97095-85-7Relevant articles and documents
A stable isotope labeled 2 - isopropyl thioxanthone and its synthesis method
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Paragraph 0051; 0074-0076; 0082-0084; 0090-0092, (2018/04/21)
The invention relates to stable isotopic labeled 2-isopropylthioxanthone and a synthetic method thereof. The stable isotopic labeled 2-isopropylthioxanthone is 2-isopropylthioxanthone labeled by D or 13C. The synthetic method comprises the following steps of using benzene and acetone which are labeled by stable isotopic D or 13C as raw materials; reacting the benzene and the acetone with magnesium to obtain Grignard reagent after benzene bromination; performing reduction and hydroxide radical bromination on the acetone to obtain 2-bromic propane; performing Grignard reaction to obtain isopropyl benzene; reacting the isopropyl benzene with dithio-salicylic acid; and synthesizing to obtain the 2-isopropylthioxanthone labeled by the stable isotopic D or 13C. Compared with the prior art, the stable isotopic labeled 2-isopropylthioxanthone has the advantages that a process route is simple, the 2-isopropylthioxanthone is easy to synthesize, products are easy to separate and purify, the chemical purity of the products is above 99.0%, isotope abundance is above 98.0% atom, requirements of trace detection in the field of food safety can be met fully, and economical efficiency and using value are excellent.
Synthesis of isotopically labelled 2-isopropylthioxanthone from 2,2′-dithiosalicylic acid and deuterium cumene
Fang, Chao,Yang, Weicheng,Yang, Chao,Wang, Haoran,Sun, Kai,Luo, Yong
, p. 313 - 316 (2016/07/11)
Two efficient synthetic routes of stable deuterium labelled 2-isopropylthioxanthone were presented with 98.1% and 98.8% isotopic abundance in acceptable yields and excellent chemical purities. Their structures and the isotope-abundance were confirmed according to proton nuclear magnetic resonance and liquid chromatography–mass spectrometry.
An alternative route to electrophilic substitution. 2. Aromatic alkylation in the ion neutral complexes formed upon addition of gaseous arenium ions to olefins
Aschi, Massimiliano,Attinà, Marina,Cacace, Fulvio
, p. 12832 - 12839 (2007/10/03)
The joint application of mass spectrometric and radiolytic techniques has allowed demonstration of an alternative route to electrophilic aromatic substitution operative in the gas phase, where the Wheland intermediate is formed within the ion-neutral complex (INC) formed upon addition of an arenium ion to an olefin. Experiments involving several representative pairs of arenium ions XC6H6+ (X = H, CH3, CF3) and olefins (C3H6, iC4H8, cC5H8) have provided conclusive evidence for the operation of the above reaction sequence and hence for the occurrence of intracomplex alkylation. The peculiar mechanistic features of the reaction fit a model that identifies the relative basicity of the arene and of the olefin associated in any given INC as the key kinetic factor. The model accounts for the seemingly paradoxical observation that the alkylated products from less activated substrates are formed at relatively higher rates and for the occurrence of consecutive alkylation steps, yielding polyalkylated products of the less activated substrates. The relevance of the work to the theory of the aromatic substitution as a new entry into the reaction manifold of Friedel-Crafts alkylation and to gas-phase ion chemistry, as an irrefutable demonstration of the kinetic role of INCs is briefly discussed.
