1978-16-1

Basic information

• Product Name: 1-Fluoro-2-(trifluoromethyl)thio-benzene
• Synonyms: 1-Fluoro-2-(trifluoromethyl)thio-benzene;1-Fluoro-2-(trifluoromethyl)thio-benzene DISCONTINUED. UNSTABLE;o-Fluorophenyl TrifluoroMethyl Sulfide;Benzene, 1-fluoro-2-[(trifluoroMethyl)thio]-;4-Fluorophenyl trifluoroMethyl sulphide 1-Fluoro-4-(trifluoroMethylthio)benzene
• CAS NO: 1978-16-1
• Molecular Formula: C₇H₄F₄S
• Molecular Weight: 196.1652728
• Product Categories: harmaceuticals;Aromatics;Intermediates & Fine Chemicals;Sulfur & Selenium Compounds
• Mol File: 1978-16-1.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 145-146 °C
• Appearance: /
• Density: 1.170 g/cm3
• Solubility: Chloroform, Dichloromethane, DMSO, Ether
• CAS DataBase Reference: 1-Fluoro-2-(trifluoromethyl)thio-benzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Fluoro-2-(trifluoromethyl)thio-benzene(1978-16-1)
• EPA Substance Registry System: 1-Fluoro-2-(trifluoromethyl)thio-benzene(1978-16-1)

Safety Data

• Hazardous Substances Data: 1978-16-1(Hazardous Substances Data)

Usage

Chemical Properties

Red Oil

Uses

An intermediate in the production of anticancer drugs and cell death regulators.

Upstream product

• 2314-97-8 iodotrifluoromethane 
• 2557-78-0 2-fluorothiophenol 
• 655-20-9 2-fluorothioanisole 

Downstream Products

• 1619923-36-2 (R)-3-(1-(3-(4-(N-(4-(4-(3-(2-(4-chlorophenyl)-1-isopropyl-5-methyl-4-(methylsulfonyl)-1H-pyrrol-3-yl)-5-fluorophenyl)piperazin-1-yl)phenyl)sulfamoyl)-2-(trifluoromethylsulfonyl)phenylamino)-4-(phenylthio)butyl)piperidine-4-carbonyloxy)propylphosphonic acid 

Relevant articles and documents

Process for preparing sulfonamide compounds

The invention relates to a process for preparing sulfonamide compounds. The sulfonamide compound is an inhibitor of Bcl-2/Bcl-xL and is prepared from a compound (3R)-1-(3-(4-(4-(4-(3-(2-(4-chlorphenyl)-1-isopropyl-4-methylsulfonyl-5-methyl-1H-pyrrole-3-yl

Method for producing 4-fluoro-3-(trifluoromethylsulfonyl)benzenesulfonamide

The invention provides a method for producing 4-fluoro-3-(trifluoromethylsulfonyl)benzenesulfonamide. 2-nitroaniline is used as an initial raw material, is subjected to diazotization reaction, trifluoromethyl sulfonation reaction, fluoronation, chlorosulfonation reaction, and is reacted with ammonium hydroxide to finally produce the 4-fluoro-3-(trifluoromethylsulfonyl)benzenesulfonamide. Comparedwith reported synthesis methods, the method for producing the 4-fluoro-3-(trifluoromethylsulfonyl)benzenesulfonamide has the advantages that the reaction yield of the synthesis route is high, used reaction agents are economic and easy to obtain, reaction conditions are mild and controllable, and in a reaction process, column chromatography and purification are not needed, so that the method for producing the 4-fluoro-3-(trifluoromethylsulfonyl)benzenesulfonamide has wide commercial application prospects.

Discovery of an orally bioavailable small molecule inhibitor of prosurvival B-cell lymphoma 2 proteins

Overexpression of prosurvival proteins such as Bcl-2 and Bcl-XL has been correlated with tumorigenesis and resistance to chemotherapy, and thus, the development of antagonists of these proteins may provide a novel means for the treatment of can