827-32-7 Usage
Description
4-Bromo-5-methyl-2-nitroaniline is a chemical compound with the molecular formula C7H7BrN2O2. It is a yellow crystalline solid that is commonly used as an intermediate in the synthesis of various organic compounds, particularly dyes and pharmaceuticals. Classified as a substituted aniline, it is a derivative of aniline with substitutions at the 4-bromo, 5-methyl, and 2-nitro positions. 4-Bromo-5-methyl-2-nitroaniline is known to be a mild to moderate skin irritant and may cause eye irritation upon contact. It is also considered toxic if ingested, inhaled, or absorbed through the skin, necessitating appropriate safety precautions during handling.
Uses
Used in Pharmaceutical Industry:
4-Bromo-5-methyl-2-nitroaniline is used as a chemical intermediate for the synthesis of various pharmaceuticals. Its unique molecular structure allows it to be a key component in the development of new drugs, contributing to the advancement of medicinal chemistry.
Used in Dye Industry:
In the dye industry, 4-Bromo-5-methyl-2-nitroaniline is utilized as an intermediate in the production of various dyes. Its chemical properties enable it to be a vital building block in the creation of a wide range of colorants used in different applications, such as textiles, plastics, and printing inks.
Used in Chemical Research:
4-Bromo-5-methyl-2-nitroaniline is also employed in chemical research as a model compound for studying the properties and reactions of substituted anilines. Its unique structure provides valuable insights into the behavior of similar compounds, aiding in the development of new synthetic methods and understanding the underlying chemical principles.
Check Digit Verification of cas no
The CAS Registry Mumber 827-32-7 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 8,2 and 7 respectively; the second part has 2 digits, 3 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 827-32:
(5*8)+(4*2)+(3*7)+(2*3)+(1*2)=77
77 % 10 = 7
So 827-32-7 is a valid CAS Registry Number.
827-32-7Relevant articles and documents
KINASE INHIBITORS AND USES THEREOF
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Paragraph 0817; 0820-0821, (2022/02/15)
Provided are cyclic iminopyridimdine compounds and their bicyclic derivatives, pharmaceutical compositions comprising such compounds, and methods of using such compounds or compositions, such as methods of treating a proliferation disorder, such as a cancer or a tumor, or in some embodiments disease or disorders related to the dysregulation of kinase such as, but not limited to kinases such as MAPK, PDGFR, Src, PAKs, c-Kit, EphA2, EphB4, FGFR, Axl, and c-Met.
FUSED PYRAZINE DERIVATIVES AS KINASE INHIBITORS
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Page/Page column 40, (2010/06/11)
A series of quinoxaline derivatives, and analogues thereof, which are functionalised further by a substituted phenyl or pyridinyl moiety, being selective inhibitors of PO kinase enzymes, are accordingly of benefit in medicine, for example in the treatment of inflammatory, autoimmune, cardiovascular, neurodegenerative, metabolic, oncological, nociceptive or ophthalmic conditions.
Crystal packing: An examination of the packing of molecules approximately isosteric with 4,5-dichlorophthalic anhydride
Britton, Doyle,Noland, Wayland E.,Pinnow, Matthew J.,Young Jr., Victor G.
, p. 1175 - 1192 (2007/10/03)
The crystal structures of five 5,6-disubstituted benzofurazan 1-oxides are presented and compared with five previously reported structures: three polymorphs of 5,6-dichlorobenzofurazan 1-oxide plus 4,5-dichloro- and 4,5-dibromophthalic anhydride. All but one of these compounds pack with similar two-dimensional layers. The benzofurazan oxides all show disorder about a crystallographic twofold or pseudo-twofold axis. In addition, six complexes of phthalic anhydride and benzofurazan oxides are reported. With the packing in the complexes principally directed by the π complexing, the disorder, invariably found in the uncomplexed benzofurazan oxides, is diminished, and, in two cases, eliminated.