957204-67-0

Basic information

• Product Name: 3-(2,4-DIFLUORO-PHENYL)-PROPAN-1-OL
• Synonyms: 3-(2,4-DIFLUORO-PHENYL)-PROPAN-1-OL
• CAS NO: 957204-67-0
• Molecular Formula: C₉H₁₀F₂O
• Molecular Weight: 172.1719064
• Mol File: 957204-67-0.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-(2,4-DIFLUORO-PHENYL)-PROPAN-1-OL(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(2,4-DIFLUORO-PHENYL)-PROPAN-1-OL(957204-67-0)
• EPA Substance Registry System: 3-(2,4-DIFLUORO-PHENYL)-PROPAN-1-OL(957204-67-0)

Safety Data

• Hazardous Substances Data: 957204-67-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Synthesis:
3-(2,4-DIFLUORO-PHENYL)-PROPAN-1-OL is used as a key intermediate in the synthesis of pharmaceuticals for its ability to contribute to the development of new and potentially beneficial molecules.
Used in Organic Compounds Synthesis:
In the field of organic chemistry, 3-(2,4-DIFLUORO-PHENYL)-PROPAN-1-OL is utilized as a precursor for the production of various organic compounds, highlighting its versatility and importance in chemical research and development.
Used in Medicinal Chemistry and Drug Discovery:
3-(2,4-DIFLUORO-PHENYL)-PROPAN-1-OL is employed as a valuable building block in medicinal chemistry and drug discovery, where its unique structure aids in the creation of innovative therapeutic agents.
It is crucial to handle 3-(2,4-DIFLUORO-PHENYL)-PROPAN-1-OL with care due to its potential harmful effects if ingested or inhaled, and its ability to cause skin and eye irritation.

Upstream product

• 75-21-8 oxirane 
• 23915-07-3 1-(bromomethyl)-2,4-difluorobenzene 
• 134672-70-1 3-(2,4-difluorophenyl)-propionic acid 
• 288100-99-2 3-(2,4-difluorophenyl)-2-propyn-1-ol 

Downstream Products

• 957204-68-1 3-(2,4-Difluorophenyl)-1-methanesulfonyloxypropane 
• 1057670-89-9 C₉H₈F₂O 
• 156868-39-2 1-(1,3-Difluoro-5,6,7,8-tetrahydro-5,5-dimethyl-2-naphthalenyl)ethanone 
• 1057678-43-9 1-(3-bromopropyl)-2,4-difluorobenzene 

Relevant articles and documents

Air-Stable PdI Dimer Enabled Remote Functionalization: Access to Fluorinated 1,1-Diaryl Alkanes with Unprecedented Speed

While remote functionalization via chain walking has the potential to enable access to molecules via novel disconnections, such processes require relatively long reaction times and can be in need of elevated temperatures. This work features a remote arylation in less than 10 min reaction time at room temperature over a distance of up to 11 carbons. The unprecedented speed is enabled by the air-stable PdI dimer [Pd(μ-I)(PCy2tBu)]2, which in contrast to its PtBu3 counterpart does not trigger direct coupling at the initiation site, but regioconvergent and chemoselective remote functionalization to yield valuable fluorinated 1,1-diaryl alkanes. Our combined experimental and computational studies rationalize the origins of switchability, which are primarily due to differences in dispersion interactions.

Synthesis and inhibitory studies of phosphonic acid analogues of homophenylalanine and phenylalanine towards alanyl aminopeptidases

A library of novel phosphonic acid analogues of homophenylalanine and phenylalanine, containing fluorine and bromine atoms in the phenyl ring, have been synthesized. Their inhibitory properties against two important alanine aminopeptidases, of human (hAPN, CD13) and porcine (pAPN) origin, were evaluated. Enzymatic studies and comparison with literature data indicated the higher inhibitory potential of the homophenylalanine over phenylalanine derivatives towards both enzymes. Their inhibition constants were in the submicromolar range for hAPN and the micromolar range for pAPN, with 1-amino-3-(3-fluorophenyl) propylphosphonic acid (compound 15c) being one of the best low-molecular inhibitors of both enzymes. To the best of our knowledge, P1 homophenylalanine analogues are the most active inhibitors of the APN among phosphonic and phosphinic derivatives described in the literature. Therefore, they constitute interesting building blocks for the further design of chemically more complex inhibitors. Based on molecular modeling simulations and SAR (structure-activity relationship) analysis, the optimal architecture of enzyme-inhibitor complexes for hAPN and pAPN were determined.

2-AMINO-1,3,4-THIADIAZINE AND 2-AMINO-1,3,4-OXADIAZINE BASED ANTIFUNGAL AGENTS

The invention provides a compound which is a diazine of formula (I) or a tautomer thereof, or a pharmaceutically acceptable salt thereof, for use as an antifungal agent: (I) wherein X, N', C', A and E are as defined herein. The invention also provides a compound of Formula (I) as defined herein.

AMINE COMPOUND AND PHARMACEUTICAL USE THEREOF

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HETEROARYLAMIDE LOWER CARBOXYLIC ACID DERIVATIVE

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