- CAN-mediated rearrangement of 4-benzhydrylidenepiperidines
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Several 1-substituted phenyl-(4-phenylpiperidin-4-yl)methanones are synthesized in modest overall yields starting from the reaction of different 1-substituted 4-benzhydrylidenepiperidines via CAN-mediated rearrangement. This facile strategy was also used to synthesize meperidine analog.
- Chang, Meng-Yang,Wu, Tsun-Cheng,Lin, Chun-Yu,Hung, Ching-Yi
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p. 8347 - 8350
(2007/10/03)
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- Synthesis of terfenadine carboxylate
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A synthesis of terfenadine carboxylate, 1, a metabolite of terfenadine 2, is described. In the key step, the sodium salt of 2-(4-bromo-phenyl)-2-methylpropionic acid, 7, was lithiated via a metal-halogen exchange using t-BuLi and subsequently condensed with 4-[4-(hydroxydiphenylmethylpiperidin-1-yl]butyraldehyde, 5, to afford terfenadine carboxylate, 1.
- Patel, Sunil,Waykole, Liladhar,Repic, Oljan,Chen, Kau-Ming
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p. 4699 - 4710
(2007/10/03)
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