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4-Fluoro-3-(trifluoromethylsulfonyl) benzenesulfonamide is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • SAGECHEM/4-Fluoro-3-(trifluoromethylsulfonyl) benzenesulfonamide/SAGECHEM/Manufacturer in China

    Cas No: 1027345-08-9

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  • 1027345-08-9 Structure
  • Basic information

    1. Product Name: 4-Fluoro-3-(trifluoromethylsulfonyl) benzenesulfonamide
    2. Synonyms: 4-Fluoro-3-(trifluoromethylsulfonyl) benzenesulfonamide;4-fluoro-3-(trifluoroMethane)sulfonylbenzene-1-sulfonaMide;BenzenesulfonaMide, 4-fluoro-3-[(trifluoroMethyl)sulfonyl]-;EOS-62146
    3. CAS NO:1027345-08-9
    4. Molecular Formula: C7H5F4NO4S2
    5. Molecular Weight: 307.2425128
    6. EINECS: N/A
    7. Product Categories: Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds
    8. Mol File: 1027345-08-9.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 436.9±55.0 °C(Predicted)
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 1.699
    6. Refractive Index: N/A
    7. Storage Temp.: 2-8°C
    8. Solubility: Dichloromethane, DMSO, Ethanol, Methanol
    9. PKA: 9.30±0.60(Predicted)
    10. CAS DataBase Reference: 4-Fluoro-3-(trifluoromethylsulfonyl) benzenesulfonamide(CAS DataBase Reference)
    11. NIST Chemistry Reference: 4-Fluoro-3-(trifluoromethylsulfonyl) benzenesulfonamide(1027345-08-9)
    12. EPA Substance Registry System: 4-Fluoro-3-(trifluoromethylsulfonyl) benzenesulfonamide(1027345-08-9)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1027345-08-9(Hazardous Substances Data)

1027345-08-9 Usage

Chemical Properties

Tan Solid

Uses

An intermediate in the production of anticancer drugs

Check Digit Verification of cas no

The CAS Registry Mumber 1027345-08-9 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,2,7,3,4 and 5 respectively; the second part has 2 digits, 0 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 1027345-08:
(9*1)+(8*0)+(7*2)+(6*7)+(5*3)+(4*4)+(3*5)+(2*0)+(1*8)=119
119 % 10 = 9
So 1027345-08-9 is a valid CAS Registry Number.

1027345-08-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-fluoro-3-(trifluoromethylsulfonyl)benzenesulfonamide

1.2 Other means of identification

Product number -
Other names 4-fluoro-3-(trifluoromethylsulfonyl)benzenesulfamide

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1027345-08-9 SDS

1027345-08-9Relevant articles and documents

Method for producing 4-fluoro-3-(trifluoromethylsulfonyl)benzenesulfonamide

-

, (2019/07/04)

The invention provides a method for producing 4-fluoro-3-(trifluoromethylsulfonyl)benzenesulfonamide. 2-nitroaniline is used as an initial raw material, is subjected to diazotization reaction, trifluoromethyl sulfonation reaction, fluoronation, chlorosulfonation reaction, and is reacted with ammonium hydroxide to finally produce the 4-fluoro-3-(trifluoromethylsulfonyl)benzenesulfonamide. Comparedwith reported synthesis methods, the method for producing the 4-fluoro-3-(trifluoromethylsulfonyl)benzenesulfonamide has the advantages that the reaction yield of the synthesis route is high, used reaction agents are economic and easy to obtain, reaction conditions are mild and controllable, and in a reaction process, column chromatography and purification are not needed, so that the method for producing the 4-fluoro-3-(trifluoromethylsulfonyl)benzenesulfonamide has wide commercial application prospects.

ACYLSULFONAMIDE DERIVATIVES FOR TREATING SENESCENCE-ASSOCIATED DISEASES AND DISORDERS

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, (2017/07/14)

Compounds represented by Formula (I) and (II) and salts thereof are described herein. The compounds or salts of Formula (I) and (II) may be used to treat senescence-associated diseases and disorders.

INHIBITING B-CELL LYMPHOMA 2 (BCL-2) AND RELATED PROTEINS

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Paragraph 00151, (2017/09/05)

Novel compounds inhibiting anti-apoptosis proteins B-cell lymphoma 2 (Bcl-2) and Bcl-XL include compounds of formula (I) and formula (II) disclosed herein, as well as liposome compositions comprising Bcl-2 inhibitor compounds. These compositions are usefu

CHEMICAL COMPOUNDS

-

Page/Page column 33, (2012/02/15)

The present invention relates to compounds of Formula (I): and to their salts, pharmaceutical compositions, methods of use, and methods for their preparation. These compounds inhibit Bcl-2 and/or Bcl-XL activities and may be used for the treatment of cancer.

Profiling small molecule inhibitors against helix-receptor interactions: The Bcl-2 family inhibitor BH3I-1 potently inhibits p53/hDM2

Porter, Jason R.,Helmers, Mark R.,Wang, Ping,Furman, Jennifer L.,Joy, Stephen T.,Arora, Paramjit S.,Ghosh, Indraneel

supporting information; experimental part, p. 8020 - 8022 (2011/01/03)

We validate a practical methodology for the rapid profiling of small molecule inhibitors of protein-protein interactions. We find that a well known BH3 family inhibitor can potently inhibit the p53/hDM2 interaction.

Processes To Make Apoptosis Promoters

-

Page/Page column 34, (2009/12/28)

Processes to make compounds, including N-acylsulfonamide apoptosis promoters are disclosed.

Discovery of an orally bioavailable small molecule inhibitor of prosurvival B-cell lymphoma 2 proteins

Park, Cheol-Min,Bruncko, Milan,Adickes, Jessica,Bauch, Joy,Ding, Hong,Kunzer, Aaron,Marsh, Kennan C.,Nimmer, Paul,Shoemaker, Alexander R.,Song, Xiaohong,Tahir, Stephen K.,Tse, Christin,Wang, Xilu,Wendt, Michael D.,Yang, Xiufen,Zhang, Haichao,Fesik, Stephen W.,Rosenberg, Saul H.,Elmore, Steven W.

experimental part, p. 6902 - 6915 (2009/11/30)

Overexpression of prosurvival proteins such as Bcl-2 and Bcl-XL has been correlated with tumorigenesis and resistance to chemotherapy, and thus, the development of antagonists of these proteins may provide a novel means for the treatment of can

ARYLSULFONAMIDE COMPOUNDS

-

Page/Page column 30; 31, (2008/12/05)

The invention relates generally to small molecules that mimic the biological activity of certain peptides and proteins, to compositions containing them and to their use. In particular, the invention relates to compounds of the general formula (I) that mim

An efficient synthesis of ABT-263, a novel inhibitor of antiapoptotic Bcl-2 proteins

Wang, Guangjun,Zhang, Hushan,Zhou, Jing,Ha, Chengyong,Pei, Duanqing,Ding, Ke

experimental part, p. 2398 - 2404 (2009/04/07)

ABT-263, a newly developed Bcl-2 inhibitor, was efficiently synthesized. The key intermediates 4-(4-{[2-(4-chlorophenyl)-5,5-dimethylcyclohex-1-enyl] methyl}piperazin-1-yl)benzoic acid and 4-fluoro-3-[(trifluoromethyl)sulfonyl] benzenesulfonamide were eff

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