1000870-48-3Relevant articles and documents
Targeted pH-dependent fluorescent activity-based cathepsin probes
Hoogendoorn, Sascha,Habets, Kim L.,Passemard, Solene,Kuiper, Johan,Van Der Marel, Gijsbert A.,Florea, Bogdan I.,Overkleeft, Herman S.
, p. 9363 - 9365 (2011/10/03)
Bifunctional, pH-activatable BODIPY dyes were developed and incorporated in mannose cluster-containing activity-based probes for cysteine proteases. Mannose receptor-dependent uptake of the probes in dendritic cells, followed by trafficking to acidic cellular compartments resulted in fluorescence as seen by live-cell imaging, and subsequent cathepsin inhibition.