105589-77-3

Basic information

• Product Name: Tr-PEG3
• Synonyms: Tr-PEG3;2-(2-(trityloxy)ethoxy)ethanol;2-(2-(trityloxy)ethoxy)ethanol(WXPC0042)
• CAS NO: 105589-77-3
• Molecular Formula: C₂₃H₂₄O₃
• Molecular Weight: 348.43486
• Mol File: 105589-77-3.mol

Chemical Properties

• Boiling Point: 481.9±40.0 °C(Predicted)
• Appearance: /
• Density: 1.127±0.06 g/cm3(Predicted)
• PKA: 14.35±0.10(Predicted)
• CAS DataBase Reference: Tr-PEG3(CAS DataBase Reference)
• NIST Chemistry Reference: Tr-PEG3(105589-77-3)
• EPA Substance Registry System: Tr-PEG3(105589-77-3)

Safety Data

• Hazardous Substances Data: 105589-77-3(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Tr-PEG3 is used as a solubility enhancer for increasing the water solubility of hydrophobic drugs, which can improve their bioavailability and pharmacokinetic properties. The hydrophilic PEG linker aids in the dispersion of the drug in aqueous environments, facilitating better absorption and distribution within the body.
Used in Drug Delivery Systems:
Tr-PEG3 is used as a component in the design of drug delivery systems, such as nanoparticles, liposomes, and hydrogels. The PEG chain can provide stealth properties, reducing the recognition and clearance of the delivery system by the immune system, thereby extending the circulation time and enhancing the therapeutic efficacy of the encapsulated drug.
Used in Bioconjugation and Labeling:
Tr-PEG3 is used as a spacer or linker in bioconjugation and labeling applications, such as attaching targeting ligands, fluorescent tags, or other functional groups to biomolecules like proteins, peptides, or nucleic acids. The PEG chain can improve the stability, solubility, and biocompatibility of the resulting conjugates, while the trityl ether protection group allows for selective and controlled conjugation under mild conditions.
Used in Polymer Science and Materials:
Tr-PEG3 can be utilized as a building block or additive in the synthesis of various polymers and materials, such as hydrogels, block copolymers, and surface coatings. The PEG chain can impart properties like enhanced water solubility, improved biocompatibility, and reduced protein adsorption, making these materials suitable for a range of applications, including tissue engineering, diagnostics, and sensors.

Upstream product

• 76-83-5 trityl chloride 
• 111-46-6 diethylene glycol 
• 76-84-6 triphenylmethyl alcohol 
• 596-43-0 bromo-triphenyl-methane 

Downstream Products

• 144270-98-4 1,1,1,27,27,27-hexaphenyl-2,5,8,11,14,17, 20,23,26-nonaoxaheptacosane 
• 146462-58-0 2-<2-(triphenylmethoxy)ethoxy>ethyl methanesulfonate 
• 141282-25-9 2-[2-(triphenylmethoxy)ethoxy]ethyl 4-methylbenzene-1-sulfonate 
• 153010-95-8 1-methoxy-5-trityloxy-3-oxapentane 
• 844696-51-1 2-[2-(2-trityloxyethoxy)ethoxymethyl]oxirane 
• 915225-35-3 C₅₈H₅₆N₂O₆ 
• 844696-52-2 1,3-bis[2-(2-trityloxyethoxy)ethoxy]propan-2-ol 
• 1206723-96-7 C₅₅H₅₂O₈ 
• 1206723-94-5 C₃₄H₃₅NO₆ 
• 125274-16-0 1,1,1-triphenyl-2,5,8,11-tetraoxatridecan-13-ol 
• 146462-60-4 2-(2-(2-<2-(triphenylmethoxy)ethoxy>ethoxy)ethoxy)ethyl methanesulfonate 
• 868594-38-1 1-azido-11-(triphenylmethyloxy)-3,6,9-undecane 
• 1144113-16-5 2-(2-{2-[2-(2-{2-[2-(2-trityloxyethoxy)ethoxy]ethoxy}ethoxy)ethoxy]ethoxy}ethoxy)ethanol 
• 745048-16-2 19,19,19-triphenyl-3,6,9,12,15,18-hexaoxanonadec-1-ylmethanesulfonate 

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