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(S)-Boc-γ-Iodo-Abu-OMe is a chemical compound derived from the natural amino acid methionine, featuring a Boc (tert-butyloxycarbonyl) protecting group at the N-terminus and an OMe (methoxy) group at the C-terminus. The γ-Iodo-Abu (γ-iodo-aminobutyric acid) moiety in its structure provides a reactive site for further functionalization, making it a versatile building block in organic synthesis, particularly in peptide and small molecule synthesis. Its unique structure allows for the introduction of a wide variety of functional groups through subsequent reactions, which is highly valuable in the field of medicinal chemistry and drug discovery for creating new compounds with potential biological activities.

101650-14-0

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101650-14-0 Usage

Uses

Used in Medicinal Chemistry:
(S)-Boc-γ-Iodo-Abu-OMe is used as a building block for the synthesis of new compounds with potential biological activities, contributing to the discovery of novel drugs and therapeutic agents.
Used in Organic Synthesis:
(S)-Boc-γ-Iodo-Abu-OMe is used as a versatile intermediate for the synthesis of complex organic molecules, taking advantage of its reactive γ-iodo-aminobutyric acid moiety for further functionalization.
Used in Peptide Synthesis:
(S)-Boc-γ-Iodo-Abu-OMe is used as a key component in the assembly of peptides, where its Boc protecting group and OMe group facilitate the controlled stepwise synthesis of peptide sequences.
Used in Small Molecule Synthesis:
(S)-Boc-γ-Iodo-Abu-OMe is used as a starting material for the development of small molecules with specific biological targets, leveraging its unique structure for the introduction of diverse functional groups.

Check Digit Verification of cas no

The CAS Registry Mumber 101650-14-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,1,6,5 and 0 respectively; the second part has 2 digits, 1 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 101650-14:
(8*1)+(7*0)+(6*1)+(5*6)+(4*5)+(3*0)+(2*1)+(1*4)=70
70 % 10 = 0
So 101650-14-0 is a valid CAS Registry Number.

101650-14-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name methyl (2S)-4-iodo-2-[(2-methylpropan-2-yl)oxycarbonylamino]butanoate

1.2 Other means of identification

Product number -
Other names (S)-BOC-G-IODO-ABU-OME

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:101650-14-0 SDS

101650-14-0Relevant articles and documents

Rhodium(I) and Iridium(I) N-Heterocyclic carbene complexes of imidazolium functionalized amino acids and peptides

Daubit, Isabelle Marie,Wolf, Jonas,Metzler-Nolte, Nils

, (2020)

The conjugation of organometallic complexes to peptides is generally achieved through covalent organic linkages of the metal's ligand to the peptide. Examples of direct coordination to metal centers by amino acid side chain residues remain rare. In one such example, side chain methylation of the natural amino acid histidine (His) resulted in an imidazolium functionalized amino acid which was used for the synthesis of rhodium(I), iridium(I), iridium(III), palladium(II) and ruthenium(III) N-heterocyclic carbene (NHC) complexes of the single amino acid and peptides containing this amino acid. Here, we have synthesized two new, non-natural imidazolium functionalized amino acid derivatives, which were used for solid phase peptide synthesis and for the synthesis of [M(COD)(NHC)Cl] (COD = 1,5 cyclooctadiene) complexes of Rh(I) and Ir(I). In total, six new complexes of the single amino acids and four complexes where the amino acids are present in a peptide environment were synthesized. Their characterization provides convincing evidence of conversion of the imidazolium moiety to an NHC ligand and thus the presence of a direct metal-carbon bond between the metal center and the amino acid side chain. Therefore, our compounds represent unique examples of peptide-conjugated complexes that bear the potential to be used for the synthesis of N-heterocyclic carbene complexes conjugated to cancer cell targeting peptides.

Synthesis of Imidazole and Histidine-Derived Cross-Linkers as Analogues of GOLD and Desmosine

Sch?del, Nicole,Icik, Esra,Martini, Maike,Altevogt, Luca,Ramming, Isabell,Greulich, Andreas,Baro, Angelika,Bilitewski, Ursula,Laschat, Sabine

, p. 2260 - 2268 (2021/03/04)

Amino acid derivatives with a central cationic heterocyclic core (e.g., imidazolium) are biologically relevant cross-linkers of proteins and advanced glycation end (AGE) products. Here, imidazolium-containing cross-linkers were synthesized from imidazole or histidine by N-alkylation employing aspartate- and glutamate-derived mesylates as key step. Biological investigations were carried out to probe the biocompatibility of these compounds.

Nα-Fmoc-protected ω-azido- and ω-alkynyl-L- amino acids as building blocks for the synthesis of "clickable" peptides

Isaad, Alexandra Le Chevalier,Barbetti, Francesca,Rovero, Paolo,D'Ursi, Anna Maria,Chelli, Mario,Chorev, Michael,Papini, Anna Maria

experimental part, p. 5308 - 5314 (2009/06/18)

The growing interest in the 1,4-disubstituted-1,2,3-triazolyl moiety as an amide bond surrogate and its formation through very mild, chemoselective, and bioorthogonal CuI-catalyzed Huisgen 1,3-dipolar [3+2] cycloaddition of an alkynyl to an azi

P38 inhibitors and methods of use thereof

-

, (2008/06/13)

This invention relates to inhibitors of p38, and methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing the inhibitors and pharmaceutical compositions in the treatment and prevention of various disorders mediated by p38.

An efficient procedure for the preparation of 4-substituted 5-aminoimidazoles

McLaughlin, Mark,Mohareb, Rafat M.,Rapoport, Henry

, p. 50 - 54 (2007/10/03)

The preparation of O-methylimidates from α-aminonitriles and their subsequent co-cyclization with primary amines to afford 4-substituted 5-aminoimidazoles was studied. It was found that the mildly acidic pyridinium p-toluenesulfonate efficiently catalyzed each stage of the reaction sequence: (a) the formation of the O-methylimidates, (b) their co-cyclization with a variety of primary amines, and (c) certain derivatizations of the resultant heterocycles. The developed reaction conditions tolerate a wide variety of α-aminonitriles and primary amine co-reactants. Thus, it is possible to easily prepare a diverse array of substituted heterocyclic compounds in good yield. The requisite α-aminonitriles were synthesized either from amino acids or by phase-transfer alkylation of a glycine anion equivalent. The unstable free 5-aminoimidazoles were normally protected in situ to provide derivatives (methyl imidates or N,N-dimethylamidines) that were amenable to characterization.

AGENTS FOR IMAGING AND DIAGNOSTIC METHODS USING THEM

-

Page 24; 26, (2008/06/13)

The present invention provides novel compounds that bind selectively to cells undergoing perturbations and alterations of the normal organization of their plasma membrane, while binding to a lesser degree to cells having membranes of normal organization,

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