10176-71-3

Basic information

• Product Name: Scutellarein 4',7- dimethyl ether
• Synonyms: 4',7-Dimethoxy-5,6-dihydroxyflavone;5,6-Dihydroxy-4',7-dimethoxyflavone;Ladanein;Scutellarein 4',7- dimethyl ether;5,6-Dihydroxy-7,4'-dimethoxyflavone;BJ 486K;Ladanine;5,6-DIHYDROXY-7-METHOXY-2-(4-METHOXYPHENYL)-4H-CHROMEN-4-ONE
• CAS NO: 10176-71-3
• Molecular Formula: C₁₇H₁₄O₆
• Molecular Weight: 314.28946
• Mol File: 10176-71-3.mol

Chemical Properties

• Melting Point: 310-313℃
• Boiling Point: 565.7°C at 760 mmHg
• Flash Point: 212.4°C
• Appearance: /
• Density: 1.402g/cm³
• Vapor Pressure: 2.11E-13mmHg at 25°C
• Refractive Index: 1.645
• CAS DataBase Reference: Scutellarein 4',7- dimethyl ether(CAS DataBase Reference)
• NIST Chemistry Reference: Scutellarein 4',7- dimethyl ether(10176-71-3)
• EPA Substance Registry System: Scutellarein 4',7- dimethyl ether(10176-71-3)

Safety Data

• Hazardous Substances Data: 10176-71-3(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Scutellarein 4',7-dimethyl ether is used as a therapeutic agent for its potential health benefits, such as its antioxidant, anti-inflammatory, and neuroprotective properties. It is particularly valuable for its potential in treating various health conditions, including cardiovascular diseases, diabetes, and neurodegenerative disorders.
Used in Anticancer Applications:
In the field of oncology, scutellarein 4',7-dimethyl ether is used as an anti-cancer agent, where it inhibits the growth of cancer cells and induces apoptosis. Its potential to target and treat cancer cells makes it a promising candidate for further research and development in cancer therapy.
Used in Nutraceutical Industry:
Scutellarein 4',7-dimethyl ether is used as a nutraceutical ingredient for its health-promoting properties. Its antioxidant and anti-inflammatory effects contribute to overall wellness and may help in the prevention and management of various diseases.
Used in Cosmetic Industry:
Due to its antioxidant and anti-inflammatory properties, scutellarein 4',7-dimethyl ether is used in the cosmetic industry for skincare products. It may help protect the skin from oxidative stress and inflammation, promoting a healthier and more youthful appearance.
Used in Dietary Supplements:
Scutellarein 4',7-dimethyl ether is used as an ingredient in dietary supplements to provide consumers with the health benefits associated with this natural flavonoid compound. Its inclusion in supplements can support overall health and well-being, particularly in areas such as immune function, cognitive health, and cardiovascular health.

InChI:InChI=1/C17H14O6/c1-21-10-5-3-9(4-6-10)12-7-11(18)15-13(23-12)8-14(22-2)16(19)17(15)20/h3-8,19-20H,1-2H3

Upstream product

• 6962-57-8 3,6-dihydroxy-2,4-dimethoxyacetophenone 
• 794-94-5 p-Methoxybenzoic anhydride 
• 6938-19-8 6-hydroxy-5,7-dimethoxy-2-(4-methoxyphenyl)-4H-chromen-4-one 
• 1311993-73-3 5,6-dihydroxy-7,4'-dimethoxyflavone-6-O-α-D-rhamnosyl-(1->6)-β-D-glucose 
• 10176-68-8 4-hydroxy-2,6-dimethoxy-3-(3-(4-methoxyphenyl)-3-oxopropanoyl)phenyl 4-methoxybenzoate 
• 10176-70-2 5,7-dimethoxy-2-(4-methoxyphenyl)-4-oxo-4H-chromen-6-yl 4-methoxybenzoate 
• 90-24-4 2-hydroxy-4,6-dimethoxyacetophenone 
• 530-55-2 2,6-dimethoxy-p-quinone 
• 6563-66-2 5,6,7-trihydroxy-2-(4-methoxyphenyl)-4H-chromen-4-one 
• 74-88-4 methyl iodide 
• 7702-17-2 4-(acetyloxy)-3,5-dimethoxyphenyl acetate 
• 98452-84-7 Acetic acid 5,7-dimethoxy-2-(4-methoxy-phenyl)-4-oxo-4H-chromen-6-yl ester 

Downstream Products

• 197908-15-9 Toluene-4-sulfonic acid 6-hydroxy-7-methoxy-2-(4-methoxy-phenyl)-4-oxo-4H-chromen-5-yl ester 
• 1456770-94-7 C₁₈H₁₄O₆ 

Relevant articles and documents

Chemical constituents of the leaves of glochidion obliquum and their bioactivity

A new flavonoid glycoside, globlin A (1), and eleven known compounds were isolated from methanolic extracts of the leaves of Glochidion obliquum. The structure of this new compound was established with a combination of 2D NMR techniques (COSY, NOESY, HMQC

Synthesis and biological evaluation of methylated scutellarein analogs based on metabolic mechanism of scutellarin in vivo

Scutellarin (1) could be hydrolyzed into scutellarein (2) in vivo and then converted into methylated, sulfated and glucuronidated forms. In order to investigate the biological activities of these methylated metabolites, eight methylated analogs of scutellarein (2) were synthesized via semi-synthetic methods. The antithrombotic activities of these compounds were evaluated through the analyzation of prothrombin time (PT), activated partial thromboplastin time (APTT), thrombin time (TT) and fibrinogen (FIB). Their antioxidant activities were assessed by measuring their scavenging capacities toward 1,1-diphenyl-2-picrylhydrazyl radical (DPPH) and the ability to protect PC12 cells against H2O2-induced cytotoxicity. Furthermore, the physicochemical properties of these compounds including aqueous solubility and lipophilicity were also investigated. The results showed that 6-O-methylscutellarein (5) demonstrated potent antithrombotic activity, stronger antioxidant activity and balanced solubility and permeability compared with scutellarin (1), which warrants further development of 5 as a promising lead for the treatment of ischemic cerebrovascular disease.

A practical and economical high-yielding, six-step sequence synthesis of a flavone: Application to the multigram-scale synthesis of ladanein

Herein we report a short and economic synthesis of the antiviral flavonoid lead ladanein (1). Ladanein is obtained from 2,6-dimethoxyquinone (11) in six steps with 51% overall yield. After a high-yielding reductive acetylation and Fries rearrangement, the

Flavone derivatives and their use

The present invention relates to flavone derivatives and to compositions containing one or more of these flavone derivatives. The present invention further relates to flavone derivatives or compositions for use in the treatment and/or prevention of a vira

FLAVONE DERIVATIVES AND THEIR USE

The present invention relates to flavone derivatives and to compositions containing one or more of these flavone derivatives. The present invention further relates to fiavone derivatives or compositions for use in the treatment and/or prevention of a vira