1057678-43-9

Usage

Type of compound

Haloalkyl benzene derivative

Structure

Contains a bromine atom and two fluorine atoms attached to a central benzene ring

Functional groups

Bromine atom, fluorine atoms, and benzene ring

Uses

Intermediate in organic synthesis, production of pharmaceuticals, agrochemicals, and specialty chemicals

Application

Research and development for unique chemical properties and reactivity

Safety precautions

Proper handling and storage due to potentially hazardous nature

Upstream product

• 957204-67-0 3-(2,4-difluorophenyl)propan-1-ol 
• 23915-07-3 1-(bromomethyl)-2,4-difluorobenzene 
• 134672-70-1 3-(2,4-difluorophenyl)-propionic acid 

Downstream Products

• 1093173-22-8 [5-(2-{4-[3-(2,4-difluorophenyl)propoxy]-3-trifluoromethylphenyl}ethyl)-2,2-dimethyl-1,3-dioxan-5-yl]carbamic acid t-butyl ester 
• 156868-39-2 1-(1,3-Difluoro-5,6,7,8-tetrahydro-5,5-dimethyl-2-naphthalenyl)ethanone 

Relevant academic research and scientific papers

Air-Stable PdI Dimer Enabled Remote Functionalization: Access to Fluorinated 1,1-Diaryl Alkanes with Unprecedented Speed

While remote functionalization via chain walking has the potential to enable access to molecules via novel disconnections, such processes require relatively long reaction times and can be in need of elevated temperatures. This work features a remote arylation in less than 10 min reaction time at room temperature over a distance of up to 11 carbons. The unprecedented speed is enabled by the air-stable PdI dimer [Pd(μ-I)(PCy2tBu)]2, which in contrast to its PtBu3 counterpart does not trigger direct coupling at the initiation site, but regioconvergent and chemoselective remote functionalization to yield valuable fluorinated 1,1-diaryl alkanes. Our combined experimental and computational studies rationalize the origins of switchability, which are primarily due to differences in dispersion interactions.

AMINE COMPOUND AND PHARMACEUTICAL USE THEREOF

Provided is a novel amine compound represented by the following formula (I) having a superior peripheral blood lymphocyte decreasing action and superior in the immunosuppressive action, rejection suppressive action and the like, which shows decreased side effects of, for example, bradycardia and the like, or a pharmaceutically acceptable acid addition salt thereof, or a hydrate thereof, or a solvate thereof. wherein each symbol is as defined in the specification.

Syntheses of Tetrahydronaphthalenes. Part II

Syntheses utilizing the cyclodehydration method to prepare novel tetrahydronaphthalenes substituted with functional groups at each position of the aromatic ring and various alkyl groups at the 1-position of the non-aromatic ring are described.