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Cas Database

100-90-3

100-90-3

Identification

Synonyms:Acetanilide,4'-[(4,6-dimethyl-2-pyrimidinyl)sulfamoyl]- (6CI,7CI,8CI);Acetanilide, p-(4,6-dimethyl-2-pyrimidylsulfamyl)-(4CI);4'-[(4,6-Dimethyl-2-pyrimidinyl)sulfamoyl]acetanilide;Acetylsulfamethazine;N-Acetylsulfamethazine;N4-Acetylsulfadimidine;N4-Acetylsulfamethazine;N4-Acetylsulmet;

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Safety information and MSDS view more

  • Signal Word:no data available

  • Hazard Statement:no data available

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

  • Fire-fighting measures: Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

Supplier and reference price view more

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  • Manufacture/Brand:TRC
  • Product Description:N-AcetylSulfamethazine
  • Packaging:5mg
  • Price:$ 135
  • Delivery:In stock
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  • Manufacture/Brand:Medical Isotopes, Inc.
  • Product Description:N-AcetylSulfamethazine
  • Packaging:100 mg
  • Price:$ 2000
  • Delivery:In stock
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  • Manufacture/Brand:Biosynth Carbosynth
  • Product Description:N-Acetyl sulfamethazine
  • Packaging:10 mg
  • Price:$ 320
  • Delivery:In stock
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  • Manufacture/Brand:Biosynth Carbosynth
  • Product Description:N-Acetyl sulfamethazine
  • Packaging:5 mg
  • Price:$ 200
  • Delivery:In stock
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  • Manufacture/Brand:Biosynth Carbosynth
  • Product Description:N-Acetyl sulfamethazine
  • Packaging:25 mg
  • Price:$ 650
  • Delivery:In stock
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  • Manufacture/Brand:Biosynth Carbosynth
  • Product Description:N-Acetyl sulfamethazine
  • Packaging:2 mg
  • Price:$ 100
  • Delivery:In stock
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  • Manufacture/Brand:Biosynth Carbosynth
  • Product Description:N-Acetyl sulfamethazine
  • Packaging:1 mg
  • Price:$ 65
  • Delivery:In stock
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  • Manufacture/Brand:Aronis compounds
  • Product Description:N-(4-{[(4,6-dimethyl-2-pyrimidinyl)amino]sulfonyl}phenyl)acetamide
  • Packaging:20mg
  • Price:$ 30
  • Delivery:In stock
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  • Manufacture/Brand:Aronis compounds
  • Product Description:N-(4-{[(4,6-dimethyl-2-pyrimidinyl)amino]sulfonyl}phenyl)acetamide
  • Packaging:1mg
  • Price:$ 12
  • Delivery:In stock
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  • Manufacture/Brand:American Custom Chemicals Corporation
  • Product Description:N-ACETYL SULFAMETHAZINE 95.00%
  • Packaging:5MG
  • Price:$ 338.8
  • Delivery:In stock
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Relevant articles and documentsAll total 1 Articles be found

The metabolism of four sulphonamides in cows

Nielsen

, p. 1039 - 1045 (1973)

The metabolism of sulphanilamide, sulphadimidine (4,6 dimethyl 2 sulphanilamido pyrimidine), sulphamethoxazole (5 methyl 3 sulphanilamidoisoxazole) and sulphadoxine (5,6 dimethoxy 4 sulphanilamidopyrimidine) given by intravenous injection has been examined in cows. The sulphonamides were present mainly as unchanged drugs in blood samples collected 2 hr after administration. The sulphonamides were excreted in the milk partly as unchanged drugs and partly as conjugated metabolites whereas only small amounts were excreted as the N4 acetyl derivatives. The unchanged drug and the N4 acetyl derivative were the major constituents in urine samples after administration of sulphanilamide, sulphamethoxazole and sulphadoxine. Besides the unchanged drug, the N4 acetyl derivative and the conjugated metabolites, three further metabolites of sulphadimidine were isolated from urine samples and identified. They were 5 hydroxy 4,6 dimethyl 2 sulphanilamidopyrimidine, 4 hydroxymethyl 6 methyl 2 sulphanilamido pyrimidine and sulphaguanidine.

Process route upstream and downstream products

Process route

sulfadimesine
57-68-1

sulfadimesine

N-[4-(4,6-Dimethyl-pyrimidin-2-ylsulfamoyl)-phenyl]-acetamide
100-90-3

N-[4-(4,6-Dimethyl-pyrimidin-2-ylsulfamoyl)-phenyl]-acetamide

Conditions
Conditions Yield
2-Amino-4,6-dimethylpyrimidine
767-15-7,184433-59-8

2-Amino-4,6-dimethylpyrimidine

p-acetylaminobenzenesulfonyl chloride
121-60-8

p-acetylaminobenzenesulfonyl chloride

N-[4-(4,6-Dimethyl-pyrimidin-2-ylsulfamoyl)-phenyl]-acetamide
100-90-3

N-[4-(4,6-Dimethyl-pyrimidin-2-ylsulfamoyl)-phenyl]-acetamide

Conditions
Conditions Yield
2-chloro-4,6-dimethylpyrimidine
4472-44-0

2-chloro-4,6-dimethylpyrimidine

p-acetylaminobenzenesulfonamide
121-61-9

p-acetylaminobenzenesulfonamide

N-[4-(4,6-Dimethyl-pyrimidin-2-ylsulfamoyl)-phenyl]-acetamide
100-90-3

N-[4-(4,6-Dimethyl-pyrimidin-2-ylsulfamoyl)-phenyl]-acetamide

Conditions
Conditions Yield
With sodium carbonate;
With copper; potassium carbonate;
2-chloro-4,6-dimethylpyrimidine
4472-44-0

2-chloro-4,6-dimethylpyrimidine

N-[4-(4,6-Dimethyl-pyrimidin-2-ylsulfamoyl)-phenyl]-acetamide
100-90-3

N-[4-(4,6-Dimethyl-pyrimidin-2-ylsulfamoyl)-phenyl]-acetamide

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1: K2CO3; toluene
With potassium carbonate; toluene;
N-(4-{[(aminoiminomethyl)amino]sulfonyl}phenyl)acetamide
19077-97-5

N-(4-{[(aminoiminomethyl)amino]sulfonyl}phenyl)acetamide

acetylacetone
123-54-6,81235-32-7

acetylacetone

N-[4-(4,6-Dimethyl-pyrimidin-2-ylsulfamoyl)-phenyl]-acetamide
100-90-3

N-[4-(4,6-Dimethyl-pyrimidin-2-ylsulfamoyl)-phenyl]-acetamide

Conditions
Conditions Yield
acetylacetone
123-54-6,81235-32-7

acetylacetone

N-[4-(4,6-Dimethyl-pyrimidin-2-ylsulfamoyl)-phenyl]-acetamide
100-90-3

N-[4-(4,6-Dimethyl-pyrimidin-2-ylsulfamoyl)-phenyl]-acetamide

Conditions
Conditions Yield
1-amino-4-({[amino(imino)methyl]amino}sulfonyl)benzene
57-67-0,61116-95-8

1-amino-4-({[amino(imino)methyl]amino}sulfonyl)benzene

N-[4-(4,6-Dimethyl-pyrimidin-2-ylsulfamoyl)-phenyl]-acetamide
100-90-3

N-[4-(4,6-Dimethyl-pyrimidin-2-ylsulfamoyl)-phenyl]-acetamide

Conditions
Conditions Yield
(E)-4-(piperidino)pent-3-en-2-one
63913-41-7

(E)-4-(piperidino)pent-3-en-2-one

N-(4-{[(aminoiminomethyl)amino]sulfonyl}phenyl)acetamide
19077-97-5

N-(4-{[(aminoiminomethyl)amino]sulfonyl}phenyl)acetamide

N-[4-(4,6-Dimethyl-pyrimidin-2-ylsulfamoyl)-phenyl]-acetamide
100-90-3

N-[4-(4,6-Dimethyl-pyrimidin-2-ylsulfamoyl)-phenyl]-acetamide

Conditions
Conditions Yield
p-acetylaminobenzenesulfonamide
121-61-9

p-acetylaminobenzenesulfonamide

4,6-dimethyl-2-phenoxy-pyrimidine
7220-71-5

4,6-dimethyl-2-phenoxy-pyrimidine

N-[4-(4,6-Dimethyl-pyrimidin-2-ylsulfamoyl)-phenyl]-acetamide
100-90-3

N-[4-(4,6-Dimethyl-pyrimidin-2-ylsulfamoyl)-phenyl]-acetamide

Conditions
Conditions Yield
acetamide
60-35-5

acetamide

(4,6-dimethylpyrimid-2′-yl)-trimethylammonium chloride
77767-94-3

(4,6-dimethylpyrimid-2′-yl)-trimethylammonium chloride

4-acetylamino-benzenesulfonamide; monosodium salt
3079-36-5

4-acetylamino-benzenesulfonamide; monosodium salt

N-[4-(4,6-Dimethyl-pyrimidin-2-ylsulfamoyl)-phenyl]-acetamide
100-90-3

N-[4-(4,6-Dimethyl-pyrimidin-2-ylsulfamoyl)-phenyl]-acetamide

Conditions
Conditions Yield

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  • Finetech Industry Limited
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