100752-52-1

Basic information

• Product Name: 5-isopropyl-2-methylphenyl benzoate
• Synonyms: 5-isopropyl-2-methylphenyl benzoate
• CAS NO: 100752-52-1
• Molecular Formula: C₁₇H₁₈O₂
• Molecular Weight: 254.32362
• Mol File: 100752-52-1.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5-isopropyl-2-methylphenyl benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: 5-isopropyl-2-methylphenyl benzoate(100752-52-1)
• EPA Substance Registry System: 5-isopropyl-2-methylphenyl benzoate(100752-52-1)

Safety Data

• Hazardous Substances Data: 100752-52-1(Hazardous Substances Data)

Upstream product

• 499-75-2 carvacrol 
• 98-88-4 benzoyl chloride 

Relevant articles and documents

Synthesis of biologically active carvacrol compounds using different solvents and supports

Natural monoterpenoids have been documented for their acute toxicity and repellent, antifeedent, reproduction inhibitory, and insecticidal actions. The present work aims to derive a variety of ether and ester compounds using polymer-supported reactions from the polymer-supported carvacrol anion was reacted with alkyl halides and acid chlorides to afford carvacryl ethers and esters, respectively. Furthermore, a special study on the effect of different solvents and supports revealed that Amberlite IRA 400 (chloride form) was found to be the best polymer support and acetone among the solvents. Copyright Taylor & Francis Group, LLC.

Synthesis and in vitro antibacterial activity of thymol and carvacrol derivatives

Fourteen esters of thymol and carvacrol were synthesized and characterized on the basis of spectral data. The NMR data for some of these are being given for the first time. The antibacterial activity screening of thymol, carvacrol and their esters were carried out against four Gram-positive (Streptococcus mutans MTCC 890, Staphylococcus aureus MTCC 96, Bacillus subtilis MTCC 121, Staphylococcus epidermidis MTCC 435) and one Gram-negative (Escherichia coli MTCC 723) bacteria. The enhancement in activity was noticed in the thymyl ester derivatives 4a-c (against S. mutans, B. subtilis and S. epidermidis) in comparison to thymol, whereas the carvacrol derivatives were found to be much less active than carvacrol.

Solid-supported synthesis of bio-active carvacrol compounds using microwaves

The most abundant and potent natural products having a broad spectrum of biological activity against various pests are terpenoids, especially monoterpenoids. The chemical modification of natural monoterpenoids has been reported to result in modified biological activity. The present work emphasizes the structural modification of carvacrol, a phenolic monoterpenoid, through the synthesis of different ether and ester derivatives that are useful for structure-activity relationship studies to exploit the potent molecules. The carvacrol was reacted with alkyl halides and acid chlorides under microwaves using solid supports such as silica gel, alumina, and fly ash to give ethers and esters, respectively. The synthesis of dimeric ether and ester compounds using dihalides and acid dichlorides was conducted with novel reactions. Additional features of the methodology include very fast reactions, higher yields and purities of the products, and an ecofriendly approach. Copyright Taylor & Francis Group, LLC.

Cl3CCONH2/PPh3: A versatile reagent for synthesis of esters

Cl3CCONH2/PPh3 was a versatile reagent to convert carboxylic acids into their corresponding acid chlorides. This intermediate was clearly confirmed by spectroscopic methods (IR, 1H, 13C NMR). This one-pot reaction of in situ acid chloride generated with various alcohols successfully furnished the corresponding esters in moderate to excellent yields. Copyright ? Taylor & Francis Group, LLC.