105589-77-3

Basic information

• Product Name: Tr-PEG3
• Synonyms: Tr-PEG3;2-(2-(trityloxy)ethoxy)ethanol;2-(2-(trityloxy)ethoxy)ethanol(WXPC0042)
• CAS NO: 105589-77-3
• Molecular Formula: C₂₃H₂₄O₃
• Molecular Weight: 348.43486
• Mol File: 105589-77-3.mol
• Article Data: 22

Chemical Properties

• Boiling Point: 481.9±40.0 °C(Predicted)
• Appearance: /
• Density: 1.127±0.06 g/cm3(Predicted)
• PKA: 14.35±0.10(Predicted)
• CAS DataBase Reference: Tr-PEG3(CAS DataBase Reference)
• NIST Chemistry Reference: Tr-PEG3(105589-77-3)
• EPA Substance Registry System: Tr-PEG3(105589-77-3)

Safety Data

• Hazardous Substances Data: 105589-77-3(Hazardous Substances Data)

Usage

Description

Tr-PEG3 is a trityl ether protected PEG chain. The trityl ether can be removed under mildly acidic conditions or via hydrogenolysis. The hydrophilic PEG linker increases the water solubility of the compound in aqueous media.

Upstream product

• 76-84-6 triphenylmethyl alcohol 
• 111-46-6 diethylene glycol 
• 596-43-0 bromo-triphenyl-methane 
• 76-83-5 trityl chloride 

Downstream Products

• 144270-98-4 1,1,1,27,27,27-hexaphenyl-2,5,8,11,14,17, 20,23,26-nonaoxaheptacosane 
• 844696-51-1 2-[2-(2-trityloxyethoxy)ethoxymethyl]oxirane 
• 1453169-17-9 C₂₄H₂₄O₃ 
• 879555-56-3 C₅₁H₅₅N₃O₇ 
• 877239-08-2 1-azide-31,31,31-triphenyl-3,6,9,12,15,18,21,24,27,30-decaoxahentriacontanol 
• 125274-14-8 2-{2-[2-(2-{2-[2-(2-{2-[2-(2-trityloxy-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-ethoxy}-ethanol 
• 1444123-36-7 C₃₁H₃₉N₃O₆ 
• 745048-16-2 19,19,19-triphenyl-3,6,9,12,15,18-hexaoxanonadec-1-ylmethanesulfonate 

Relevant articles and documents

Synthesis of gemini surfactants with twelve symmetric fluorine atoms and one singlet 19F MR signal as novel 19F MRI agents

A family of fluorinated gemini surfactants derived from perfluoropinacol has been synthesized as novel 19F magnetic resonance imaging ( 19F MRI) agents. These fluorinated surfactants with 12 symmetric fluorine atoms and one singlet

An ion conductor that recognizes osmotically-stressed phospholipid bilayers

A synthetic ion conductor (1), derived from cholic acid and spermine, has been found capable of recognizing osmotic stress in liposomes made from 1,2-dipalmitoleoyl-sn-glycero-3-phosphocholine [(C16:1)PC]. Thus, when large unilamellar vesicles of (C16:1)PC are placed under hypotonic conditions, the Na+/Li+ transport activity of 1 increases by as much as 1 order of magnitude, relative to isotonic conditions Copyright

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A Highly Selective Synthesis of Monodisperse Oligo(ethylene glycols)

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Ligand-Phospholipid Conjugation: A Versatile Strategy for Developing Long-Acting Ligands That Bind to Membrane Proteins by Restricting the Subcellular Localization of the Ligand

We hypothesized that if drug localization can be restricted to a particular subcellular domain where their target proteins reside, the drugs could bind to their target proteins without being metabolized and/or excreted, which would significantly extend the half-life of the corresponding drug-target complex. Thus, we designed ligand-phospholipid conjugates in which the ligand is conjugated with a phospholipid through a polyethylene glycol linker to restrict the subcellular localization of the ligand in the vicinity of the lipid bilayer. Here, we present the design, synthesis, pharmacological activity, and binding mode analysis of ligand-phospholipid conjugates with muscarinic acetylcholine receptors as the target proteins. These results demonstrate that ligand-phospholipid conjugation can be a versatile strategy for developing long-acting ligands that bind to membrane proteins in drug discovery.

Highly efficient synthesis of monodisperse poly(ethylene glycols) and derivatives through macrocyclization of oligo(ethylene glycols)

A macrocyclic sulfate (MCS)-based approach to monodisperse poly(ethylene glycols) (M-PEGs) and their monofunctionalized derivatives has been developed. Macrocyclization of oligo(ethylene glycols) (OEGs) provides MCS (up to a 62-membered macrocycle) as versatile precursors for a range of monofunctionalized M-PEGs. Through iterative nucleophilic ring-opening reactions of MCS without performing group protection and activation, a series of M-PEGs, including the unprecedented 64-mer (2850Da), can be readily prepared. Synthetic simplicity coupled with versatility of this new strategy may pave the way for broader applications of M-PEGs. Macrocycles make synthesis easier: Convenient macrocyclization of the OEGs provides versatile macrocyclic sulfates. These compounds are cornerstones for both monofunctionalization of OEGs and highly efficient synthesis of monodisperse PEGs and derivatives, including an unprecedented 64-mer.