499-75-2 Usage
Artificial flavor
Carvacrol is the isomeric body of thymol with similar aroma as thymol. Carvacrol naturally exists in thyme oil and other essential oils, having especially high content in the thyme oil produced in Spain.
Carvacrol is mainly used in the preparation of dill, girofle, mint and vanilla flavor to be used for toothpaste, toothpaste powder, oral products, talcum powder, soap and daily industrial products. In medicine, it is used for local anesthetics. In addition, carvacrol is capable of killing bacteria and intestinal parasites and can be used as disinfectants and fungicides. According to the information reported, the acute toxicity data of carvacrol: oral LD50810mg/kg (rat), skin test: LD50> 5g/kg (rabbit).
Thyme plant has its origin including the Northeast, Hebei, and Inner Mongolia, Gansu, Qinghai and Xinjiang and other provinces. Ingredients: whole plant of thyme contains about 0.15~0.5% volatile oil (in oil, the component mainly contains carvacrol, paraffin, thymol), amaroid and tannin. Leaves contain free oleanolic acid, ursolic acid, caffeic acid and so on. Thyme can be not only used in medicine, for spices, but also be as the superior natural health ingredients of the processed foods. Since the 1980s, thyme-like herbal foods have become very popular. Studies have shown that thyme-containing volatile oils, in addition to being used as seasoning and for treatment of illnesses, also have anti-corrosion, antibacterial and other functions. Therefore, the consumers can benefit a lot using it as food raw materials. Because of this, in Europe, natural herbal tea also contains thyme. For example, a kind of herb tea raw material having anti-cough effect and being able to prevent and treat bronchitis has 10% thyme leaves.
Image 1: Thymus plant
Chemical properties
Different sources of media describe the Chemical properties of 499-75-2 differently. You can refer to the following data:
1. Use sulfuric acid to sulfonate the p-isopropyl toluene, generating p-isopropyl toluene-2-sulfonic acid. Then we can obtain carvacrol after alkali melting treatment.
Image 2: Preparation of carvacrol from p-isopropyltoluene
Carvacrol, when co-melted together with potassium hydroxide, can give 2-hydroxy-4-isopropyl benzoic acid while reaction with phosphorus pentachloride can generate 2-chloro-1-methyl-4-isopropyl benzene. In acetic acid, it reaction with 1 mol Bromine can generate 4-bromocarbinol while its reaction with 2 mol bromine can generate 4, 6-dibromo carvacrol; if reacted with bromine and aluminum, we can obtain tetrabromo-o-cresol. It is easily soluble in concentrated sulfuric acid to produce 2-methyl-5-isopropyl phenol-4-sulfonic acid. In aqueous sodium hydroxide solution, it can be reacted with formaldehyde to generate carvacrol phenols alcohol:
Image 3: The reaction between carvacrol and formaldehyde for generation of carvacrol phenolic alcohol
It exhibits green color when reacted with ferric chloride in ethanol with no significant color in the water.
2. It appears as colorless to pale yellow slightly viscous oil. When placed in air and light, its color becomes darker. It has spicy, cool incense, herbs incense with thymol-like smell. It has a boiling point of 238 ° C, the melting point of 0.5 to 1 ° C and the flash point of 100 ° C. It is soluble ethanol, ethyl ether, propylene glycol and alkali, do not dissolve in water. It is miscible in oil.
The natural products are found in thyme oil (about 70%), oregano oil (about 80%) and mange to oil and so on.
Content analysis
It can be determined by the non-polar column method by GT-10-4.
Toxicity
GRAS (FEMA).
LD50: 810 mg/kg (rat, oral).
Usage limit
FEMA (mg/kg): soft drinks 26; cold drinks 34; candy 92; baked goods 120; condiments 37.
Take appropriate as limit (FDA § 172.515, 2000).
Allow to use (GB 2760-1996).
Standard for Maximum Allowable Amount
▼▲
Name of additive
Field allowed to use it as additive
Function of additive
Maximal allowable amount（g/kg）
arvacrol
Food
Food spices
The perfume ingredients used in formulating fragrances shall not exceed the maximum allowable documented amount in GB 2760
Application
Spices; It is mainly used for the preparation of dill, girofle, meat, peppermint, vanilla flavor and so on.
It can be used for the preparation of spices, fungicides and disinfectants. As a spice, it can be used in toothpaste, soap and other daily necessities, but also for food flavors.
It can be used for spices, food additives, feed additives, antioxidants, sanitation fungicide, insect repellent, preservatives, deodorant and pharmaceutical intermediates.
Preparation
Different sources of media describe the Preparation of 499-75-2 differently. You can refer to the following data:
1. It can be obtained through treatment of the essential oil containing rich content of natural carvacrol followed by ether extraction or steam distillation to derive it.
It can be derived by the sulfonation of thymol followed by alkali treatment.
2. From p-cymene by sulfonation and subsequent alkali fusion.
Category
Pesticides
Toxic classification
middle-level poisoning
Acute toxicity
Oral-rat LD50: 810 mg/kg; intravenous-mouse LD50: 80 mg/kg
Stimulation Data Skin-Rabbit 500 mg/24 h Severe
Flammability and Hazardous characteristics
It is flammable upon heat, fire and strong oxidants with thermal decomposition releasing spicy stimulated smoke
Storage and transportation characteristics
Treasury: low temperature, ventilated and dry; avoid fire and high temperature; store it separately from oxidant.
Extinguishing agent
fog, carbon dioxide, foam, dry powder
Chemical Properties
Different sources of media describe the Chemical Properties of 499-75-2 differently. You can refer to the following data:
1. liquid
2. Carvacrol has a characteristic pungent, warm odor. The commercial product consists of a mixture of isomers differing
because of the position of the isopropyl radical. The odor characteristics differ between the technical (lower grade) and pure (higher
grade) commercial products.
Occurrence
Reported found in cumin seed, thyme, oregano, calamus, lovage, myrtle and lemon balm.
Uses
Different sources of media describe the Uses of 499-75-2 differently. You can refer to the following data:
1. Reference Standard in the analysis of herbal medicinal products
2. Carvacrol is a flavoring agent that is a colorless to pale yellow liquid.
it has a spicy and pungent odor, resembling thymol. it is insoluble in
water and soluble in alcohol and ether. it is a mixture of the isomeric
carvacrols (isopropyl o-creols), and is obtained by chemical synthesis.
it is also an ingredient of savory, a fragrant herb in nature.
3. As disinfectant; in organic syntheses.
Definition
ChEBI: A phenol that is a natural monoterpene derivative of cymene. An inhibitor of bacterial growth, it is used as a food additive. Potent activator of the human ion channels transient receptor potential V3 (TRPV3) and A1 (TRPA1).
Aroma threshold values
Detection at 2.29 ppm.
Taste threshold values
Taste characteristics at 5.0 ppm: spicy, herbal phenolic, medicinal and woody.
General Description
Produced and qualified by HWI pharma services GmbH.Exact content by quantitative NMR can be found on the certificate.
Flammability and Explosibility
Notclassified
Safety Profile
Poison by ingestion,
intravenous, and subcutaneous routes.
Moderately toxic by skin contact. A severe
skin irritant. Combustible liquid. When
heated to decomposition it emits acrid
smoke and irritating fumes.
Check Digit Verification of cas no
The CAS Registry Mumber 499-75-2 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 4,9 and 9 respectively; the second part has 2 digits, 7 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 499-75:
(5*4)+(4*9)+(3*9)+(2*7)+(1*5)=102
102 % 10 = 2
So 499-75-2 is a valid CAS Registry Number.
InChI:InChI=1/C10H14O/c1-7(2)9-5-4-8(3)10(11)6-9/h4-7,11H,1-3H3
499-75-2Relevant articles and documents
-
Wolinsky,J.,Hutchins,R.O.
, p. 3294 - 3299 (1972)
-
The chemistry of thujone. XIX. 1 Acid-promoted ring cleavage of thujone-derived cyclopropylcarbinols
Kutney, James P.,Chen, Yong-Huang,Rettig, Steven J.
, p. 1753 - 1761 (1996)
Thujone-derived cyclopropylcarbinols can cleave via three distinct pathways: the exo cleavage, the endo cleavage, and the interesting cyclopropylcarbinyl rearrangement. Factors determining which pathway is adopted under specific conditions are discussed. A short sequence leading to synthesis of the sesquiterpene (+)-β-cyperone is described.
Strubell,Baumgaertel
, p. 66 (1958)
3'-KETOGLYCOSIDE COMPOUND FOR THE SLOW RELEASE OF A VOLATILE ALCOHOL
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Page/Page column 61-62, (2021/08/20)
The present invention relates to a 3'-ketoglycoside compound defined by formula (I) and its use for controlled release of alcohols, in particular alcohols showing an insect repellent effect. It relates also to a process for preparing the 3'-ketoglycoside compound of formula (I). It further relates to a composition comprising a 3'- ketoglycoside compound of formula (I). It relates also to the use of a 3'-ketoglycoside compound of formula (I) for the controlled release of alcohols. It related also to a method of use of such composition.
Method for synthesizing carvacrol from 8-hydroxycarvone
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Paragraph 0005; 0015-0026, (2021/03/13)
The invention discloses a method for synthesizing carvacrol from 8-hydroxy carvone, which comprises the following steps: dissolving the raw material 8-hydroxy carvone and a catalyst in a solvent, heating to perform dehydration and rearrangement reaction on the 8-hydroxy carvone to generate carvacrol, performing filtering to separate the catalyst after the reaction is finished, rectifying the filtrate under reduced pressure, and recycling the solvent; and further decompressing and rectifying to obtain a carvacrol finished product. The catalyst is a strong acid or weak acid cationic resin catalyst. According to the brand-new carvacrol synthesis method provided by the invention, the existing 8-hydroxy carvone is comprehensively utilized, the application range of the 8-hydroxy carvone is expanded, and the production cost of carvacrol is reduced; the method is mild in reaction condition, easy and convenient to operate and high in reaction efficiency, the product yield can reach 98%, and themethod has good industrial application prospects.
