1051970-96-7Relevant articles and documents
Process for the resolution of homocysteine-thiolactone
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Page/Page column 5, (2008/12/08)
The present invention relates to a process for the preparation of enantiomerically pure homocysteine-γ-thiolactone comprising optical resolution of racemic homocysteine-γ-thiolactone (I) with a chiral organic acid wherein one isomer is recovered as diastereomeric salt with the organic acid and the other isomer remaining in the mother liquor is submitted to racemisation with a catalytic amount of an aromatic aldehyde and submitted again to optical resolution with the same chiral organic acid.