1053188-07-0

Basic information

• Product Name: 2-bromo-N-(2-iodophenyl)-N-methylbenzamide
• Synonyms: 2-bromo-N-(2-iodophenyl)-N-methylbenzamide
• CAS NO: 1053188-07-0
• Molecular Weight: 416.056
• Mol File: 1053188-07-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-bromo-N-(2-iodophenyl)-N-methylbenzamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-bromo-N-(2-iodophenyl)-N-methylbenzamide(1053188-07-0)
• EPA Substance Registry System: 2-bromo-N-(2-iodophenyl)-N-methylbenzamide(1053188-07-0)

Safety Data

• Hazardous Substances Data: 1053188-07-0(Hazardous Substances Data)

Upstream product

• 202132-25-0 2-bromo-N-(2-iodophenyl)benzamide 
• 74-88-4 methyl iodide 
• 7154-66-7 2-bromobenzoic acid chloride 
• 615-43-0 2-iodophenylamine 
• 57056-93-6 N-methyl-2-iodoaniline 

Relevant articles and documents

Dibenzo[ b, e ]azepin-6-ones and Seven-Membered Sultam Derivatives: Convenient Synthesis via Palladium-Catalyzed Regioselective Intramolecular Heck Reaction and Application towards Drug-Like Small Molecules

A new, convenient synthesis of dibenzo[ b, e ]azepin-6-ones and seven-membered sultam derivatives have been envisaged via Pd-catalyzed regioselective intramolecular Heck reaction of the corresponding easily accessible precursors. This protocol has been successfully implemented to synthesize N -methyldarenzepine in four steps and in good yield. Moreover, one of the intermediates has been utilized for the synthesis of a new analogue of darenzepine. Preliminary modeling studies were performed to investigate the binding potential to muscarinic acetylcholine receptor (M4).

Samarium(II)-mediated spirocyclization by intramolecular aryl radical addition onto an aromatic ring

(Chemical Equation Presented) Samarium(II)-mediated spirocyclization by intramolecular addition of aryl radicals onto an aromatic ring was achieved by the reaction of N-(2-iodophenyl)-N-alkylbenzamides with SmI2 in the presence of HMPA, yielding spirocyclic indolin-2-one derivatives. The ether congeners afford spirocyclic benzofuran derivatives in moderate yields by aryl radical addition onto a benzene ring without having an electron-withdrawing group. The reaction with other aryl groups such as naphthalene and indole rings is also described.