1002-40-0Relevant articles and documents
Conjugated 5-fluorouracil with mitochondria-targeting lipophilic cation: Design, synthesis and biological evaluation
Wang, Jia,Fan, Xiao-Yang,Yang, Li-Yun,He, Huan,Huang, Rong,Jiang, Feng-Lei,Liu, Yi
, p. 2016 - 2019 (2016)
5-Fluorouracil (5-FU) was linked with F16 by vulnerable bonds to selectively target cancer mitochondria which resulted in conjugated compounds, including F16-5-FU, F16-OOC-FU, F16-NHOC-FU and F16-SS-FU. F16-OOC-FU decreased the antiproliferative activity of 5-FU on the nontumor cell line, and the cytotoxicity of F16-SS-FU significantly increased when administered with dithiothreitol (DTT).
Gas chromatography/mass spectrometry analysis of reaction products of sulfur mustards with phenol
Prabhakar, S.,Reddy, T Jagadeshwar,Sandeep, M.,Srinivas, K.,Suresh Pal, A.,Veeresham, A.
, p. 213 - 224 (2019/11/22)
Screening of chemicals related to chemical weapons convention including their all possible degradation and reaction products in environmental samples is important in the organization for prohibition of chemical weapons verification process. Sulfur mustards, commonly known as blistering agents, are included in schedule 1 chemicals of chemical weapons convention. Because of the presence of chlorine atoms in sulfur mustards, they are highly reactive and prone to react with other organic molecules such as phenols to produce corresponding reaction products. Thus, it is important to screen for not only the sulfur mustards but also their reaction products for verification process. The sulfur mustards and their degradation products have been routinely analyzed by gas chromatography/mass spectrometry method, however, the methods are yet to establish for the reaction products. In this study, the reaction products of the sulfur mustards with phenol (compounds 1–7) were studied by gas chromatography/mass spectrometry under electron ionization and chemical ionization conditions. The EI spectra of 1–7 displayed molecular ion and characteristic fragments that provided structure information. Mostly the fragment ions were due to homolytic cleavages involving C–O, C–S, and C–C cleavages. The methane or isobutane CI spectra showed M+., [M + H]+, and [M ? H]+ ions including reagent specific adduct ions. The CI spectra also showed other adduct ions formed by association of analyte molecule with its most abundant fragment ion. The gas chromatography/retention index values were also calculated, which support unambiguous identification of targeted molecules in suspected environmental samples. The method was demonstrated for detection of the targeted molecules spiked in soil samples.
Preparation method of high-purity mesna
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Paragraph 0037; 0038; 0039; 0046; 0052, (2017/10/22)
The invention belongs to the technical field of drug synthesis, and particularly relates to a preparation method of high-purity mesna. The invention provides a brand new synthetic thought of high-purity mesna. Since a sulfydryl compound is unstable, and a disulfide bond is likely to form, a main impurity (di-mesna) of mesna is firstly prepared, and finally the di-mesna is decomposed into mesna by virtue of conventional hydrogenation reduction, so that the process flow greatly reduces the content of the di-mesna in the mesna, the reaction raw materials are easy to obtain, the operation is simple, the yield and purity are greatly increased, and the preparation method is suitable for the industrialized production.
Nanoparticles and nanoparticle compositions
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Page/Page column 54, (2016/06/01)
The invention provides multivalent surface-crosslinked micelle (SCM) particles, crosslinked reverse micelle (CRM) particles, and methods of making and using them. The SCM particles can be used, for example, to inhibit a virus or bacteria from binding to a host cell. The inhibition can be used in therapy for the flu, cancer, or AIDS. The CRM particles can be used, for example, to prepare metal nanoparticles or metal alloy nanoparticles, or they can be used in catalytic reactions.