bis-carboxylic acid (1,3,5,7-tetramethyl-2,6-bis(2-carboxyethyl)-8-(p-diethylaminophenyl)-4,4-difluoro-4-bora-3a,4a-diaza-s-indacene)

Base Information

• Chemical Name: bis-carboxylic acid (1,3,5,7-tetramethyl-2,6-bis(2-carboxyethyl)-8-(p-diethylaminophenyl)-4,4-difluoro-4-bora-3a,4a-diaza-s-indacene)
• CAS No.: 1000870-48-3
• Molecular Formula: C₂₉H₃₆BF₂N₃O₄
• Molecular Weight: 539.43
• Mol file: 1000870-48-3.mol

Synonyms:bis-carboxylic acid (1,3,5,7-tetramethyl-2,6-bis(2-carboxyethyl)-8-(p-diethylaminophenyl)-4,4-difluoro-4-bora-3a,4a-diaza-s-indacene)

Chemical Property of bis-carboxylic acid (1,3,5,7-tetramethyl-2,6-bis(2-carboxyethyl)-8-(p-diethylaminophenyl)-4,4-difluoro-4-bora-3a,4a-diaza-s-indacene)

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of bis-carboxylic acid (1,3,5,7-tetramethyl-2,6-bis(2-carboxyethyl)-8-(p-diethylaminophenyl)-4,4-difluoro-4-bora-3a,4a-diaza-s-indacene)

There total 3 articles about bis-carboxylic acid (1,3,5,7-tetramethyl-2,6-bis(2-carboxyethyl)-8-(p-diethylaminophenyl)-4,4-difluoro-4-bora-3a,4a-diaza-s-indacene) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

1,3,5,7-tetramethyl-2,6-bis(2-methoxycarbonylethyl)-8-[4-(N,N-diethylamino)phenyl]-4,4-difluoro-4-bora-3a,4a-diaza-s-indacene (1000870-47-2) → bis-carboxylic acid (1,3,5,7-tetramethyl-2,6-bis(2-carboxyethyl)-8-(p-diethylaminophenyl)-4,4-difluoro-4-bora-3a,4a-diaza-s-indacene) (1000870-48-3)

Guidance literature:

1,3,5,7-tetramethyl-2,6-bis(2-methoxycarbonylethyl)-8-[4-(N,N-diethylamino)phenyl]-4,4-difluoro-4-bora-3a,4a-diaza-s-indacene; With sodium hydroxide; water; In methanol; dichloromethane; acetone; at 20 ℃; for 4h;

With hydrogenchloride; In methanol; dichloromethane; water; UV-irradiation;

Reference yield:

methyl 2,4-dimethyl-3-pyrrolepropionate (54474-51-0) → bis-carboxylic acid (1,3,5,7-tetramethyl-2,6-bis(2-carboxyethyl)-8-(p-diethylaminophenyl)-4,4-difluoro-4-bora-3a,4a-diaza-s-indacene) (1000870-48-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: trifluoroacetic acid / dichloromethane / 20 °C / Inert atmosphere

1.2: 1 h / 20 °C / Inert atmosphere

1.3: 0.67 h / Reflux; Inert atmosphere

2.1: sodium hydroxide / 1,4-dioxane; methanol; water / 1 h / 40 °C

With trifluoroacetic acid; sodium hydroxide; In 1,4-dioxane; methanol; dichloromethane; water;

DOI:10.1039/c1cc12947c

Reference yield:

4-Diethylaminobenzaldehyde (120-21-8) → bis-carboxylic acid (1,3,5,7-tetramethyl-2,6-bis(2-carboxyethyl)-8-(p-diethylaminophenyl)-4,4-difluoro-4-bora-3a,4a-diaza-s-indacene) (1000870-48-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: trifluoroacetic acid / dichloromethane / 20 °C / Inert atmosphere

1.2: 1 h / 20 °C / Inert atmosphere

1.3: 0.67 h / Reflux; Inert atmosphere

2.1: sodium hydroxide / 1,4-dioxane; methanol; water / 1 h / 40 °C

With trifluoroacetic acid; sodium hydroxide; In 1,4-dioxane; methanol; dichloromethane; water;

DOI:10.1039/c1cc12947c

upstream raw materials:

1,3,5,7-tetramethyl-2,6-bis(2-methoxycarbonylethyl)-8-[4-(N,N-diethylamino)phenyl]-4,4-difluoro-4-bora-3a,4a-diaza-s-indacene

4-Diethylaminobenzaldehyde

methyl 2,4-dimethyl-3-pyrrolepropionate

Downstream raw materials:

1,3,5,7-tetramethyl-2-(2-carboxyethyl)-6-(2-succinimidyloxycarbonylethyl)-8-[4-(N,N-diethylamino)-phenyl]-4,4-difluoro-4-bora-3a,4a-diaza-s-indacene

C₄₁H₅₅BF₂N₈O₈

Refernces

• 1、 -. "PH-SENSITIVE FLUORESCENT PROBE". Page/Page column 5; 8. . Retrieved 2009/09/26.