1027345-08-9

Basic information

• Product Name: 4-Fluoro-3-(trifluoromethylsulfonyl) benzenesulfonamide
• Synonyms: 4-Fluoro-3-(trifluoromethylsulfonyl) benzenesulfonamide;4-fluoro-3-(trifluoroMethane)sulfonylbenzene-1-sulfonaMide;BenzenesulfonaMide, 4-fluoro-3-[(trifluoroMethyl)sulfonyl]-;EOS-62146
• CAS NO: 1027345-08-9
• Molecular Formula: C₇H₅F₄NO₄S₂
• Molecular Weight: 307.2425128
• Product Categories: Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds
• Mol File: 1027345-08-9.mol

Chemical Properties

• Boiling Point: 436.9±55.0 °C(Predicted)
• Appearance: /
• Density: 1.699
• Storage Temp.: 2-8°C
• Solubility: Dichloromethane, DMSO, Ethanol, Methanol
• PKA: 9.30±0.60(Predicted)
• CAS DataBase Reference: 4-Fluoro-3-(trifluoromethylsulfonyl) benzenesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Fluoro-3-(trifluoromethylsulfonyl) benzenesulfonamide(1027345-08-9)
• EPA Substance Registry System: 4-Fluoro-3-(trifluoromethylsulfonyl) benzenesulfonamide(1027345-08-9)

Safety Data

• Hazardous Substances Data: 1027345-08-9(Hazardous Substances Data)

Usage

Chemical Properties

Tan Solid

Uses

An intermediate in the production of anticancer drugs

Upstream product

• 88-74-4 2-nitro-aniline 
• 2905-21-7 2-fluorobenzenesulfonyl chloride 
• 52200-99-4 2-fluoro-benzenesulfonyl fluoride 
• 365-33-3 2-nitrobenzenediazonium tetrafluoroborate 
• 1978-16-1 1-fluoro-2-(trifluoromethylsulfanyl)benzene 
• 2557-78-0 2-fluorothiophenol 
• 2358-41-0 1-fluoro-2-[(trifluoromethyl)sulfonyl]benzene 
• 1027345-07-8 4-fluoro-3-(trifluoromethylsulfonyl)benzene-1-sulfonyl chloride 

Downstream Products

• 1027345-13-6 (R)-N,N-dimethyl-4-(phenylthio)-3-(4-sulfamoyl-2-(trifluoromethylsulfonyl)phenylamino)butanamide 
• 1027345-11-4 (R)-4-(4-morpholino-4-oxo-1-(phenylthio)butan-2-ylamino)-3-(trifluoromethylsulfonyl)benzenesulfonamide 
• 1027345-12-5 [4-((R)-3-morpholin-4-yl-1-phenylsulfanyl-methyl-propylamino)-3-trifluoromethanesulfonyl]benzenesulfonamide 
• 1027345-14-7 (R)-4-((4-(dimethylamino)-1-(phenylthio)butan-2-yl)amino)-3-((trifluoromethyl)sulfonyl)benzenesulfonamide 
• 1357575-02-0 (R)-methyl 4-(phenylthio)-3-(4-sulfamoyl-2-(trifluoromethylsulfonyl)phenylamino)butanoate 

Relevant articles and documents

Method for producing 4-fluoro-3-(trifluoromethylsulfonyl)benzenesulfonamide

The invention provides a method for producing 4-fluoro-3-(trifluoromethylsulfonyl)benzenesulfonamide. 2-nitroaniline is used as an initial raw material, is subjected to diazotization reaction, trifluoromethyl sulfonation reaction, fluoronation, chlorosulfonation reaction, and is reacted with ammonium hydroxide to finally produce the 4-fluoro-3-(trifluoromethylsulfonyl)benzenesulfonamide. Comparedwith reported synthesis methods, the method for producing the 4-fluoro-3-(trifluoromethylsulfonyl)benzenesulfonamide has the advantages that the reaction yield of the synthesis route is high, used reaction agents are economic and easy to obtain, reaction conditions are mild and controllable, and in a reaction process, column chromatography and purification are not needed, so that the method for producing the 4-fluoro-3-(trifluoromethylsulfonyl)benzenesulfonamide has wide commercial application prospects.

ACYLSULFONAMIDE DERIVATIVES FOR TREATING SENESCENCE-ASSOCIATED DISEASES AND DISORDERS

Compounds represented by Formula (I) and (II) and salts thereof are described herein. The compounds or salts of Formula (I) and (II) may be used to treat senescence-associated diseases and disorders.

INHIBITING B-CELL LYMPHOMA 2 (BCL-2) AND RELATED PROTEINS

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CHEMICAL COMPOUNDS

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ABT-263, a newly developed Bcl-2 inhibitor, was efficiently synthesized. The key intermediates 4-(4-{[2-(4-chlorophenyl)-5,5-dimethylcyclohex-1-enyl] methyl}piperazin-1-yl)benzoic acid and 4-fluoro-3-[(trifluoromethyl)sulfonyl] benzenesulfonamide were eff