10440-43-4Relevant articles and documents
Syntheses of 7-chloro-4-substituted aminoquinolines and their in vitro ability to produce methemoglobin in canine hemolysate
Srivastava, Sandhya,Tewari, Swati,Srivastava, Sanjay K.,Chauhan,Bhaduri,Puri,Pandey
, p. 2741 - 2746 (1997)
Synthesis of aminoquinoline derivatives (2-15) and their in vitro effects on methemoglobin formation and methemoglobin reductase activity are delineated. Some of the screened compounds have shown considerable methemoglobin toxicity.
Design, synthesis, X-ray crystallographic study and anticancer activity of novel 4-(7-chloro-1-methylquinolin-4-(1H)-ylideneamino)-phenyl-3-(dimethylamino)-prop-2-en-1-one
Ghorab, Mostafa M.,Alsaid, Mansour S.,Ghabbour, Hazem A.,Fun, Hoong-Kun
, p. 8497 - 8500 (2014)
The disease of cancer has been ranked second after cardiovascular diseases and plant-derived molecules have played an important role for the treatment of cancer. On the account of the reported anticancer activity of quinolines containing the different bio
Synthesis of novel analogs of 2-pyrazoline obtained from [(7-chloroquinolin-4-yl)amino]chalcones and hydrazine as potential antitumor and antimalarial agents
Insuasty, Braulio,Montoya, Alba,Becerra, Diana,Quiroga, Jairo,Abonia, Rodrigo,Robledo, Sara,Vélez, Ivan Darió,Upegui, Yulieth,Nogueras, Manuel,Cobo, Justo
, p. 252 - 262 (2013)
A new series of N-acetyl and N-formyl-pyrazoline derivatives 6 and 7-8 were synthesized by cyclocondensation reaction of [(7-chloroquinolin-4-yl)amino] chalcones with hydrazine hydrate in acetic acid and hydrazine hydrate in formic acid respectively. Thes
[(7-chloroquinolin-4-YL)amino]acetophenones and their copper(II) derivatives: Synthesis, characterization, computational studies and antimalarial activity
Parra, Yonathan de J.,Andueza L, Felix D.,Ferrer M, Rosa E.,Colmenarez, Julia Bruno,Acosta, María E.,Charris, Jaime,Rosenthal, Philip J.,Gut, Jiri
, p. 962 - 987 (2019/11/13)
The synthesis of the compounds [(7-chloroquinolin-4-yl)amino]acetophenones (4, 5) and their copper(II) complexes (4a, 5a) is reported. The compounds were characterized using a wide range of spectroscopic and spectrometric techniques, such as FTIR, UV-vis,
Substituted quinolinyl chalcones and quinolinyl pyrimidines as a new class of anti-infective agents
Sharma, Moni,Chaturvedi, Vinita,Manju,Bhatnagar, Shalini,Srivastava, Kumkum,Puri,Chauhan, Prem M.S.
experimental part, p. 2081 - 2091 (2009/09/25)
Frequency of tuberculosis and malaria is progressively increasing worldwide. New emerging strain of bacterium and resistance to currently available drugs make this field more conscientious and alarming. In this connection a series of substituted quinoliny
Microwave-accelerated solvent- and catalyst-free synthesis of 4-aminoaryl/alkyl-7-chloroquinolines and 2-aminoaryl/alkylbenzothiazoles
Motiwala, Hashim F.,Kumar, Raj,Chakraborti, Asit K.
, p. 369 - 374 (2008/02/11)
An efficient synthesis of 4-aminoaryl/alkyl-7-chloroquinolines and 2-aminoaryl/alkylbenzothiazoles has been developed by microwave-accelerated regioselective aromatic nucleophilic substitution of 4,7-dichloroquinoline and 2-chlorobenzothiazole with aromatic and aliphatic amines under solvent-free conditions in the absence of any added protic or Lewis acid catalyst. Chemoselective reaction with the amino group in preference to the phenolic hydroxy group was observed. Thus, the treatment of 4,7-dichloroquinoline (1 equiv.) with a mixture of aniline (2 equiv.) and phenol (2 equiv.) afforded exclusive formation of 4-aminophenyl-7-chloroquinoline. When 4,7-dichloroquinoline (1 equiv.) was separately treated with 2-aminophenol (2 equiv.) and 4-aminophenol (2 equiv.), 4-(2'-hydroxyphenyl)-7-chloroquinoline and 4-(4'-hydroxyphenyl)-7-chloroquinoline, respectively, were formed. CSIRO 2007.
3-Cyano-4,6-disubstituted-2(1H)-imino or oxopyridines: New antineoplastic agents with high selectivity towards leukemia cell lines
Abadi,Al-Khamees
, p. 319 - 324 (2007/10/03)
Two series of 3-cyano-2(1H)-oxopyridine and 3-cyano-2(1H)-iminopyridine derivatives carrying various aryl substituents at position 4 and (4-((7- chloro or trifluoromethylquinol-4-yl)amino)phenyl) substituent at position 6 were synthesized and evaluated fo
Some Reactions with 4-(p-Cinnamoylanilino)quinolines
Kamel, M. M.,Gadalla, K. Z.,El-Hamouly, W. S.,El-Wassimi, M. T.
, p. 661 - 663 (2007/10/02)
For possible biological activity, the title compounds were prepared and allowed to condense with hydrazine hydrate, phenyl hydrazine, hydroxylamine HCl, urea and thiourea to give the pyrazolines 3, isoxazolines 4, oxo and thioxopyrimidines 5, respectively
