1020959-71-0

Basic information

• Product Name: 2-(2-bromophenoxy)benzaldehyde
• Synonyms: 2-(2-bromophenoxy)benzaldehyde
• CAS NO: 1020959-71-0
• Molecular Formula: C₁₃H₉BrO₂
• Molecular Weight: 277.11336
• Mol File: 1020959-71-0.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-(2-bromophenoxy)benzaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-bromophenoxy)benzaldehyde(1020959-71-0)
• EPA Substance Registry System: 2-(2-bromophenoxy)benzaldehyde(1020959-71-0)

Safety Data

• Hazardous Substances Data: 1020959-71-0(Hazardous Substances Data)

Usage

General Description

2-(2-bromophenoxy)benzaldehyde is a chemical compound with the formula C13H9BrO2. It is an aromatic aldehyde with a bromine atom and a phenyl group attached to a benzene ring. 2-(2-bromophenoxy)benzaldehyde is commonly used as an intermediate in the synthesis of various organic compounds, particularly in the pharmaceutical and agrochemical industries. It has a wide range of applications, including as a building block in the production of pharmaceuticals, dyes, and polymers. Additionally, it can also be utilized in the field of organic synthesis for the preparation of various functionalized benzaldehyde derivatives.

Upstream product

• 95-56-7 2-hydroxybromobenzene 
• 100-52-7 benzaldehyde 
• 552-89-6 2-nitro-benzaldehyde 
• 446-52-6 2-Fluorobenzaldehyde 

Downstream Products

• 257-05-6 dibenzo[b,f]oxepine 
• 55164-22-2 9-methylene-9H-xanthene 
• 46410-70-2 1-phenoxy-2-vinylbenzene 
• 1372104-66-9 1-bromo-2-(2-vinylphenoxy)benzene 
• 90-46-0 9-hydroxyxanthene 
• 90-47-1 xanth-9-one 

Relevant articles and documents

Ni-Catalyzed Carbon-Carbon Bond-Forming Reductive Amination

This report describes a three-component, Ni-catalyzed reductive coupling that enables the convergent synthesis of tertiary benzhydryl amines, which are challenging to access by traditional reductive amination methodologies. The reaction makes use of iminium ions generated in situ from the condensation of secondary N-trimethylsilyl amines with benzaldehydes, and these species undergo reaction with several distinct classes of organic electrophiles. The synthetic value of this process is demonstrated by a single-step synthesis of antimigraine drug flunarizine (Sibelium) and high yielding derivatization of paroxetine (Paxil) and metoprolol (Lopressor). Mechanistic investigations support a sequential oxidative addition mechanism rather than a pathway proceeding via α-amino radical formation. Accordingly, application of catalytic conditions to an intramolecular reductive coupling is demonstrated for the synthesis of endo- and exocyclic benzhydryl amines.

Discovery of Pyrazine-Carboxamide-Diphenyl-Ethers as Novel Succinate Dehydrogenase Inhibitors via Fragment Recombination

The discovery of novel succinate dehydrogenase inhibitors (SDHIs) has attracted great attention worldwide. Herein, a fragment recombination strategy was proposed to design new SDHIs by understanding the ligand-receptor interaction mechanism of SDHIs. Thre

Palladium-Catalyzed Fluoroarylation of gem-Difluoroalkenes

A Pd-catalyzed fluoroarylation of gem-difluoroalkenes with aryl halides is reported. By taking advantage of the in situ generated α-CF3-benzylsilver intermediates derived from the nucleophilic addition of silver fluoride to gem-difluoroalkenes, this strategy bypasses the use of a strong base, thus enabling a mild and general synthetic method for ready access to non-symmetric α,α-disubstituted trifluoroethane derivatives.