100008-17-1

Basic information

• Product Name: N^α-Boc-L-phenylalanyl-L-prolyl-glycine methyl ester
• Synonyms: N^α-Boc-L-phenylalanyl-L-prolyl-glycine methyl ester
• CAS NO: 100008-17-1
• Molecular Weight: 433.505
• Mol File: 100008-17-1.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: N^α-Boc-L-phenylalanyl-L-prolyl-glycine methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: N^α-Boc-L-phenylalanyl-L-prolyl-glycine methyl ester(100008-17-1)
• EPA Substance Registry System: N^α-Boc-L-phenylalanyl-L-prolyl-glycine methyl ester(100008-17-1)

Safety Data

• Hazardous Substances Data: 100008-17-1(Hazardous Substances Data)

Upstream product

• 33256-35-8 H-Pro-Gly-OMe 
• 13734-34-4 N-tert-butoxycarbonyl-L-phenylalanine 
• 15761-39-4 1-(tert-butoxycarbonyl)-L-proline 
• 34290-72-7 tert-butyloxycarbonyl-prolyl-glycine methyl ester 

Downstream Products

• 100101-21-1 Boc-Tyr-Pro-Phe-Pro-Gly-OMe 
• 77434-41-4 H-Phe-Pro-Gly-OMe 
• 100008-18-2 N^α-Boc-L-Prolyl-L-phenylalanyl-L-prolyl-glycine methyl ester 
• 450407-04-2 Boc-Tyr(t-Bu)-Pro-Phe-Pro-Gly-OMe 
• 77451-91-3 H-Tyr-Pro-Phe-Pro-Gly-OMe 
• 77434-42-5 H-Pro-Phe-Pro-Gly-OMe 
• 72122-63-5 bovine β-casomorphin-5 
• 83280-23-3 β-casomorphine monohydrochloride 

Relevant articles and documents

A rapid and efficient synthesis of β-casomorphin employing Boc-amino acids and 9-fluorenylmethyl chloroformate as a coupling agent

The synthesis of β-casomorphin H-Tyr-Pro-Phe-Pro-Gly-OH employing Boc group for Nα-protection and 9-fluorenylmethyl chloroformate (Fmoc-Cl) for the formation of peptide bond is described. The protocol employing Fmoc-Cl as coupling reagent is found to be simple, efficient and rapid. All the intermediate peptides as well as the final protected peptide Boc-Tyr( iBu)-Pro-Phe-Pro-Gly-OMe have been isolated and fully characterized. They have been obtained in good yield and with high purity.

Optimization of the β-casomorphine-5 synthesis

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