1057393-50-6

Basic information

• Product Name: 7-iodo-3-(1-methylcyclopropyl)-[1,2,4]triazolo[4,3-a]pyridine
• CAS NO: 1057393-50-6
• Molecular Weight: 299.114
• Mol File: 1057393-50-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 7-iodo-3-(1-methylcyclopropyl)-[1,2,4]triazolo[4,3-a]pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 7-iodo-3-(1-methylcyclopropyl)-[1,2,4]triazolo[4,3-a]pyridine(1057393-50-6)
• EPA Substance Registry System: 7-iodo-3-(1-methylcyclopropyl)-[1,2,4]triazolo[4,3-a]pyridine(1057393-50-6)

Safety Data

• Hazardous Substances Data: 1057393-50-6(Hazardous Substances Data)

Upstream product

• 22282-70-8 2-fluoro-4-iodopyridine 
• 16480-05-0 1-methylcyclopropanecarbonyl chloride 
• 6914-76-7 1-Methyl-cyclopropanoic acid 
• 1375801-56-1 C₁₀H₁₂IN₃O 
• 1057393-44-8 2-hydrazinyl-4-iodopyridine 

Downstream Products

• 1057393-97-1 N-cyclopropyl-4-methyl-3-(3-(1-methylcyclopropyl)-[1,2,4]triazolo[4,3-a]pyridin-7-yl)benzamide 
• 1057394-31-6 N-cyclopropyl-3-fluoro-4-methyl-5-[3-(1-methylcyclopropyl)[1,2,4]triazolo[4,3-a]pyridin-7-yl]benzamid 

Relevant articles and documents

Novel triazolopyridylbenzamides as potent and selective p38α inhibitors

A new class of p38α inhibitors based on a biaryl-triazolopyridine scaffold was investigated. X-ray crystallographic data of the initial lead compound cocrystallised with p38α was crucial in order to uncover a unique binding mode of the inhibitor to the hinge region via a pair of water molecules. Synthesis and SAR was directed towards the improvement of binding affinity, as well as ADME properties for this new class of p38α inhibitors and ultimately afforded compounds showing good in vivo efficacy.