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102169-44-8

102169-44-8

Identification

  • Product Name:4-Bromo-5-methylbenzene-1,2-diamine

  • CAS Number: 102169-44-8

  • EINECS:

  • Molecular Weight:201.066

  • Molecular Formula: C7H9BrN2

  • HS Code:2921590090

  • Mol File:102169-44-8.mol

Synonyms:4-broMo-5-Methylbenzene-1,2-diaMine;1,2-BenzenediaMine, 4-broMo-5-Methyl-;4-Bromo-5-methyl-1,2-benzenediamine

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Safety information and MSDS view more

  • Pictogram(s):Xn

  • Hazard Codes:Xn

  • Signal Word:no data available

  • Hazard Statement:no data available

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

  • Fire-fighting measures: Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

Supplier and reference price

  • Manufacture/Brand
  • Product Description
  • Packaging
  • Price
  • Delivery
  • Purchase
  • Manufacture/Brand:SynQuest Laboratories
  • Product Description:4-Bromo-5-methylbenzene-1,2-diamine
  • Packaging:5 g
  • Price:$ 408
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:SynQuest Laboratories
  • Product Description:4-Bromo-5-methylbenzene-1,2-diamine
  • Packaging:1 g
  • Price:$ 138
  • Delivery:In stock
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  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:4-Bromo-5-methyl-1,2-benzenediamine Aldrich
  • Packaging:1g
  • Price:$ 258
  • Delivery:In stock
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  • Manufacture/Brand:Matrix Scientific
  • Product Description:4-Bromo-5-methylbenzene-1,2-diamine 97%
  • Packaging:1g
  • Price:$ 115
  • Delivery:In stock
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  • Manufacture/Brand:Crysdot
  • Product Description:4-Bromo-5-methylbenzene-1,2-diamine 95+%
  • Packaging:25g
  • Price:$ 446
  • Delivery:In stock
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  • Manufacture/Brand:Crysdot
  • Product Description:4-Bromo-5-methylbenzene-1,2-diamine 95+%
  • Packaging:10g
  • Price:$ 248
  • Delivery:In stock
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  • Manufacture/Brand:Chemenu
  • Product Description:4-bromo-5-methylbenzene-1,2-diamine 95%
  • Packaging:10g
  • Price:$ 234
  • Delivery:In stock
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  • Manufacture/Brand:Chemenu
  • Product Description:4-bromo-5-methylbenzene-1,2-diamine 95%
  • Packaging:5g
  • Price:$ 153
  • Delivery:In stock
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  • Manufacture/Brand:Chemenu
  • Product Description:4-bromo-5-methylbenzene-1,2-diamine 95%
  • Packaging:25g
  • Price:$ 421
  • Delivery:In stock
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  • Manufacture/Brand:Biosynth Carbosynth
  • Product Description:4-Bromo-5-methylbenzene-1,2-diamine
  • Packaging:250 mg
  • Price:$ 115
  • Delivery:In stock
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Relevant articles and documentsAll total 3 Articles be found

Benzo[c][1,2,5]thiadiazole Donor-Acceptor Dyes: A Synthetic, Spectroscopic, and Computational Study

Barnsley, Jonathan E.,Shillito, Georgina E.,Larsen, Christopher B.,Van Der Salm, Holly,Wang, Lei E.,Lucas, Nigel T.,Gordon, Keith C.

, p. 1853 - 1866 (2016/04/08)

The synthesis, optical characterization and computational modeling of seven benzo[c][1,2,5]thiadiazole (BTD) donor-acceptor dyes are reported. These dyes have been studied using electrochemical analysis, electronic absorption, emission, and Raman and resonance Raman spectroscopies coupled with various density functional theoretical approaches. Crystal structure geometries on a number of these compounds are also reported. The optical spectra are dominated by low energy charge-transfer states; this may be modulated by the coupling between donor and acceptor through variation in donor energy, variation of the donor-acceptor torsion angle, and incorporation of an insulating bridge. These modifications result in a perturbation of the excitation energy for this charge-transfer transition of up to ~2000 cm-1. Emission spectra exhibit significant solvatochromisim, with Lippert-Mataga analysis yielding Δμ between 8 and 33 D. Predicted λmax, ε, and Raman cross sections calculated by M06L, B3LYP, PBE0, M06, CAM-B3LYP, and ωB97XD DFT functionals were compared to experimental results and analyzed using multivariate analysis, which shows that hybrid functionals with 20-27% HF best predict ground state absorption, while long-range corrected functionals best predict molecular polarizabilities.

SUBSTITUTED 5-AMINOPYRAZOLES AND USE THEREOF

-

Page/Page column 81-82, (2010/04/03)

The present application relates to novel substituted 5-aminopyrazoles, methods of production thereof, use thereof alone or in combinations for the treatment and/or prophylaxis of diseases and use thereof for the production of medicinal products for the treatment and/or prophylaxis of diseases.

Heterocyclic amide derivatives as RXR agonists for the treatment of dyslipidemia, hypercholesterolemia and diabetes

-

Page/Page column 29, (2010/11/26)

The present invention relates to compounds of Formula (I), methods for preparing these compounds, compositions, intermediates and derivatives thereof and for treating RXR mediated disorders. More particularly, the compounds of the present invention are RXR agonists useful for treating RXR mediated disorders.

Process route upstream and downstream products

Process route

4-bromo-5-methyl-2-nitrophenylamine
827-32-7

4-bromo-5-methyl-2-nitrophenylamine

4-bromo-5-methyl-1,2-o-phenylenediamine
102169-44-8

4-bromo-5-methyl-1,2-o-phenylenediamine

Conditions
Conditions Yield
With tin(ll) chloride; In ethanol; at 70 ℃;
89%
4-methyl-2-nitroaniline
89-62-3

4-methyl-2-nitroaniline

4-bromo-5-methyl-1,2-o-phenylenediamine
102169-44-8

4-bromo-5-methyl-1,2-o-phenylenediamine

Conditions
Conditions Yield
4-methyl-2-nitroaniline; With N-Bromosuccinimide; acetic acid; for 2.5h;
With acetic acid; zinc; In water; for 1h;
With ammonia; In water; pH=~ 7;
83%
4-bromo-5-methyl-1,2-di(tosylamino)benzene
335342-96-6

4-bromo-5-methyl-1,2-di(tosylamino)benzene

4-bromo-5-methyl-1,2-o-phenylenediamine
102169-44-8

4-bromo-5-methyl-1,2-o-phenylenediamine

Conditions
Conditions Yield
With sulfuric acid; for 3h; Reflux;
87%
2-bromo-4,5-dinitro-toluene
857001-14-0

2-bromo-4,5-dinitro-toluene

4-bromo-5-methyl-1,2-o-phenylenediamine
102169-44-8

4-bromo-5-methyl-1,2-o-phenylenediamine

Conditions
Conditions Yield
With ethanol; ammonia; at 120 ℃; under 14710.2 Torr; beim Behandeln des Reaktionsprodukts mit Zink-Pulver und aethanol. NaOH;
4-methyl-1,2-diaminobenzene
496-72-0

4-methyl-1,2-diaminobenzene

4-bromo-5-methyl-1,2-o-phenylenediamine
102169-44-8

4-bromo-5-methyl-1,2-o-phenylenediamine

Conditions
Conditions Yield
Multi-step reaction with 3 steps
1: pyridine / dichloromethane / 3 h / 0 - 20 °C
2: sodium acetate; acetic acid; bromine / 3 h / 0 °C / Reflux
3: sulfuric acid / 3 h / Reflux
With pyridine; sulfuric acid; bromine; sodium acetate; acetic acid; In dichloromethane;
N,N'-(4-methyl-1,2-phenylene)bis(4-methylbenzenesulfonamide)
70376-38-4

N,N'-(4-methyl-1,2-phenylene)bis(4-methylbenzenesulfonamide)

4-bromo-5-methyl-1,2-o-phenylenediamine
102169-44-8

4-bromo-5-methyl-1,2-o-phenylenediamine

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1: sodium acetate; acetic acid; bromine / 3 h / 0 °C / Reflux
2: sulfuric acid / 3 h / Reflux
With sulfuric acid; bromine; sodium acetate; acetic acid;
5-bromo-4-methyl-2-nitroaniline
40371-63-9

5-bromo-4-methyl-2-nitroaniline

4-bromo-5-methyl-1,2-o-phenylenediamine
102169-44-8

4-bromo-5-methyl-1,2-o-phenylenediamine

Conditions
Conditions Yield
With sodium hydroxide; zinc;
2-bromo-4-nitrotoluene
7745-93-9

2-bromo-4-nitrotoluene

4-bromo-5-methyl-1,2-o-phenylenediamine
102169-44-8

4-bromo-5-methyl-1,2-o-phenylenediamine

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1: sulfuric acid; nitric acid
2: ethanol; NH3 / 120 °C / 14710.2 Torr / beim Behandeln des Reaktionsprodukts mit Zink-Pulver und aethanol. NaOH
With ethanol; sulfuric acid; ammonia; nitric acid;
1-(cyclopropylmethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole
1000801-75-1

1-(cyclopropylmethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

4-bromo-5-methyl-1,2-o-phenylenediamine
102169-44-8

4-bromo-5-methyl-1,2-o-phenylenediamine

4-[1-(cyclopropylmethyl)-1H-pyrazol-4-yl]-5-methylbenzene-1,2-diamine

4-[1-(cyclopropylmethyl)-1H-pyrazol-4-yl]-5-methylbenzene-1,2-diamine

Conditions
Conditions Yield
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate; In propan-1-ol; water; at 120 ℃; for 2h; Inert atmosphere;
1-(cyclopropylmethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole
1000801-75-1

1-(cyclopropylmethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

4-bromo-5-methyl-1,2-o-phenylenediamine
102169-44-8

4-bromo-5-methyl-1,2-o-phenylenediamine

4-[1-(cyclopropylmethyl)-1H-pyrazol-4-yl]-5-fluorobenzene-1,2-diamine

4-[1-(cyclopropylmethyl)-1H-pyrazol-4-yl]-5-fluorobenzene-1,2-diamine

Conditions
Conditions Yield
With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; sodium carbonate; In tetrahydrofuran; water; at 60 ℃;

Global suppliers and manufacturers

Global( 36) Suppliers
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  • Amadis Chemical Co., Ltd.
  • Business Type:Lab/Research institutions
  • Contact Tel:86-571-89925085
  • Emails:sales@amadischem.com
  • Main Products:29
  • Country:China (Mainland)
  • Win-Win chemical Co.Ltd
  • Business Type:Lab/Research institutions
  • Contact Tel:0086-577-64498589
  • Emails:sales@win-winchemical.com
  • Main Products:55
  • Country:China (Mainland)
  • Finetech Industry Limited
  • Business Type:Trading Company
  • Contact Tel:86-27-87465837
  • Emails:sales@finetechnology-ind.com
  • Main Products:29
  • Country:China (Mainland)
  • Antimex Chemical Limied
  • Business Type:Lab/Research institutions
  • Contact Tel:0086-21-50563169
  • Emails:anthony@antimex.com
  • Main Products:163
  • Country:China (Mainland)
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