10513-96-9

Basic information

• Product Name: 1H-Isoindole-1,3(2H)-dione,2,2'-(1,3-propanediyl)bis-
• Synonyms: Phthalimide,N,N'-trimethylenedi- (6CI,7CI,8CI); NSC 64651; NSC 64844
• CAS NO: 10513-96-9
• Molecular Formula: C19H14 N2 O4
• Molecular Weight: 334.331
• Mol File: 10513-96-9.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 523.9°Cat760mmHg
• Flash Point: 244.8°C
• Density: 1.421g/cm³
• CAS DataBase Reference: 1H-Isoindole-1,3(2H)-dione,2,2'-(1,3-propanediyl)bis-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Isoindole-1,3(2H)-dione,2,2'-(1,3-propanediyl)bis-(10513-96-9)
• EPA Substance Registry System: 1H-Isoindole-1,3(2H)-dione,2,2'-(1,3-propanediyl)bis-(10513-96-9)

Safety Data

• Hazardous Substances Data: 10513-96-9(Hazardous Substances Data)

Usage

Chemical Family

Isoindole

Derivative

Phthalimide

Uses

Production of dyes, pigments, and pharmaceuticals

Physical Form

White to off-white crystalline powder

Solubility

Insoluble in water, soluble in organic solvents

Safety Precautions

Potential health hazards and environmental impact, handle with care and in accordance with safety protocols.

Upstream product

• 85-44-9 phthalic anhydride 
• 109-76-2 Trimethylenediamine 
• 5457-29-4 N-(3-iodopropyl)phthalimide 
• 82333-41-3 8-amino-6-methoxy-4-methyl-5-(3-trifluoromethylphenoxy)quinoline 

Downstream Products

• 68388-03-4 N,N'-(propane-1,3-diyl)dibenzamide 
• 121821-32-7 4,9,13,18-tetratosyl-N¹,N¹:N²¹,N²¹-diphthaloyl-4,9,13,18-tetraazaheneicosane-1,21-diamine 
• 121821-31-6 N,N'-bis(3-phthalimidopropyl)-N,N'-ditosyl-1,3-propanediamine 
• 121821-26-9 4,8,13,17-tetratosyl-N¹,N¹:N²⁰,N²⁰-diphthaloyl-4,8,13,17-tetraazaeicosane-1,20-diamine 
• 107976-61-4 N,N'-bis(3-phthalimidopropyl)-N,N'-ditosyl-1,4-butanediamine 
• 88597-05-1 N-<3-(N-nitroso-p-tolylsulfonamido)propyl>phthalimide 
• 88597-06-2 3-(phthalimido)propyl-p-toluenesulfonate 
• 121821-01-0 2-(3-aminopropyl)isoindoline-1,3-dione hydrochloride 
• 38353-77-4 N-(N³-p-toluenesulfonyl)-3-aminopropylphthalimide 

Relevant articles and documents

Unmasking Amides: Ruthenium-Catalyzed Protodecarbonylation of N-Substituted Phthalimide Derivatives

The unprecedented transformation of a wide range of synthetically appealing phthalimides into amides in a single-step operation has been achieved in high yields and short reaction times using a ruthenium catalyst. Mechanistic studies revealed a unique, homogeneous pathway involving five-membered ring opening and CO2 release with water being the source of protons.

Thalidomide analogs from diamines: Synthesis and evaluation as inhibitors of TNF-α production

Fourteen thalidomide analogs bearing two phthalimido units were prepared in high yields (83-94%) by condensation of different diamines with phthalic or 3-nitrophthalic anhydride. An in vitro investigation of the compounds as inhibitors of the TNF-α production was performed. The inhibition was higher for compounds bearing amino and nitro groups and was modulated by increasing the size of the spacers between the phthalimide groups.