101-05-3Relevant articles and documents
Design, synthesis, and cytotoxicity of novel 2,4,6-trisubstituted 1,3,5-triazines bearing aryl hydrazone moiety as potent antitumor agent
Wang, Limei,Zhao, Sijia,Bao, Guanglong,Zhang, Yu,Xi, Shuancheng,Zhou, Guolin,Zhai, Xin,Gong, Ping
, p. 621 - 630 (2016/10/18)
A novel series of 2,4,6-trisubstituted 1,3,5-triazine derivatives bearing aryl hydrazone moiety were designed and synthesized under the guidance of scaffold hopping and bioisosterism from the autophagy inhibitor VLX600. The target compounds were evaluated for cytotoxicity against HT-29 by MTT assay with VLX600 as positive control. Then, ten potent target compounds (5c-5f, 5i-5r, 5s, 5t) were further evaluated against two cancer cell lines H460 and A549 and one normal cell line WI-38. Most of them exhibited significant cytotoxicity against one or more cell lines. Particularly, a promising compound 5f was identified, which exhibited the most potent cytotoxicity against HT-29, H460 and A549 cancer cell lines with IC50 values of 0.047 μM, 0.071 μM and 0.071 μM, respectively, which was 10-to 62-folds more potent than VLX600 (IC50 = 0.47 μM, 4.1 μM, 4.4 μM). The preliminary structure-activity relationships (SARs) of the compounds were also discussed.
HEXAHYDROTRIAZINES, SYNTHESIS AND USE
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Page/Page column, (2013/05/22)
Methods for making asymmetrical triazines are provided. The methods comprise first forming a mixture of at least two primary amines then reacting the mixture with an aldehyde. Methods for removing sulfides from hydrocarbon streams are also provided. The triazines may be added to the hydrocarbon stream in a molar ratio of triazine:H2S of about 10:1 to about 1:2.
Targeting the hydrophobic region of Hsp90's ATP binding pocket with novel 1,3,5-triazines
Lee, Taeho,Seo, Young Ho
supporting information, p. 6427 - 6431 (2013/11/19)
Heat shock protein 90 (Hsp90) is a molecular chaperone that plays an important role in regulating the maturation and stabilization of many oncogenic proteins. In an attempt to discover a new class of Hsp90 inhibitors, a series of 1,3,5-triazine compounds were rationally designed, synthesized, and their biological activities were evaluated. Compound 3b was found to degrade Hsp90's client proteins of Her2, Met and Akt and to induce the expression level of Hsp70. The binding mode of 3b in the ATP-binding site of Hsp90 was predicted by the molecular docking.
Dyes and their use in ink-jet printing
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, (2008/12/07)
A compound of Formula (1) or a salt thereof: wherein: A is optionally substituted aryl or optionally substituted heterocyclyl; and R1 and R2 are independently H or a substituent. Also metal chelates, compositions, inks, printing processes, printed material and ink-jet cartridges.
N4-Phenyl modifications of N2-(2-hydroxyl)ethyl-6-(pyrrolidin-1-yl)-1,3,5-triazine-2,4-d iamines enhance glucocerebrosidase inhibition by small molecules with potential as chemical chaperones for Gaucher disease
Huang, Wenwei,Zheng, Wei,Urban, Daniel J.,Inglese, James,Sidransky, Ellen,Austin, Christopher P.,Thomas, Craig J.
, p. 5783 - 5789 (2008/02/13)
A series of 1,3,5-triazine-2,4,6-triamines were prepared and analyzed as inhibitors of glucocerebrosidase. Synthesis, structure activity relationships and the selectivity of chosen analogues against related sugar hydrolases enzymes are described.
Photochemical Crosslinkers for Polymer Coatings and Substrate Tie-Layer
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, (2008/06/13)
The invention describes novel crosslinking compounds that include photoactivatable moieties. Several families of compounds are disclosed that can include one or more hydrophilic moieties that help to solubilize the compounds in aqueous environments.
Triazine library with linkers
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, (2008/06/13)
Triazine linkers can be used as universal small molecule chips for functional proteomics and sensors. These compounds are prepared by making a first building block by adding a first amine by reductive amination of triazine, making a second building block by adding a second amine to cyanuric chloride, and combining the first and second building blocks by aminating the first building block onto one of the chloride positions of the second building block.
Inhibitors of protein kinase for the treatment of disease
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, (2008/06/13)
The present invention is directed in part towards methods of modulating the function of protein kinases with phenol- and hydroxynaphthalene-based compounds. The methods incorporate cells that express a protein kinase. In addition, the invention describes methods of preventing and treating protein kinase-related abnormal conditions in organisms with a compound identified by the invention. Furthermore, the invention pertains to phenol- and hydroxynaphthalene-based compounds and pharmaceutical compositions comprising these compounds.
Organic electroluminescent (EL) devices
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, (2008/06/13)
A new class of conjugated organic polymers or copolymers comprising a triazine group. This class of polymers or copolymers may be used in organic electroluminescent (EL) devices.
Sodium channel drugs and uses
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, (2008/06/13)
The compounds of this invention comprise 2-10 ligands covalently connected, each of the ligands being capable of binding to a ligand binding site in a Na+channel, thereby modulating the biological activities thereof.