2358-41-0

Basic information

• Product Name: 1-FLUORO-2-[(TRIFLUOROMETHYL)SULFONYL]BENZENE
• Synonyms: 1-FLUORO-2-[(TRIFLUOROMETHYL)SULFONYL]BENZENE;1-fluoro-2-(trifluoroMethane)sulfonylbenzene;o-Fluorophenyl TrifluoroMethyl Sulfone;Benzene, 1-fluoro-2-[(trifluoroMethyl)sulfonyl]-;2-Fluorophenyl trifluoromethyl sulfone;1-Fluoro-2-((trifluoromethyl);EOS-62148
• CAS NO: 2358-41-0
• Molecular Formula: C₇H₄F₄O₂S
• Molecular Weight: 228.1640728
• Product Categories: Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds
• Mol File: 2358-41-0.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 246.1°C at 760 mmHg
• Flash Point: 102.7°C
• Appearance: /
• Density: 1.502g/cm³
• Vapor Pressure: 0.0433mmHg at 25°C
• Refractive Index: 1.448
• Solubility: Chloroform, Dichloromethane, DMSO
• CAS DataBase Reference: 1-FLUORO-2-[(TRIFLUOROMETHYL)SULFONYL]BENZENE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-FLUORO-2-[(TRIFLUOROMETHYL)SULFONYL]BENZENE(2358-41-0)
• EPA Substance Registry System: 1-FLUORO-2-[(TRIFLUOROMETHYL)SULFONYL]BENZENE(2358-41-0)

Safety Data

• Hazardous Substances Data: 2358-41-0(Hazardous Substances Data)

Usage

InChI:InChI=1/C7H4F4O2S/c8-5-3-1-2-4-6(5)14(12,13)7(9,10)11/h1-4H

Upstream product

• 382-70-7 1-chloro-2-(trifluoromethylsulfonyl)benzene 
• 456-56-4 phenyl trifluoromethylsulfide 
• 108-98-5 thiophenol 
• 426-58-4 (trifluoromethylsulfonyl)benzene 
• 365-33-3 2-nitrobenzenediazonium tetrafluoroborate 
• 88-74-4 2-nitro-aniline 
• 2557-78-0 2-fluorothiophenol 
• 1034926-54-9 bis(2-fluorophenyl)iodonium tetrafluoroborate 
• 2926-29-6 Langlois reagent 
• 1202186-81-9 (2-fluorophenyl)(mesityl)iodonium trifluoromethanesulfonate 
• 52200-99-4 2-fluoro-benzenesulfonyl fluoride 
• 81290-20-2 (trifluoromethyl)trimethylsilane 
• 655-20-9 2-fluorothioanisole 
• 1644-87-7 1-nitro-2-[(trifluoromethyl)thio]benzene 

Downstream Products

• 1027345-07-8 4-fluoro-3-(trifluoromethylsulfonyl)benzene-1-sulfonyl chloride 
• 1619923-36-2 (R)-3-(1-(3-(4-(N-(4-(4-(3-(2-(4-chlorophenyl)-1-isopropyl-5-methyl-4-(methylsulfonyl)-1H-pyrrol-3-yl)-5-fluorophenyl)piperazin-1-yl)phenyl)sulfamoyl)-2-(trifluoromethylsulfonyl)phenylamino)-4-(phenylthio)butyl)piperidine-4-carbonyloxy)propylphosphonic acid 
• 920517-79-9 N-(4-(4-((2-(4-chlorophenyl)-5,5-dimethylcyclohex-1-en-1-yl)methyl)piperazin-1-yl)benzoyl)-4-(((1R)-3-(diethylamino)-1-((phenylsulfanyl)methyl)propyl)amino)-3-((trifluoromethyl)sulfonyl)benzenesulfonamide 

Relevant articles and documents

Process for preparing sulfonamide compounds

The invention relates to a process for preparing sulfonamide compounds. The sulfonamide compound is an inhibitor of Bcl-2/Bcl-xL and is prepared from a compound (3R)-1-(3-(4-(4-(4-(3-(2-(4-chlorphenyl)-1-isopropyl-4-methylsulfonyl-5-methyl-1H-pyrrole-3-yl

Method for producing 4-fluoro-3-(trifluoromethylsulfonyl)benzenesulfonamide

The invention provides a method for producing 4-fluoro-3-(trifluoromethylsulfonyl)benzenesulfonamide. 2-nitroaniline is used as an initial raw material, is subjected to diazotization reaction, trifluoromethyl sulfonation reaction, fluoronation, chlorosulfonation reaction, and is reacted with ammonium hydroxide to finally produce the 4-fluoro-3-(trifluoromethylsulfonyl)benzenesulfonamide. Comparedwith reported synthesis methods, the method for producing the 4-fluoro-3-(trifluoromethylsulfonyl)benzenesulfonamide has the advantages that the reaction yield of the synthesis route is high, used reaction agents are economic and easy to obtain, reaction conditions are mild and controllable, and in a reaction process, column chromatography and purification are not needed, so that the method for producing the 4-fluoro-3-(trifluoromethylsulfonyl)benzenesulfonamide has wide commercial application prospects.

ACYLSULFONAMIDE DERIVATIVES FOR TREATING SENESCENCE-ASSOCIATED DISEASES AND DISORDERS

Compounds represented by Formula (I) and (II) and salts thereof are described herein. The compounds or salts of Formula (I) and (II) may be used to treat senescence-associated diseases and disorders.