767-15-7Relevant academic research and scientific papers
Synthesis of TiO2-Ag3PO4photocatalyst material with high adsorption capacity and photocatalytic activity: application in the removal of dyes and pesticides
Agyei-Tuffour, Benjamin,Efavi, Johnson K.,Manu, Gloria,Nyankson, Emmanuel
, p. 17032 - 17045 (2021/05/25)
The photocatalytic activity of TiO2can be enhanced by coupling it with other semiconductors and the semiconductor composites may find useful application in water treatment technologies. TiO2-Ag3PO4composites wer
Synthesis of 4,4′-Oxydibenzoic Acid Amides and Sulfonamides Containing 2-Arylaminopyrimidine Moieties
Ignatovich, Zh. V.,Ermolinskaya,Petushok,Katok, Ya. M.,Koroleva
, p. 2092 - 2097 (2021/02/09)
Abstract: New 4,4′-oxydibenzamides and sulfamoyl derivatives of 4,4′-oxydibenzoic acid containing pharmacophoric 2-arylaminopyrimidine fragments in the amide moiety have been synthesized. Acylation of amines of the pyrimidine series with 2-chlorosulfonyl-substituted 4,4′-oxydibenzoic acid gave the corresponding sulfonamides. Arylaminopyrimidine derivatives of 4,4′-oxydibenzamide were obtained in 75–87% yield by acylation of 3-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}anilines with 4,4′-oxydibenzoyl chloride. The reactivity of 4,4′-oxydibenzoyl chloride toward amines is discussed.
The performance and degradation mechanism of sulfamethazine from wastewater using IFAS-MBR
Hou, Huanhuan,Duan, Liang,Zhou, Beihai,Tian, Yuan,Wei, Jian,Qian, Feng
supporting information, p. 543 - 546 (2019/09/07)
Sulfamethazine (SMZ) is an important sulfonamide antibiotic. Although the concentration in the environment is small, it is harmful. The drug residues can be transferred, transformed or accumulated, affecting the growth of animals and plants. In this study, the integrated fixed-film activated sludge membrane bioreactor (IFAS-MBR) were constructed to investigate the performance and degradation mechanism of SMZ. The addition of SMZ had a significant impact on the removal of the chemical oxygen demand (COD) and ammonia nitrogen (NH4 +-N). The optimal operating conditions were hydraulic retention time (HRT) at 10 h and solid retention time (SRT) at 80 d, respectively. On this basis, the effects of different SMZ concentrations on nutrient removal, degradation, and sludge characteristics were compared. The removal efficiency of SMZ increased with the increase of SMZ concentration. The maximum removal rate was as high as 87%. The SMZ dosage also had an obvious effect on sludge characteristics. As the SMZ concentration increased, the extracellular polymer substances (EPS) concentration and the membrane resistance both decreased, which were beneficial for the reduction of membrane fouling. Finally, seven kinds of SMZ biodegradation intermediates were identified, and the possible degradation pathways were speculated. The microbial community results showed that the microbial diversity and richness in the reactor decreased after adding SMZ to the influent. The relative abundance of Bacteroidetes, Actinobacteria, Saccharibacteria and Nitrospirae increased at the phylum level. Sphingobacteria and Betaproteobacteria became dominant species at the class level. The relative abundance of norank-p-Saccharibacteria and Nitrospirae increased significantly, and norank-p-Saccharibacteria may be the dominant bacteria for SMZ degradation.
Ultrasound-assisted rapid synthesis of 2-aminopyrimidine and barbituric acid derivatives
Bayramo?lu, Duygu,Kurtay, Gülbin,Güllü, Mustafa
, p. 649 - 658 (2020/02/11)
Novel, inexpensive, and relatively expeditious procedure to achieve the synthesis of different 2-aminopyrimidine and barbituric acid derivatives is presented here, starting from readily available compounds such as guanidine hydrochloride, urea, 1,3-dialkylurea, or thiourea. Under ultrasonic irradiation, base-driven (Na2CO3, NaOH, or NaOC2H5) heterocyclization reactions of the aforementioned substrates with diethyl malonate, diethyl-2-alkyl malonate, pentane-2,4-dione, or ethyl-3-oxobutanoate yielded corresponding products. Significant advantages of this sonochemical synthetic protocol with regard to the conventional thermal methods include easy reaction setup and work-up steps, reasonably mild conditions, shorter reaction times (～30 min) and comparably high product yields. The characterization of the synthesized compounds was based on melting points, FT-IR, GC-MS, 1H-NMR techniques, and the obtained data were also checked from the previously published studies.
Imidazo[4,5-c]pyridine derivative and application thereof
-
Paragraph 0135; 0138; 0139; 0140, (2019/10/01)
The invention relates to a novel imidazo[4,5-c]pyridine derivative represented by a general formula I, and pharmaceutically acceptable salts, solvates or prodrugs of the novel imidazo[4,5-c]pyridine derivative, wherein the substituent R and R' are defined as in the specification. The invention also relates to an effect of the compound represented by the general formula I in inhibiting an NS5B RNA-dependent RNA polymerase (NS5B polymerase for short) which is necessary in a replication process of hepatitis c virus, also relates to an application of the compound, and pharmaceutically acceptable salts, hydrates or prodrugs of the compound in preparation of medicines for treating viral diseases, and especially relates to an application in preparation of medicines for treating and/or preventinghepatitis c.
Sulfonamide hapten, sulfonamide artificial antigen and their preparation methods and application
-
Paragraph 0071; 0073, (2019/06/30)
The invention relates to a sulfonamide hapten, a sulfonamide artificial antigen and their preparation methods and application. The sulfonamide hapten has a structure shown as formula (1) which is shown in the description, wherein n is an integer equal to 0, or greater than and equal to 1. The sulfonamide artificial antigen is made by coupling the hapten of the formula (1) and a carrier protein. Byimmunizing animals with the sulfonamide artificial antigen, specific antibodies with high efficacy and high sensitivity can be attained. The sulfonamide hapten and antibodies prepared with the same help provide a new means to establish a method to detect sulfonamides under high speed, good simplicity, low cost, good sensitivity and good specificity.
Photolysis of sulfamethazine using UV irradiation in an aqueous medium
Yi, Zhigang,Wang, Juan,Tang, Qiong,Jiang, Tao
, p. 1427 - 1435 (2018/02/15)
Although many studies have been focused on the photochemistry of antibiotics, the roles of reactive species in photolysis and the effects of dissolved substances on antibiotic photochemical behavior have been poorly examined. The photolytic behaviors of s
Design, synthesis, and structure-activity relationships of novel imidazo[4,5-c]pyridine derivatives as potent non-nucleoside inhibitors of hepatitis C virus NS5B
Liu, Moyi,Xu, Qiaoling,Guo, Su,Zuo, Ruixi,Hong, Yue,Luo, Yong,Li, Yingxiu,Gong, Ping,Liu, Yajing
, p. 2621 - 2631 (2018/04/30)
The hepatitis C virus (HCV) NS5B polymerase is an attractive target for the development of novel and selective inhibitors of HCV replication. In this paper, the design, synthesis, and preliminary SAR studies of novel inhibitors of HCV NS5B polymerase based on the structure of tegobuvir have been described. The efforts to optimize the antiviral potency and reduce the treatment side effects with respect to genotype 1b resulted in the discovery of compound 3, which exhibited an EC50 of 1.163 nM and a CC50 >200 nM in a cell-based HCV replicon system assay. Additionally, testing for inhibition of the hERG channel showed a marked improvement over tegobuvir and the pharmacokinetic properties of compound 3 indicated that it was worthy of further investigation as a non-nucleoside inhibitor of HCV NS5B polymerase.
Pyrimidine-substituted cinnamyl thiourea compound and application thereof
-
Paragraph 0008; 0021; 0022, (2018/03/26)
The invention discloses a pyrimidine-substituted cinnamyl thiourea compound. The pyrimidine-substituted cinnamyl thiourea compound is shown as a formula I. The compound shown in the formula I is takenas a plant growth regulator. As proved by a wheat seed soaking experiment, the compound shown in the formula I can remarkably increase the wheat germinating rate, and remarkably promote rooting; as proved by an expanding test of cucumber cotyledon, the compound shown in the formula I remarkably promotes cell division, and can effectively regulate and control plant growth. The formula I is shown in the description.
Proton Sensitive Functional Organic Fluorescent Dyes Based on Coumarin-imidazo[1,2-a]pyrimidine; Syntheses, Photophysical Properties, and Investigation of Protonation Ability
Ayd?ner, Burcu,Sefero?lu, Zeynel
, p. 5921 - 5934 (2018/11/23)
A novel series of 2-coumarin-3-yl-imidazo[1,2-a]pyrimidines have been synthesized with functionalized coumarin and pyrimidine units of the different architecture to give various fluorescent compounds. A new additional series bearing unsubstituted coumarin and 7-dialkylaminocoumarin as fluorophore were obtained by palladium-catalyzed cross-coupling reactions, through coupling of 6-bromo-2-coumarin-3-yl-imidazopyrimidine derivatives with various arylboronic acids. In the all reaction step, microwave irradiation (MWI) method was used and compared with the conventional method (CM). Photophysical properties of synthesized compounds were studied by a combination of UV/Vis and fluorescence spectroscopy in various solvents having different polarities. The protonation abilities of all compounds were investigated by titration with trifluoroacetic acid (TFA) in dichloromethane. In both series, the compounds bearing 7-dialkylaminocoumarin are fluorescently active even in daylight and showed maximum absorption wavelengths (λabs–max) in the visible region in all solvents used. In addition, they showed drastic color and emission change in acidic environment. Moreover, for the investigation of protonation ability of three selected compounds bearing 7-dialkylaminocoumarin have been studied using a buffer solution with various pH and determinated their pKa values. The compound bearing morpholine has the potential to use as colorimetric and luminescence pH sensor. The thermal properties of all the synthesized compounds were also evaluated with TGA to test their usability as optic dyes.
