1056904-42-7Relevant articles and documents
Reaction-based indicator displacement assay (RIA) for the development of a triggered release system capable of biofilm inhibition
Patenall, Bethany L.,Williams?, George T.,Gwynne, Lauren,Stephens, Liam J.,Lampard, Emma V.,Hathaway, Hollie J.,Thet, Naing T.,Young, Amber E.,Sutton, Mark J.,Short, Robert D.,Bull, Steven D.,James, Tony D.,Sedgwick, Adam C.,Jenkins, A. Toby A.
, p. 15129 - 15132 (2019)
Here, a reaction-based indicator displacement hydrogel assay (RIA) was developed for the detection of hydrogen peroxide (H2O2) via the oxidative release of the optical reporter Alizarin Red S (ARS). In the presence of H2O2, the RIA system displayed potent biofilm inhibition for Methicillin-resistant Staphylococcus aureus (MRSA), as shown through an in vitro assay quantifying antimicrobial efficacy. This work demonstrated the potential of H2O2-responsive hydrogels containing a covalently bound diol-based drug for controlled drug release.