10019-06-4Relevant articles and documents
Phenylimino-10H-anthracen-9-ones as novel antimicrotubule agents - Synthesis, antiproliferative activity and inhibition of tubulin polymerization
Prinz, Helge,Schmidt, Peter,Boehm, Konrad J.,Baasner, Silke,Mueller, Klaus,Gerlach, Matthias,Guenther, Eckhard G.,Unger, Eberhard
experimental part, p. 4183 - 4191 (2011/08/09)
A novel series of phenylimino-10H-anthracen-9-ones and 9-(phenylhydrazone)- 9,10-anthracenediones were synthesized and evaluated for interaction with tubulin and for cytotoxicity against a panel of human tumor cell lines. The 10-(3-hydroxy-4-methoxy-pheny
Syntheses and Reactions of Spiroanthronetriazolines
Hirakawa, Kiyoichi,Ito, Tsutomu,Okubo, Yoshiji,Nakazawa, Sho
, p. 1668 - 1672 (2007/10/02)
Quinone methide 1a reacts with aryl azides 2 to give the corresponding spiroanthronetriazolines 3 along with byproducts, collected in Table I, which are formed by the thermal reaction of 3 or 1a.Quinone methide 1b adds to azides 2 to give spiroanthronetriazolines 5 or their subsequent products.Pyrolysis of 3 regenerates the starting quinone methide 1a and azide 2, and their photolysis leads to 1a.Pyrolysis and photolysis of 5 yield aryliminoanthrone 7, arylaminodibenzocycloheptenone 12, or its isomer 19.Attempts to convert 3 and 5 into spiroanthroneaziridines 14 and 15, respectively, were unsuccessful.Reactions of 3 and 5 with acid catalysts give the rearrangement products dibenzocycloheptenediones 23 and 24, respectively, in high yields.These reactions are discussed in mechanistic terms.
