of cell proliferative disorders or disease states associated with angiogenesis and/or vascular permeability.