1003567-30-3

Basic information

• Product Name: spiro[benzofuran-2(3H),4'-piperidine], 5-chloro-, hydrobroMide (1: 1)
• Synonyms: spiro[benzofuran-2(3H),4'-piperidine], 5-chloro-, hydrobroMide (1: 1)
• CAS NO: 1003567-30-3
• Molecular Formula: BrH*C₁₂H₁₄ClNO
• Molecular Weight: 304.6106
• Mol File: 1003567-30-3.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: spiro[benzofuran-2(3H),4'-piperidine], 5-chloro-, hydrobroMide (1: 1)(CAS DataBase Reference)
• NIST Chemistry Reference: spiro[benzofuran-2(3H),4'-piperidine], 5-chloro-, hydrobroMide (1: 1)(1003567-30-3)
• EPA Substance Registry System: spiro[benzofuran-2(3H),4'-piperidine], 5-chloro-, hydrobroMide (1: 1)(1003567-30-3)

Safety Data

• Hazardous Substances Data: 1003567-30-3(Hazardous Substances Data)

Upstream product

• 1003567-08-5 4-(5-chloro-2-methoxy-benzyl)-4-hydroxy-piperidine-1-carboxylic acid tert-butyl ester 

Downstream Products

• 71916-97-7 5-chloro-2,3-dihydrospiro 
• 1003567-11-0 5-chloro-2-{[(2S)-3-(5-chloro-3H-spiro[1-benzofuran-2,4'-piperidin]-1'-yl)-2-hydroxypropyl]oxy}-4-(p-methoxybenzyloxy)-N-methylbenzamide 
• 1003567-17-6 2-{2-chloro-5-{[(2S)-3-(5-chloro-3H-spiro[1-benzofuran-2,4'-piperidin]-1'-yl)-2-hydroxypropyl]oxy}-4-[(methylamino)carbonyl]phenoxy}-2-methylpropanoic acid tert-butyl ester 

Relevant articles and documents

SPLROPIPERIDINE COMPOUNDS, A PROCESS OF THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND THEIR USE IN THE TREATMENT OF AIRWAY DISEASES, INFLAMMATORY DISEASES, COPD OR ASTHMA

The present invention relates to new polymorphs of compounds 2-{2-Chloro-5-{[(2S)-3-(5-chloro-1'H,3H-spiro[1-benzofuran-2,4'-piperidin]-1'-yl)-2-hydroxypropyl]oxy}-4- [(methylamino)carbonyl]phenoxy}-2-methylpropanoic acid, and the hydrochloride and sodium hydroxide salts thereof,and compound 2-{2-Chloro-5-{[(2R)-3-(5-chloro-1'H,3H-spiro[1-benzofuran-2,4'-piperidin]-1'-yl)-2-hydroxypropyl]oxy}-4- [(methylamino)carbonyl]phenoxy}-2-methylpropanoic acid. The invention further relates to pharmaceutical composition containing said compounds and to the use of said compounds in therapy. The present invention also relates to processes for the preparation of said compounds.

NOVEL TRICYCLIC SPIROPIPERIDINE COMPOUNDS, THEIR SYNTHESIS AND THEIR USES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY

Compounds of formula (I) wherein R1, R3, R4, R5, R6, R7, and R10 are as defined in the specification, are described. The present invention also relates to pharmaceutical composition comprising said compounds and to the use of said compounds in therapy. The present invention further relates to processes for the preparation of said compounds and to new intermediates useful in the preparation thereof. Beside, the invention relates to salts and polymorphic forms of the new compounds as well as the preparation thereof.