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Cas Database

1000340-35-1

1000340-35-1

Identification

  • Product Name:4-Bromo-1H-pyrrolo[2,3-b]pyridine-3-carbaldehyde

  • CAS Number: 1000340-35-1

  • EINECS:

  • Molecular Weight:225.0421

  • Molecular Formula:C8H5BrN2O

  • HS Code:2933990090

  • Mol File:1000340-35-1.mol

Synonyms:1H-Pyrrolo[2,3-b]pyridine-3-carboxaldehyde, 4-bromo-;

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Safety information and MSDS view more

  • Signal Word:no data available

  • Hazard Statement:no data available

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

  • Fire-fighting measures: Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

Supplier and reference price

  • Manufacture/Brand
  • Product Description
  • Packaging
  • Price
  • Delivery
  • Purchase
  • Manufacture/Brand:Abosyn
  • Product Description:4-Bromo-1H-pyrrolo[2,3-b]pyridine-3-carbaldehyde 95%-98%
  • Packaging:0.25g
  • Price:$ 1080
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:Activate Scientific
  • Product Description:4-Bromo-1H-pyrrolo[2,3-b]pyridine-3-carbaldehyde 95+%
  • Packaging:1 g
  • Price:$ 230
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:AK Scientific
  • Product Description:4-Bromo-1H-pyrrolo[2,3-b]pyridine-3-carbaldehyde
  • Packaging:250mg
  • Price:$ 267
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:Alichem
  • Product Description:4-Bromo-1H-pyrrolo[2,3-b]pyridine-3-carbaldehyde
  • Packaging:5g
  • Price:$ 927
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:Ambeed
  • Product Description:4-Bromo-1H-pyrrolo[2,3-b]pyridine-3-carbaldehyde 96%
  • Packaging:100mg
  • Price:$ 34
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:Ambeed
  • Product Description:4-Bromo-1H-pyrrolo[2,3-b]pyridine-3-carbaldehyde 96%
  • Packaging:250mg
  • Price:$ 68
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:Ambeed
  • Product Description:4-Bromo-1H-pyrrolo[2,3-b]pyridine-3-carbaldehyde 96%
  • Packaging:1g
  • Price:$ 161
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:Apolloscientific
  • Product Description:4-Bromo-1H-pyrrolo[2,3-b]pyridine-3-carbaldehyde
  • Packaging:250mg
  • Price:$ 173
  • Delivery:In stock
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  • Manufacture/Brand:Apolloscientific
  • Product Description:4-Bromo-1H-pyrrolo[2,3-b]pyridine-3-carbaldehyde
  • Packaging:500mg
  • Price:$ 292
  • Delivery:In stock
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  • Manufacture/Brand:Chemenu
  • Product Description:4-bromo-1H-pyrrolo[2,3-b]pyridine-3-carbaldehyde 95%+
  • Packaging:5g
  • Price:$ 842
  • Delivery:In stock
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Relevant articles and documentsAll total 3 Articles be found

PYRROLOPYRIMIDINE ITK INHIBITORS

-

Paragraph 0630; 0631; 0632; 0645; 0646; 0647, (2020/02/27)

Disclosed herein are arylpyridinone compounds and compositions useful in the treatment of ITK mediated diseases, such as inflammation, having the structures of Formulas (I)-(IV): wherein the R groups, m, n, and X are as defined in the detailed description. Methods of inhibition of ITK activity in a human or animal subject are also provided.

3-SUBSTITUTED-1H-PYRROLO[2,3-B]PYRIDINE AND 3-SUBSTITUTED-1H-PYRROLO[3,2-B]PYRIDINE COMPOUNDS, THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESES

-

Page/Page column 36-37, (2009/12/23)

The invention relates to 3-substituted-1H-pyrrolo[2,3-b]pyridine, and 3-substituted-1H-pyrrolo[3,2-b]pyridine compounds of the Formula 1: or a pharmaceutically acceptable salt thereof, wherein the constituent variables are as defined herein, compositions comprising the compounds, and methods for making and using the compounds.

3-SUBSTITUTED-1H-INDOLE, 3-SUBSTITUTED-1H-PYRROLO[2,3-B]PYRIDINE AND 3-SUBSTITUTED-1H-PYRROLO[3,2-B]PYRIDINE COMPOUNDS, THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESES

-

Page/Page column 120, (2010/04/06)

The invention relates to 3-substituted-1H-indole, 3-substituted-1H-pyrrolo[2,3-b]pyridine, and 3-substituted-1H-pyrrolo[3,2-b]pyridine compounds of the Formula (I): or a pharmaceutically acceptable salt thereof, wherein the constituent variables are as defined herein, compositions comprising the compounds, and methods for making and using the compounds.

Process route upstream and downstream products

Process route

hexamethylenetetramine
100-97-0

hexamethylenetetramine

4-bromo-7-azaindole
348640-06-2

4-bromo-7-azaindole

4-bromo-1H-pyrrolo[2,3-b]pyridine-3-carboxaldehyde
1000340-35-1

4-bromo-1H-pyrrolo[2,3-b]pyridine-3-carboxaldehyde

Conditions
ConditionsYield
With acetic acid;Inwater;at 100 ℃; for 16h;
86%
1-(4-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)-N,N-dimethylmethanamine
1198277-82-5

1-(4-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)-N,N-dimethylmethanamine

hexamethylenetetramine
100-97-0

hexamethylenetetramine

4-bromo-1H-pyrrolo[2,3-b]pyridine-3-carboxaldehyde
1000340-35-1

4-bromo-1H-pyrrolo[2,3-b]pyridine-3-carboxaldehyde

Conditions
ConditionsYield
With propionic acid; at 120 ℃; Reflux;
79%
With propionic acid; at 120 ℃; Reflux;
79%
hexamethylenetetramine
100-97-0

hexamethylenetetramine

4-bromo-7-azaindole
348640-06-2

4-bromo-7-azaindole

4-bromo-1H-pyrrolo[2,3-b]pyridine-3-carboxaldehyde
1000340-35-1

4-bromo-1H-pyrrolo[2,3-b]pyridine-3-carboxaldehyde

Conditions
ConditionsYield
With acetic acid;Inwater;at 100 ℃; for 16h;
86%
1-(4-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)-N,N-dimethylmethanamine
1198277-82-5

1-(4-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)-N,N-dimethylmethanamine

hexamethylenetetramine
100-97-0

hexamethylenetetramine

4-bromo-1H-pyrrolo[2,3-b]pyridine-3-carboxaldehyde
1000340-35-1

4-bromo-1H-pyrrolo[2,3-b]pyridine-3-carboxaldehyde

Conditions
ConditionsYield
With propionic acid; at 120 ℃; Reflux;
79%
With propionic acid; at 120 ℃; Reflux;
79%

Global suppliers and manufacturers

Global( 28) Suppliers
  • Company Name
  • Business Type
  • Contact Tel
  • Emails
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  • Amadis Chemical Co., Ltd.
  • Business Type:Lab/Research institutions
  • Contact Tel:86-571-89925085
  • Emails:sales@amadischem.com
  • Main Products:29
  • Country:China (Mainland)
  • Finetech Industry Limited
  • Business Type:Trading Company
  • Contact Tel:86-27-87465837
  • Emails:sales@finetechnology-ind.com
  • Main Products:29
  • Country:China (Mainland)
  • Antimex Chemical Limied
  • Business Type:Lab/Research institutions
  • Contact Tel:0086-21-50563169
  • Emails:anthony@antimex.com
  • Main Products:151
  • Country:China (Mainland)
  • SAGECHEM LIMITED
  • Business Type:Lab/Research institutions
  • Contact Tel:+86-571-86818502
  • Emails:will@sagechem.com
  • Main Products:28
  • Country:China (Mainland)
  • Debye Scientific
  • Business Type:Lab/Research institutions
  • Contact Tel:+85221376140
  • Emails:sales@debyesci.com
  • Main Products:13
  • Country:China (Mainland)
  • Bide Pharmatech Ltd
  • Business Type:Other
  • Contact Tel:021-61629020
  • Emails:sales@bidepharmatech.com
  • Main Products:1
  • Country:China (Mainland)
  • Shanghai Sunway Co. Ltd.
  • Business Type:Trading Company
  • Contact Tel:86-13262956501
  • Emails:celia_sunway@163.com
  • Main Products:1
  • Country:China (Mainland)
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