- A class of FLT3 kinase inhibitors, preparation and application thereof
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The invention relates to a class of FLT3 kinase inhibitors, preparation and application thereof, wherein specifically the compound has a structure represented by a formula (I), and all groups and substituents are defined in the specification. The invention also discloses a preparation method of the compound, and application of the compound in inhibition of FLT3.
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Paragraph 0234; 0237-0240
(2020/06/20)
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- QUINOLINE AND QUINAZOLINE COMPOUNDS AND METHODS OF USE THEREOF
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Compounds and methods for their preparation and use as therapeutic or prophylactic agents, fo example for treatment of cancer, bacterial or viral diseases by targeting Ectonucleotide Pyrophosphatase/Phosphodiesterase- 1 (ENPP1).
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Paragraph 00335-00336
(2020/10/09)
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- Imidazopyridazine IRAK4 inhibitor, and preparation method and application thereof
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The invention belongs to the field of medicines, and especially relates to an imidazopyridazine compound or a pharmaceutically acceptable salt thereof, a preparation method thereof, and an applicationof a medicinal composition of the compound or the salt in the treatment of tumors, inflammations, immunity and other diseases. The imidazopyridazine compound is a novel protein kinase IRAK4 inhibitor, and can selectively inhibit IRAK4 and downstream signaling pathways thereof. The compound has the structural formula I.
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Paragraph 0252; 0253; 0254
(2018/03/26)
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- PYRROLONE OR PYRROLIDINONE MELANIN CONCENTRATING HORMONE RECEPTOR-1 ANTAGONISTS
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The present invention provides compounds of Formula (I): as defined in the specification and compositions comprising any of such novel compounds. These compounds are melanin concentrating hormone receptor-1 (MCHR1) antagonists which may be used as medicaments.
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Paragraph 00206
(2014/03/26)
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- IMIDAZOPYRAZINE SYK INHIBITORS
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Certain imidazopyrazines and pharmaceutical compositions thereof are provided herein. Methods of treating patients suf-fering from certain diseases and disorders responsive to the inhibition of Syk activity, which comprises administering to such patients an amount of an imidazopyrazine compound effective to reduce signs or symptoms of the disease or dis-order are provided.
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Paragraph 0219
(2014/01/08)
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- Discovery of 2,4-bis-arylamino-1,3-pyrimidines as insulin-like growth factor-1 receptor (IGF-1R) inhibitors
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The insulin-like growth factor-1 receptor (IGF-1R) plays an important role in the regulation of cell growth and differentiation, and in protection from apoptosis. IGF-1R has been shown to be an appealing target for the treatment of human cancer. Herein, w
- Buchanan, John L.,Newcomb, John R.,Carney, David P.,Chaffee, Stuart C.,Chai, Lilly,Cupples, Rod,Epstein, Linda F.,Gallant, Paul,Gu, Yan,Harmange, Jean-Christophe,Hodge, Kathy,Houk, Brett E.,Huang, Xin,Jona, Janan,Joseph, Smriti,Jun, H. Toni,Kumar, Rakesh,Li, Chun,Lu, John,Menges, Tom,Morrison, Michael J.,Novak, Perry M.,Van Der Plas, Simon,Radinsky, Robert,Rose, Paul E.,Sawant, Satin,Sun, Ji-Rong,Surapaneni, Sekhar,Turci, Susan M.,Xu, Keyang,Yanez, Evelyn,Zhao, Huilin,Zhu, Xiaotian
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scheme or table
p. 2394 - 2399
(2011/05/15)
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- 4-ARYL-2-AMINO-PYRIMIDINES OR 4-ARYL-2-AMINOALKYL-PYRIMIDINES AS JAK-2 MODULATORS AND METHODS OF USE
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This invention relates to certain pyrimidine derivative inhibitors of JAK-2, having Formula (I): wherein D, E, L, Z, R1, R2, R25, and n1 are as defined in the specification, pharmaceutically acceptable salts thereof, pharmaceutical compositions thereof, and methods of use thereof.
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Page/Page column 236
(2008/06/13)
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- THIAZOLOPYRIDINONE DERIVATES AS MCH RECEPTOR ANTAGONISTS
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The present invention relates to a melanin concentrating hormone antagonist compound of formula (I); wherein w, R1, q, p, R2, t, Ar1, L1, R3 and R4 are as defined, or a pharmaceutically acceptable salt, solvate, or enantiomer thereof useful in the treatment, prevention or amelioration of symptoms associated with obesity and related diseases.
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Page/Page column 49
(2008/06/13)
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- MORPHOLINYLANILINOQUINAZO- LINE DERIVATIVES FOR USE AS ANTIVIRAL AGENTS
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Compounds of formula (Ia) are found to be active in inhibiting replication of flaviviridae viruses, wherein R1, R2, R3 and R4 are as defined in the claims.
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Page/Page column 34
(2008/06/13)
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- Amino-substituted pyrimidinyl derivatives and methods of use
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The invention encompasses compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions, uses and methods for prophylaxis and treatment of cancer.
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- Assignment of Quaternary Carbons via Two-Bond Heteronuclear Selective NOE Difference, a Useful Structure Elucidation Aid
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Very low power irradiation of suitable narrow peaks in the proton frequency range generated NOE enhancement in neighbouring quaternary carbons, positioned two bonds from the irradiated protons.Subsequent FID acquisition under normal broad band decoupling
- Sanchez-Ferrando, Francisco
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p. 185 - 191
(2007/10/02)
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- NITROPHENYL ETHERS AS POSSIBLE PHOTOAFFINITY LABELS. THE NUCLEOPHILIC AROMATIC PHOTOSUBSTITUTION REVISITED.
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The photoreactions of nitrophenyl ethers with simple primary and secondary amines show a remarkable nucleophile influence on the reaction orientation.Calculations indicate a change from charge controlled to frontier orbital controlled reactions moving from smaller to larger amines.
- Cervello, J.,Figueredo, M.,Marquet, J.,Moreno-Manas, M.,Bertran, J.,Lluch, J. M.
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p. 4147 - 4150
(2007/10/02)
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